1. Home
  2. Research
  3. Research Groups
  4. Biology and Evolution of Microorganisms

Biology and Evolution of Microorganisms

The Biology and Evolution of Microorganisms Group, whose head is Dr. Rafael Cantón and which is made up of nine other principal investigators as well as numerous pre- and post-doctoral researchers, technicians and other healthcare personnel, has participated in the last 5 years in 17 national and international research projects and in 15 contracts with pharmaceutical companies or companies dedicated to in vitro diagnostics. During this period of time this work has resulted in more than 190 publications in national and international journals with a high impact index and more than 11 doctoral theses. Likewise, more than 400 communications have been presented at numerous national and international congresses. And all this always seeking the highest excellence in the fields of population biology, antibiotic resistance, respiratory infection, microbiota, metagenomics and HIV.

Search for publications

Only original articles, editorials, guidelines.

  • Torumkuney D, Canton R, Pitart C, Sanguinetti M, Vismara C, Farina C, Sambri V, Hawser S, Manoharan A.

    Results from the Survey of Antibiotic Resistance (SOAR) 2018-21 in Italy and Spain: data based on CLSI, EUCAST (dose-specific) and pharmacokinetic/pharmacodynamic (PK/PD) breakpoints

    JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY . 80: 2-18.

    [doi:10.1093/jac/dkaf283]

  • Pérez-Molina JA, Moreno E, Crespillo-Andújar C, Chamorro-Tojeiro S, Arsuaga M, Olavarrieta L, Martín O, Monge-Maillo B, Norman F, Lanza VF, Serrano-Villar S.

    Chagas disease induces gut microbial metabolic stress: Disruption of energy and nucleotide pathways and partial reversal by antiparasitic therapy (TRIPOBIOME-2 study)

    TRAVEL MEDICINE AND INFECTIOUS DISEASE . 67: 102881-102881.

    [doi:10.1016/j.tmaid.2025.102881]

  • Boattini M, Aceti A, Bastos P, Mavromanolaki VE, Maraki S, Spiliopoulou A, Kakouris V, Kalchev Y, Budimir A, Bedenic B, Rubic Z, Licker M, Musuroi C, Juhász E, Kristóf K, Pirs M, Velimirovic I, Berktold M, Liptáková A, Krajcíková A, Drevinek P, Gryndlerova A, Brzychczy-Wloch M, Olechowska-Jarzab A, Bielec F, Brauncajs M, Podsiadly E, Nurzynska G, Zalas-Wiecek P, Michalska A, Riesbeck K, Andersson HS, Tønjum T, Berild JC, Leegaard TM, Rasmussen AN, Schønning K, Glöckner S, Rödel J, Badr MT, Häcker GA, Stark D, Hamprecht A, Dudakova A, Jantsch J, Mancini S, Quiblier C, Jacot D, Greub G, Ferniani T, Ambretti S, Calvo M, Stefani S, Schade R, Yusuf E, van Kleef-van Koeveringe S, Vandamme S, Verroken A, Rodriguez-Villalobos H, Duigou F, Corvec S, Floch P, Massip C, Chainier D, Barraud O, Louissaint MB, Mizrahi A, Ali S, Doyle M, Egan C, McNicholas S, Colomina-Rodriguez J, Torres I, Gillaranz Luengo R, Larrosa Escartín MN, Viñado Perez MB, Halperin AV, Fuente García S, Cantón R, Seruca M, Santos Mendes V, Carvalho D, Cavallo R, Melo Cristino J, Costa C, Bianco G.

    A European survey on anaerobes from paediatric blood cultures: a comparative analysis with adults

    EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES . 44(9): 2207-2217.

    [doi:10.1007/s10096-025-05185-7]

  • Alonso S, Salazar E, Gálvez N, Navas J, Quintana C, Orózco N, Prieto L, Navarro ML, Guillén S, Gómez-Alba JM, Medina-Sánchez C, Juarez J, Holguín A.

    Prevalence of acquired resistance to antiretrovirals in children and adolescents living with HIV under clinical follow-up at the Roosevelt Hospital in Guatemala

    Journal of Infection and Public Health . 18(9): 102827-102827. Number of citations: 1

    [doi:10.1016/j.jiph.2025.102827]

  • Cercenado E, Alcalá L, Irigoyen-von-Sierakowski Á, Rodríguez-Sánchez B, Marín M.

    Activity of imipenem-relebactam, ceftolozane-tazobactam and comparators against clinical isolates of Enterobacterales and Pseudomonas aeruginosa causing severe infections in hematological and oncological patients: A prospective multicenter study.

    INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS . 66(3): 107534-107534.

    [doi:10.1016/j.ijantimicag.2025.107534]

  • Sanmartín Á, Iturbe P, Rodríguez-Beltrán J, Lasa I.

    ExcludonFinder: mapping transcriptional overlaps between neighboring genes

    NUCLEIC ACIDS RESEARCH . 53(14): .

    [doi:10.1093/nar/gkaf686]

  • Hernández-García M, Nieto-Torres M, Guerra-Pinto N, Castillo-Polo JA, Saez de la Fuente J, Michelena M, Ponce-Alonso M, Soriano-Cuesta C, Díaz-Agero C, Cantón R, Coque TM, Ruiz-Garbajosa P.

    ICU environment as a reservoir of KPC-ST307-Klebsiella pneumoniae high-risk clone resistant to ceftazidime-avibactam

    SCIENTIFIC REPORTS . 15(1): 29486-29486.

    [doi:10.1038/s41598-025-14987-w]

  • Avendaño-Ortiz J, Aguilera-Alonso D, Rodríguez CM, Oteo-Iglesias J, Lozano-Rodríguez R, López-Collazo E, López-Suárez A, Rello-Saltor V, Jimenez AB, Jiménez B, del Campo R, Cantón R, Calvo C, Saavedra-Lozano J.

    Plasma calprotectin as a severity biomarker in pediatric invasive Streptococcus pyogenes infections: insights from a multicenter immune profiling study during an outbreak.

    Journal of microbiology, immunology, and infection = Wei mian yu gan ran za zhi . : .

    [doi:10.1016/j.jmii.2025.07.008]

  • Gupta K, Wagenlehner F, Wilcox M, Advani SD, Bilsen M, Bonkat G, Cantón R, Geerlings S, Grabein B, Horcajada JP, Kushner P, Narayanan N, Scheetz M.

    Urinary tract infection in adults: gaps in current guidelines - opinions from an international multidisciplinary panel and relevance to clinical practice.

    BMC Proceedings . 19(Suppl 16): 18-18. Number of citations: 2

    [doi:10.1186/s12919-025-00333-5]

  • Serrano-Tomás MI, Contreras-Romero P, Parellada M, Chaves-Cordero J, Zamora J, Hengst M, Pozo P, del Campo R, Guzmán-Salas S.

    Recognition of the microbial metabolite p-cresol in autism spectrum disorder: systematic review and meta-analysis

    FRONTIERS IN MOLECULAR NEUROSCIENCE . 18: 1576388-1576388. Number of citations: 2

    [doi:10.3389/fnmol.2025.1576388]

  • Ramiro-Martínez P, de Quinto I, Lanza VF, Gama JA, Rodríguez-Beltrán J.

    Universal rules govern plasmid copy number.

    NATURE COMMUNICATIONS . 16(1): 6022-6022. Number of citations: 4

    [doi:10.1038/s41467-025-61202-5]

  • Reinosa R, Troyano-Hernáez P, Valadés-Alcaraz A, Holguín Á.

    EpiMolBio: A novel user-friendly bioinformatic program for genetic variability analysis

    Computational and Structural Biotechnology Journal . 27: 2968-2975.

    [doi:10.1016/j.csbj.2025.06.034]

  • Rodríguez-Goncer I, Ruiz-Arabi E, Herrera S, Sabé N, Los-Arcos I, Silva JT, Pérez-Nadales E, Machuca I, Álvarez R, Valerio M, Castón JJ, Aguilera V, Bodro M, Cano Á, Cantón R, Carmona P, Carratalà J, Cordero E, Cruzado JM, Fariñas MC, Fernández-Ruiz M, Fondevila C, Fortún J, García-Cosío MD, Gutiérrez-Dalmau A, Iturbe D, Justo I, Len O, López-Medrano F, López Oliva MO, Martín-Dávila P, Martínez-Martínez L, Mazuecos A, Mirabet S, Muñoz P, Oliver A, Pérez-Sáez MJ, Rodríguez-Gómez J, San-Juan R, Sánchez-Céspedes J, Solé A, Vidal Verdú E, Villa J, Torre-Cisneros J, Aguado JM.

    Management of multidrug-resistant gram-negative bacilli infections in adult solid organ transplant recipients: GESITRA-IC/SEIMC, CIBERINFEC, and SET recommendations update.

    TRANSPLANTATION REVIEWS . 39(3): 100937-100937. Number of citations: 2

    [doi:10.1016/j.trre.2025.100937]

  • Baquero F, Cantón R, Pérez-Cobas AE, Coque TM, Levin B, Rodríguez-Beltrán J.

    Antechodynamics and Antechokinetics: Dynamics and Kinetics of Antibiotic Resistance Biomolecules

    Biomolecules . 15(6): . Number of citations: 2

    [doi:10.3390/biom15060823]

  • Boattini M, Bianco G, Bastos P, Mavromanolaki VE, Maraki S, Spiliopoulou A, Kakouris V, Kalchev Y, Budimir A, Bedenic B, Rubic Z, Licker M, Musuroi C, Juhász E, Kristóf K, Pirs M, Velimirovic I, Berktold M, Liptáková A, Krajcikova A, Drevinek P, Gryndlerova A, Brzychczy-Wloch M, Olechowska-Jarzab A, Bielec F, Brauncajs M, Podsiadly E, Nurzynska G, Zalas-Wiecek P, Riesbeck K, Andersson HS, Tønjum T, Berild JC, Leegaard TM, Rasmussen AN, Schønning K, Glöckner S, Rödel J, Badr MT, Häcker GA, Stark D, Hamprecht A, Dudakova A, Jantsch J, Mancini S, Quiblier C, Jacot D, Greub G, Ferniani T, Ambretti S, Calvo M, Stefani S, Schade R, Yusuf E, Koeveringe SVK, Vandamme S, Verroken A, Rodriguez-Villalobos H, Duigou F, Corvec S, Floch P, Massip C, Chainier D, Barraud O, Louissaint MB, Mizrahi A, Ali S, Doyle M, Egan C, McNicholas S, Colomina-Rodriguez J, Torres I, Luengo RG, Escartín MNL, Perez MBV, Halperin AV, García SF, Cantón R, Seruca M, Mendes VS, Carvalho D, Cavallo R, Cristino JM, Costa C.

    Diagnostic and epidemiological landscape of anaerobic bacteria in Europe, 2020-2023 (ANAEuROBE)

    INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS . 65(6): 107478-107478. Number of citations: 3

    [doi:10.1016/j.ijantimicag.2025.107478]

  • Ortiz-Miravalles L, Prieto A, Kieffer N, Vergara E, Cantón R, San Millán Á, Baquero F, Hipólito A, Escudero JA.

    Effect of oxygen on antimicrobial resistance genes from a one health perspective.

    The Science of the total environment . 979: 179523-179523. Number of citations: 1

    [doi:10.1016/j.scitotenv.2025.179523]

  • Maruri-Aransolo A, Quintana E, Michelena-González M, Pastor-Vivero MD, Álvarez A, Girón R, Alarcón T, Luna-Paredes C, Máiz L, Vicente S, de Valbuena MR, Prados MC, Castillo-Corullón S, Selma MJ, Solé A, Cols-Roig M, Mondéjar-López P, Ruiz EP, Olveira C, Aguilera PC, Ruiz PB, Causapé CL, Figuerola J, Asensio O, Caballero-Pérez JD, Cantón R.

    Bronchopulmonary colonization patterns in Spanish people with cystic fibrosis: Results of a national multicentre study.

    Enfermedades Infecciosas Y Microbiologia Clinica (english Ed.) . 43(6): 309-316.

    [doi:10.1016/j.eimce.2024.08.008]

  • Gayoso-Cantero D, Corbacho-Loarte MD, Crespillo-Andújar C, Chamorro-Tojeiro S, Norman F, Perez-Molina JA, González-Sanz M, Martín O, Rubio JM, Gullón-Peña B, Del Campo Albendea L, López-Vélez R, Monge-Maillo B.

    Changes in Lipid Profile Secondary to Asymptomatic Malaria in Migrants from Sub-Saharan Africa: A Retrospective Analysis of a 2010-2022 Cohort

    Tropical Medicine and Infectious Disease . 10(5): . Number of citations: 2

    [doi:10.3390/tropicalmed10050134]