Biology and Evolution of Microorganisms

The Biology and Evolution of Microorganisms Group, whose head is Dr. Rafael Cantón and which is made up of nine other principal investigators as well as numerous pre- and post-doctoral researchers, technicians and other healthcare personnel, has participated in the last 5 years in 17 national and international research projects and in 15 contracts with pharmaceutical companies or companies dedicated to in vitro diagnostics. During this period of time this work has resulted in more than 190 publications in national and international journals with a high impact index and more than 11 doctoral theses. Likewise, more than 400 communications have been presented at numerous national and international congresses. And all this always seeking the highest excellence in the fields of population biology, antibiotic resistance, respiratory infection, microbiota, metagenomics and HIV.

Search for publications

Only original articles, editorials, guidelines.

  • de Córdoba-Ansón PF, Linares-Ambohades I, Baquero F, Coque TM, Pérez-Cobas AE.

    The Respiratory Tract Microbiome and Human Health.

    Microbial Biotechnology . 18(5): .

    [doi:10.1111/1751-7915.70147]

  • Arredondo-Alonso S, Pöntinen AK, Gama JA, Gladstone RA, Harms K, Tonkin-Hill G, Thorpe HA, Simonsen GS, Samuelsen Ø, Johnsen PJ, Corander J.

    Plasmid-driven strategies for clone success in Escherichia coli.

    NATURE COMMUNICATIONS . 16(1): 2921-2921.

    [doi:10.1038/s41467-025-57940-1]

  • Becerra-Aparicio F, Gómez-Zorrilla S, Hernández-García M, Xanthopoulou K, Gijón D, Siverio A, Berbel D, Cercenado E, Rivera A, De Malet A, Xercavins M, Ruiz De Gopegui E, Canoura-Fernández L, Martínez JA, Seral C, Del Pozo JL, Cotarelo M, Ponz R, Higgins PG, Durán-Jordà X, Cantón R, Oliver A, Horcajada JP, Ruiz-Garbajosa P.

    Whole Genome Sequencing Analysis of Klebsiella pneumoniae Isolates from Health Care-Associated Bacteremia of Urinary Origin in Spain: Findings from the Multicenter ITUBRAS-2 Cohort Study.

    Open forum infectious diseases . 12(4): .

    [doi:10.1093/ofid/ofaf164]

  • Ismail AS, Berryhill BA, Gil-Gil T, Manuel JA, Smith AP, Baquero F, Levin BR.

    The tradeoffs between persistence and mutation rates at sub-inhibitory antibiotic concentrations in Staphylococcus aureus.

    Microbiology spectrum . 13(4): .

    [doi:10.1128/spectrum.02479-24]

  • Serrano-Tomás MI, Cabello M, Moreno-Nuñez P, Sanz JC, Cantón R, Sánchez-Díaz AM.

    Invasive pneumococcal disease in a tertiary hospital in Madrid: are we using pneumococcal vaccine correctly?

    Enfermedades Infecciosas Y Microbiologia Clinica (english Ed.) . 43(4): 210-214.

    [doi:10.1016/j.eimce.2025.03.009]

  • Peñalva G, Cantón R, Pérez-Rodríguez MT, González-López JJ, Rodríguez-Baño J, Barrio-Tofiño ED, Kirkegaard-Biosca C, Sánchez-Romero I, Gutiérrez-Villanueva A, Marrodán-Ciordia T, Guerra-Laso JM, Rosario-Quintana CD, Suárez-Hormiga L, Cámara J, Puig-Asensio M, Heredero E, Sepúlveda MA, Rodríguez-Díaz JC, Merino E, Cercenado E, Villa S, Siller M, Arnaiz F, Seral C, Lepe JA, Cisneros JM, Paño-Pardo JR.

    Burden of bacterial antimicrobial resistance among hospitalised patients in Spain: findings from three nationwide prospective studies.

    LANCET REGIONAL HEALTH-EUROPE . 51: 101220-101220.

    [doi:10.1016/j.lanepe.2025.101220]

  • Vicente-Santamaría S, Tabares-González A, Gascón-Galindo C, Tutau-Gómez C, Álvarez-Beltrán M, Muñoz-Codoceo RA, Rubio-Murillo M, De-Los-Santos M, Salcedo-Lobato E, Masip-Simó E, García-Romero R, Fernández-Lorenzo AE, Moreno-Álvarez A, Serrano-Nieto J, Hierro-Llanillo L, Loverdos-Eseverri I, Crehuá-Gaudiza E, Juste-Ruiz M, Blitz-Castro E, Morales-Tirado A, López-Cárdenes CM, Bousoño-García C, González-Jiménez D.

    Current situation of pediatric cystic fibrosis-related liver disease: results of a Spanish nationwide study.

    EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY . 37(4): 505-509.

    [doi:10.1097/MEG.0000000000002917]

  • Ruedas-López A, Tato M, Lerma L, Esteban J, Muñoz-Egea MC, Toro C, Domingo D, Prados-Rosales R, López-Roa P.

    Infection model of THP-1 cells, growth dynamics, and antimicrobial susceptibility of clinical Mycobacterium abscessus isolates from cystic fibrosis patients: Results from a multicentre study.

    Plos One . 20(3): .

    [doi:10.1371/journal.pone.0319710]

  • Monge-Maillo B, Roger-Zapata D, Dronda F, Carrillo E, Moreno J, Corbacho-Loarte MD, Gayoso Cantero D, Martín O, Chamorro-Tojeiro S, Perez-Molina JA, Norman F, González-Sanz M, López-Vélez R.

    Case Report: Long-Term Follow-Up of Visceral Leishmaniasis and HIV Coinfected Patients Without Relapse: Lymphoproliferative Response After Stimulation with Soluble Leishmania Antigen.

    Microorganisms . 13(3): .

    [doi:10.3390/microorganisms13030686]

  • Meyer R, Arpe L, Kansu A, Kelly V, Lindley K, O'Meara M, Del Carmen Rivero M, van Zundert S, Vicente-Santamaría S, Žaja O, Oliveros E, Olivier L, Joosten K.

    Gastrointestinal changes in paediatric malnutrition that may impact on nutrition choice.

    Frontiers in Pediatrics . 13: 1523613-1523613.

    [doi:10.3389/fped.2025.1523613]

  • Blasco L, Ibarguren-Quiles C, López-Causape C, Armán L, Barrio-Pujante A, Bleriot I, Pacios O, Fernández-García L, Ortiz-Cartagena C, Cant?n R, Oliver A, Tomás M.

    Study of the probability of resistance to phage infection in a collection of clinical isolates of Pseudomonas aeruginosa in relation to the presence of Pf phages.

    Microbiology spectrum . 13(3): .

    [doi:10.1128/spectrum.03010-24]

  • Castillo-Polo JA, Hernández-García M, Maruri-Aransolo A, Morosini MI, Ruiz-Garbajosa P, Cantón R.

    Cefiderocol AST in a real-life Klebsiella pneumoniae collection: challenges in the ATU range.

    The Journal of antimicrobial chemotherapy . 80(3): 797-801.

    [doi:10.1093/jac/dkae477]

  • Bhowmick T, Canton R, Pea F, Quevedo J, Santerre Henriksen A, Timsit JF, Kaye KS.

    Cefepime-enmetazobactam: first approved cefepime-ß- lactamase inhibitor combination for multi-drug resistant Enterobacterales.

    Future Microbiology . 20(4): 1-10.

    [doi:10.1080/17460913.2025.2468112]

  • Martins-Oliveira I, Pérez-Viso B, Gomes R, Abreu D, Silva-Dias A, Cantón R, Pina-Vaz C.

    Phenotypic Ultra-Rapid Antimicrobial Susceptibility Testing for Ceftazidime-Avibactam: In Support of Antimicrobial Stewardship.

    Microorganisms . 13(2): .

    [doi:10.3390/microorganisms13020414]

  • Alarcón-Iniesta H, de Arana G, López-Valls M, Pardo D, Escalona-Noguero C, Rodríguez C, Castellanos M, Cobelo S, Martínez-Ramírez I, Camarero J, Heras SL, de Vicente J, Valera A, Smith W, Bernardo-Gavito R, Cantón R, Galán JC, Granados D, Miranda R, Guerrero H, Sot B.

    CRISPR-associated Plasmonic Colorimeter Method (Ca-PCM): A real-time RGB detection system for gold nanoparticles-based nucleic acid biosensors.

    ANALYTICA CHIMICA ACTA . 1338: 343601-343601.

    [doi:10.1016/j.aca.2024.343601]

  • Colmenarejo C, Rodríguez-Jiménez C, Navarro FJ, Mateo AB, Pellejero EM, Belda-Moreno RM, Ureña-Méndez R, Pérez-Serrano R, Illescas S, Ramón Muñoz-Rodríguez J, Del Campo R.

    One-year monitorization of the gut colonization by multidrug resistant bacteria in elderly of a single long-term care facility.

    Jac-Antimicrobial Resistance . 7(1): .

    [doi:10.1093/jacamr/dlaf008]

  • Artiles Medina A, Subiela JD, Tagalos Muñoz A, Tato Díez M, Mínguez Ojeda C, López Curtis D, Sánchez González Á, Brasero Burgos J, Serna-Céspedes A, Gómez Dos Santos V, Jiménez Cidre MÁ, Burgos Revilla FJ.

    Clinical outcomes of BCG infections in patients undergoing intravesical immunotherapy for non-muscle-invasive bladder cancer: a systematic review and meta-analysis.

    Minerva Urology And Nephrology . 77(1): 13-24.

    [doi:10.23736/S2724-6051.24.05910-X]

  • Baquero F.

    Neglected Human Risk Factors Determining Sustainable Health by Microbial Causes: Individual Versus Social Conducts, Scientific Versus Stultified Behaviour.

    Microbial Biotechnology . 18(2): .

    [doi:10.1111/1751-7915.70097]