Biology and Evolution of Microorganisms

The Biology and Evolution of Microorganisms Group, whose head is Dr. Rafael Cantón and which is made up of nine other principal investigators as well as numerous pre- and post-doctoral researchers, technicians and other healthcare personnel, has participated in the last 5 years in 17 national and international research projects and in 15 contracts with pharmaceutical companies or companies dedicated to in vitro diagnostics. During this period of time this work has resulted in more than 190 publications in national and international journals with a high impact index and more than 11 doctoral theses. Likewise, more than 400 communications have been presented at numerous national and international congresses. And all this always seeking the highest excellence in the fields of population biology, antibiotic resistance, respiratory infection, microbiota, metagenomics and HIV.

Search for publications

Only original articles, editorials, guidelines.

  • García-Ortega A, Del-Campo-Moreno R, Sánchez V, Hervás-Marín D, Avendaño-Ortiz J, Rivas-Guerrero A, Muriel A, Pedro-Tudela A, Taberner-Lino L, De-Juana C, Barreiro E, Lobo-Beristain JL, Jiménez D, Otero Candelera R.

    Evaluation of microbial-derived metabolites in patients with acute pulmonary embolism: findings from the MICTEP study.

    Erj Open Research . 11(6): .

    [doi:10.1183/23120541.00541-2025]

  • Espinosa-Del-Barrio L, Gómez G de la Pedrosa E, Álvarez-Díaz N, Guzmán Martínez J, Corbacho Loarte MD, Escudero Sánchez R, Martín-Dávila P, Fortún Abete J, Cobo Reinoso J, Pintado García V, Gioia F.

    Aspergillus Endocarditis in Native Valves in Non-Traditional Hosts: A Systematic Review of a Case in a Patient with CREST Syndrome and Advanced Liver Cirrhosis.

    JOURNAL OF FUNGI . 11(12): .

    [doi:10.3390/jof11120836]

  • Torumkuney D, Canton R, Pitart C, Sanguinetti M, Vismara C, Farina C, Sambri V, Hawser S, Manoharan A.

    Results from the Survey of Antibiotic Resistance (SOAR) 2018-21 in Italy and Spain: data based on CLSI, EUCAST (dose-specific) and pharmacokinetic/pharmacodynamic (PK/PD) breakpoints.

    The Journal of antimicrobial chemotherapy . 80(Supplement_3): .

    [doi:10.1093/jac/dkaf283]

  • Blanco JR, Del Campo R, Avendaño-Ortiz J, Laguna-Olmos M, Carnero A.

    The Role of Microbiota in Ovarian Cancer: Implications for Treatment Response and Therapeutic Strategies.

    Cells . 14(22): .

    [doi:10.3390/cells14221813]

  • Bastón-Paz N, Moreno-Blanco A, Palacios E, Olavarrieta L, Galeano J, Garriga M, Máiz L, Vicente-Santamaría S, Oteo-Iglesias J, López-Causapé C, Fuentes I, Oliver A, Cantón R, del Campo R, de Dios-Caballero J.

    Exploring the Complexities of Intestinal and Pulmonary Microbiota in Cystic Fibrosis: A Multi-Omics Approach.

    RESPIRATORY MEDICINE . 248: 108331-108331.

    [doi:10.1016/j.rmed.2025.108331]

  • Valadés-Alcaraz A, Medina-Sánchez C, Reinosa R, Ventosa-Cubillo J, Ventosa-Cubillo V, Holguín Á.

    Design and characterisation of high-affinity aptamers for detecting HIV integrase.

    ANALYTICA CHIMICA ACTA . 1373: 344545-344545.

    [doi:10.1016/j.aca.2025.344545]

  • Canton R, Halperín AV.

    Diagnostic stewardship in sepsis: minding the gap from the microbiology lab to ward.

    REVISTA ESPANOLA DE QUIMIOTERAPIA . 38 Suppl 1: 11-20.

    [doi:10.37201/req/s01.02.2025]

  • Guadarrama-Orozco KD, Esquivel-Hernández DA, Islas-Tolentino MÁ, Husain FM, Quezada H, García-Reyes S, Franco B, Marroquin-Mendiola DL, Lucero-Gil MG, Olvera-Falfan LP, Estrada-Velasco ÁY, Fabián Del Olmo MJ, Cocotl-Yañez M, Tomas M, Peña-Ocaña BA, Maeda T, Khan A, Arshad M, Cantón R, Oliver A, Kidd TJ, Valdez A, Cadet F, Toya S, Fontaine N, Ceapa CD, Kirigo J, Wood TK, García-Contreras R.

    Challenging the paradigm: non-canonical exoprotease cheating in clinical Pseudomonas aeruginosa isolates.

    FEMS MICROBIOL ECOL . 101(11): .

    [doi:10.1093/femsec/fiaf106]

  • Asensi-Díaz E, Barbero Del Olmo L, Urrutia P, Lario A, Gómez-G de la Pedrosa E, García-Ruiz de Morales AG, Martín-Dávila P, Fortún J.

    When Fungal Prophylaxis Fails: A Rare Case of Rhodotorula mucilaginosa Fungemia with Suspected Abdominal Origin.

    JOURNAL OF FUNGI . 11(10): .

    [doi:10.3390/jof11100723]

  • Halperin AV, Escudero R, García-Castillo M, Cardenas-Isasi MJ, Gioia F, Cobo J, Sánchez-Díaz AM, Cantón R.

    Randomized controlled diagnostic trial to assess dRAST time to result and its utility for antimicrobial stewardship recommendation in bacteremic patients.

    Microbiology spectrum . 13(10): .

    [doi:10.1128/spectrum.00288-25]

  • Labiod N, Sánchez-Seco MP, Goikoetxea J, Zurita ND, Norman FF, Martínez MM, Alonso PA, Hernández-Betancor A, Sempere-Alcocer MA, Moure Z, Ocete MD, Vicente MR, de la Calle-Prieto F, Gallego M, Domingo LC, Galán JC, Camprubí-Ferrer D, Meilán C, Perez-Hernandez I, Cabezón I, Hernández FJ, Bernal E, Vázquez A.

    Case series of Oropouche fever among travellers returning from Cuba to Spain, 2024.

    Eurosurveillance . 30(41): .

    [doi:10.2807/1560-7917.ES.2025.30.41.2400719]

  • Rodriguez-Tierno S, Sáez de la Fuente J, Fuertes Pina L, Escudero-Sánchez R, Ruiz-Garbajosa P, Guijarro Martínez P, Gioia F, Pintor Recuenco MDR, Álvarez-Díaz A.

    Real-life experience with use of cefiderocol in non-critically ill patients in a tertiary care hospital.

    Enfermedades Infecciosas Y Microbiologia Clinica (english Ed.) . 43(8): 510-514.

    [doi:10.1016/j.eimce.2025.05.009]

  • Rico-Caballero V, Romero-Rivera M, Moreno-Blanco A, Aira A, Casals-Pascual C, Rodríguez-Jiménez C, Quereda C, Soriano A, Del Campo R.

    Fecal microbiota transplant as treatment for recurrent urinary tract infections: a proof-of-concept study.

    EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES . 44(10): 2549-2554.

    [doi:10.1007/s10096-025-05202-9]

  • Daneri L, Urbano A, Escudero-Sánchez R, Halperin AV, Moreno-Blanco A, Corbacho MD, Suárez-Carantoña C, Rodríguez-Jiménez C, Serrano-Villar S, Campo RD, Cobo J.

    Lyophilised fecal microbiota transfer in capsules for recurrent Clostridioides difficile infection.

    INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS . 66(4): 107561-107561.

    [doi:10.1016/j.ijantimicag.2025.107561]

  • Sastre-Femenia MÀ, Fernández-Muñoz A, Gomis-Font MA, Taltavull B, López-Causapé C, Arca-Suárez J, Martínez-Martínez L, Cantón R, Larrosa N, Oteo-Iglesias J, Oliver A.

    Spanish nationwide survey of Pseudomonas aeruginosa cefiderocol susceptibility and resistance mechanisms.

    INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS . 66(4): 107563-107563.

    [doi:10.1016/j.ijantimicag.2025.107563]

  • Avendaño-Ortiz J, Tribaldo A, Ballestero L, Gómez LA, Gracia I, Rodríguez JF, Ramírez NB, Bodoque-Villar R, Vaz-Salgado MÁ, Del Campo R, Redondo-Calvo FJ.

    Antimicrobial Activity of Natural Extracts Against Catheter-Colonizing Methicillin-Resistant Staphylococcus aureus Clinical Isolates.

    Biomedicines . 13(9): .

    [doi:10.3390/biomedicines13092150]

  • Pérez-Molina JA, Moreno E, Crespillo-Andújar C, Chamorro-Tojeiro S, Arsuaga M, Olavarrieta L, Martín O, Monge-Maillo B, Norman F, Lanza VF, Serrano-Villar S.

    Chagas disease induces gut microbial metabolic stress: Disruption of energy and nucleotide pathways and partial reversal by antiparasitic therapy (TRIPOBIOME-2 study).

    TRAVEL MEDICINE AND INFECTIOUS DISEASE . 67: 102881-102881.

    [doi:10.1016/j.tmaid.2025.102881]

  • Boattini M, Aceti A, Bastos P, Mavromanolaki VE, Maraki S, Spiliopoulou A, Kakouris V, Kalchev Y, Budimir A, Bedenic B, Rubic Z, Licker M, Musuroi C, Juhász E, Kristóf K, Pirs M, Velimirovic I, Berktold M, Liptáková A, Krajcíková A, Drevinek P, Gryndlerova A, Brzychczy-Wloch M, Olechowska-Jarzab A, Bielec F, Brauncajs M, Podsiadly E, Nurzynska G, Zalas-Wiecek P, Michalska A, Riesbeck K, Andersson HS, Tønjum T, Berild JC, Leegaard TM, Rasmussen AN, Schønning K, Glöckner S, Rödel J, Badr MT, Häcker GA, Stark D, Hamprecht A, Dudakova A, Jantsch J, Mancini S, Quiblier C, Jacot D, Greub G, Ferniani T, Ambretti S, Calvo M, Stefani S, Schade R, Yusuf E, van Kleef-van Koeveringe S, Vandamme S, Verroken A, Rodriguez-Villalobos H, Duigou F, Corvec S, Floch P, Massip C, Chainier D, Barraud O, Louissaint MB, Mizrahi A, Ali S, Doyle M, Egan C, McNicholas S, Colomina-Rodriguez J, Torres I, Gillaranz Luengo R, Larrosa Escartín MN, Viñado Perez MB, Halperin AV, Fuente García S, Cantón R, Seruca M, Santos Mendes V, Carvalho D, Cavallo R, Melo Cristino J, Costa C, Bianco G.

    A European survey on anaerobes from paediatric blood cultures: a comparative analysis with adults.

    EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES . 44(9): 2207-2217.

    [doi:10.1007/s10096-025-05185-7]