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Biology and Evolution of Microorganisms

The Biology and Evolution of Microorganisms Group, whose head is Dr. Rafael Cantón and which is made up of nine other principal investigators as well as numerous pre- and post-doctoral researchers, technicians and other healthcare personnel, has participated in the last 5 years in 17 national and international research projects and in 15 contracts with pharmaceutical companies or companies dedicated to in vitro diagnostics. During this period of time this work has resulted in more than 190 publications in national and international journals with a high impact index and more than 11 doctoral theses. Likewise, more than 400 communications have been presented at numerous national and international congresses. And all this always seeking the highest excellence in the fields of population biology, antibiotic resistance, respiratory infection, microbiota, metagenomics and HIV.

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Only original articles, editorials, guidelines.

  • Halperin AV, Schwartz F, Christophersen L, Pérez-Del Palacio J, Ponce-Alonso M, Avendaño-Ortiz J, Caballero JD, Cantón R, Moser C, Del Campo R.

    In Vitro Restoration of Colistin Susceptibility by Ivacaftor Synergy with Limited Reproducibility in a Murine Pneumonia Model.

    Antibiotics-Basel . 15(4): .

    [doi:10.3390/antibiotics15040414]

  • Baquero F, Cantón R, Alves Gama J, Rodríguez-Beltrán J.

    Antechokinetics, the kinetics of antimicrobial resistance molecules.

    Frontiers in Pharmacology . 17: 1792355-1792355.

    [doi:10.3389/fphar.2026.1792355]

  • Gil-Gil T, Berryhill BA, Witzany C, Regoes RR, Baquero F, Levin BR.

    The role of the innate immune system in shaping the dynamics of antimicrobial treatment.

    Biorxiv : The Preprint Server For Biology . : .

    [doi:10.64898/2026.04.09.717387]

  • Avendaño-Ortiz J, Ventosa-Cubillo J, Rodríguez-Jiménez C, Morales-Pérez D, Muñoz-Hernández R, Pavía-Ruz N, Navarro ML, Holguín Á.

    Perinatal HIV exposure is associated with long-term alterations in immune marker levels in children.

    Journal of Infection and Public Health . 19(4): 103168-103168. Number of citations: 1

    [doi:10.1016/j.jiph.2026.103168]

  • Józwiak G, Pla Verge M, Luraschi-Eggemann A, Mestiri C, McSorley E, Wilson-Owen D, La Fauci S, García-Castillo M, Delarze E, Fromm K, Munch L, Vogel C, Balasopoulos D, Cathomen G, Reiter S, Swiatkowski M, Totu R, Häussler S, Tenson T, Pagliara S, Cantón R, Greub G, Lisby G, Mullen W, Lockhart D, Cichocka D, Sturm A.

    Nanomotion-enabled ultra-rapid antibiotic susceptibility testing with magnetic bead-based pathogen enrichment for accelerated sepsis diagnostics.

    Scientific Reports . 16(1): .

    [doi:10.1038/s41598-026-44519-z]

  • Fernández-de-Bobadilla MD, Pérez-Cobas AE, Andremont A, Martínez JL, Baquero F, Lanza VF, Coque TM.

    The antimicrobial gut resistome of the Wayampi reveals a shared background of antibiotic and metal resistance genes with industrialized populations, underscoring the "robust-yet-fragile" architecture of human gut microbiomes.

    Microbiome . 14(1): .

    [doi:10.1186/s40168-026-02345-5]

  • Fluit AC, Bayjanov JR, Aguilar MD, Cantón R, Gilpin DF, Tunney MM, Ekkelenkamp MB.

    Qualitative analysis of genomic mutations and antibiotic susceptibility testing of Pseudomonas aeruginosa isolates from chronic lung infections.

    PLoS One . 21(3): .

    [doi:10.1371/journal.pone.0341613]

  • Romero-Rivera M, Fernández-de-Bobadilla MD, Beltrán M, del Campo R, Avendaño-Ortiz J, Herencias C.

    Genome assembly and functional predation analysis of novel Bdellovibrio isolates from human gut microbiota.

    Frontiers in Microbiology . 17: 1752098-1752098. Number of citations: 1

    [doi:10.3389/fmicb.2026.1752098]

  • Astiz N, Martínez de Aguirre P, Carlos S, Mbikayi S, Barquín D, Burgueño E, Holguín Á, Reina G.

    Long-term stability of dried blood spot samples for HIV diagnosis in adults from Kinshasa (Democratic Republic of Congo).

    JOURNAL OF CLINICAL VIROLOGY . 182: 105910-105910.

    [doi:10.1016/j.jcv.2025.105910]

  • Pérez-Martínez L, Romero L, Palacios E, Barbero R, Moreno-Blanco A, del Campo R, Blanco JR.

    Oral microbiota in patients with long COVID: A pilot study.

    Enfermedades Infecciosas Y Microbiologia Clinica (english Ed.) . 44(2): 503072-503072.

    [doi:10.1016/j.eimce.2026.503072]

  • Ramiro-Martínez P, Quinto I, Jaraba-Soto L, Lanza VF, Herencias-Rodríguez C, González Casanova A, Peña-Miller R, Rodríguez-Beltrán J.

    Plasmid mutation rates scale with copy number.

    PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA . 123(4): . Number of citations: 1

    [doi:10.1073/pnas.2526088123]

  • Cano-Pérez M, Caballero Pérez JD, Gómez García de la Pedrosa E, Gómez-López A.

    Biofilm Formation in Aspergillus fumigatus: A Comparative Study of Strains from Different Origins.

    Microorganisms . 14(2): . Number of citations: 1

    [doi:10.3390/microorganisms14020272]

  • Yu H, Carmona Y, Bouza V, González MK, Torres GE, Rodríguez VR, González AH, Kobayashi N, Aung MS, Ruiz-Garbajosa P, Cantón R, Pérez DQ.

    Rectal Colonization by Carbapenemase-Producing Enterobacterales in a Tertiary Care Hospital in Havana, Cuba.

    Antibiotics-Basel . 15(1): . Number of citations: 1

    [doi:10.3390/antibiotics15010109]

  • Inés JV, Martín CH, María Inmaculada DM, Iván PG, Stefano R, Esther P, Ana MB, Rosa DC, María Ángel GM, Roberto ÁL.

    Bacterial Metabolites in the Plasma of Type 1 Diabetes Patients: Acetate Levels Are Elevated and Correlate with Glycated Haemoglobin and Para-Cresol Is Associated with Liver Disturbances and Hypertension.

    INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES . 27(2): .

    [doi:10.3390/ijms27020989]

  • Corral Nieto Y, Fernández Pereira AG, Ventura-San Pedro L, Paredes SB, Pérez-Cobas AE, Perez-Lanzon M, Durand S, Moreno-Cruz P, Manrique L, Benítez-Fernández R, Leal Lassalle H, Nevzorova YA, Cubero FJ, Alechaga É, Pozo OJ, Boya P, Fuentes JM, Sica V, Kroemer G, Bravo-San Pedro JM.

    Identification of ACBP as a potential target in ciliopathic obesity through multi-omics network analysis.

    Nature Communications . 17(1): 362-362. Number of citations: 2

    [doi:10.1038/s41467-025-66235-4]

  • Martín-Pedraza L, Rodríguez-Martín E, De La Torre-Tarazona E, Moreno E, Pariente-Rodríguez R, Walo-Delgado PE, García-Pérez J, Díaz J, Luna L, Rodríguez-Dominguez M, Galán JC, Geraldine Rita C, Del Amo-de Palacios A, Navarro-Soler R, Fons M, Alcamí J, Moreno S, Villar LM, Serrano-Villar S.

    Contrasting immune responses in COVID-19: insights from healthcare workers and infected patients on plasmablast, pDC, and NK cell dynamics.

    Frontiers in Immunology . 16: 1693903-1693903.

    [doi:10.3389/fimmu.2025.1693903]

  • Aguilar G, Ruiz-Garbajosa P, Periañez Parraga L, Maroto-Díaz M, de Ceano-Vivas MDC, Villacampa Lordan A, Arranz Gonzalo S, de Lossada Juste A, Moya-Alarcón C, Gheorghe M, Torre-Cisneros J.

    Cost-Effectiveness Analysis of Aztreonam-Avibactam Compared with Colistin Plus Meropenem in Treating Metallo-Beta-Lactamase-Producing Enterobacterales Infections in Spain

    Infectious Diseases and Therapy . 15(1): 265-284. Number of citations: 2

    [doi:10.1007/s40121-025-01257-5]

  • Turnidge, John, Kahlmeter, Gunnar, Giske, Christian G, Canton, Rafael, Matuschek, Erika, Wootton, Mandy, Gatermann, Soren.

    How To: The Application and Analysis of Categorical Agreement in Antimicrobial Susceptibility Testing using EUCAST Breakpoints.

    CLINICAL MICROBIOLOGY AND INFECTION . 32(6): 916-920. Number of citations: 3

    [doi:10.1016/j.cmi.2025.12.018]