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Biology and Evolution of Microorganisms

The Biology and Evolution of Microorganisms Group, whose head is Dr. Rafael Cantón and which is made up of nine other principal investigators as well as numerous pre- and post-doctoral researchers, technicians and other healthcare personnel, has participated in the last 5 years in 17 national and international research projects and in 15 contracts with pharmaceutical companies or companies dedicated to in vitro diagnostics. During this period of time this work has resulted in more than 190 publications in national and international journals with a high impact index and more than 11 doctoral theses. Likewise, more than 400 communications have been presented at numerous national and international congresses. And all this always seeking the highest excellence in the fields of population biology, antibiotic resistance, respiratory infection, microbiota, metagenomics and HIV.

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Only original articles, editorials, guidelines.

  • Chaves-Blanco L, Illescas-López M, Fuentes A, Carracedo R, Delgado-Iribarren A, Vázquez Blanquiño A, Blázquez AM, Sáez R, Miqueleiz A, Vidal MLR, Tosco T, Gómez C, Moldes L, Calvo N, Pérez Rodríguez L, Trigo M, Ocete MD, Alcaraz MJ, Iborra MA, García J, Blas JJ, Vallejo AM, Alberola Romano A, Illescas S, Rodriguez JC, Alonso R, Cámara M, Navarro MD, Núñez ML, Del Amor Espín MJ, Beteta A, Cascales E, Soria LM, Gacinuño S, Sandoval M, Cortizo S, Ordóñez P, Liendo P, Pérez-Ruiz M, Álvarez Argüelles M, García F, Rodriguez I, Gómez C, Elorduy L, Hernández Febles M, González-Praetorius A, Liébana C, Molina ML, Salicio Y, Macho M, Becerril B, Franco Álvarez F, Falces I, Algarate S, Gude MJ, Pablo D, Lara MM, Montiel N, Freyre C, Galán JC, Pérez AB, Lorenzo B, Fraile P, Sánchez-Yebra W, Viciana I, Sampedro A, Lozano MDC, Domínguez Castaño A, Ramírez E, Beltrán I, Martín T, Puerta A, Tajada P, Panés P, Martín A, Hurtado JC, López Braos J, Arjona F, Miró E, Ruiz M, Ramírez M, Gil Fortuño M, González Pellicer R, Acedo JM, Anel Pedroche J, Infante Urrios A, Domínguez V, Arán Tohá G, Martínez Macías O, Orta Mira N, Torres Sopena L, Cantudo P, Hernández MA, Arroyo Serrano T, Rando A, Garrido M, Fernández G, de Salazar A, Aguilera A, García F.

    Implementation of quantitative HBsAg testing in clinical microbiology laboratories in Spain: Results from a national GEHEP-SEIMC survey.

    Enfermedades Infecciosas Y Microbiologia Clinica (english Ed.) . 44(7): 503215-503215.

    [doi:10.1016/j.eimce.2026.503215]

  • Dezza FC, Pulido LB, Borreguero IB, Pérez FD, Jiménez VP, de la Rosa Riestra S, Bravo-Ferrer JM, Palacios-Baena ZR, Zuñiga MÁL, Cobo F, Gómez-Junyent J, Horcajada JP, Merino E, Parra M, López-Contreras J, Rivera A, Regueiro DS, Garcia MP, Cardenas SL, Sánchez MCG, Camacho IP, Ramos SMM, Jiménez EL, García AIA, Pérez-Rodríguez MT, Sousa A, Ruiz MS, de Las Revillas Almajano FA, Pérez LG, Agirre JG, Cano Á, Martínez-Marcos FJ, País MJG, Sánchez RE, de la Villa S, Ara JRY, Esteban-Moreno MÁ, Ruiz-Sancho A, Aragón MP, Fernández JA, Blandino AMB, Vilchez-Rueda HH, Álvarez-Marín R, Palacios AR, Vázquez EG, Álvarez EN, Rosso-Fernández C, Gutiérrez-Gutiérrez B, Pascual Á, López-Cerero L, Rodríguez-Baño J.

    Temocillin versus carbapenems for bacteraemia due to third-generation cephalosporin-resistant Enterobacterales in Spain (ASTARTÉ): a multicentre, phase 3, open-label, non-inferiority, randomised clinical trial.

    LANCET . 408(10553): 430-439.

    [doi:10.1016/S0140-6736(26)00760-9]

  • Boattini M, Bastos P, Gartzonika K, Christaki E, Mavromanolaki VE, Maraki S, Spiliopoulou A, Giormezis N, Lengerova G, Kalchev Y, Budimir A, Bedenic B, Rubic Z, Saskor A, Milanovic K, Licker M, Musuroi C, Juhász E, Kristóf K, Pirs M, Velimirovic I, Berktold M, Krajcíková A, Gryndlerova A, Drevinek P, Sedláková MH, Kolár M, Brzychczy-Wloch M, Olechowska-Jarzab A, Brauncajs M, Bielec F, Seliga-Gasior D, Podsiadly E, Riesbeck K, Andersson HS, Tønjum T, Berild JC, Leegaard TM, Rasmussen AN, Schønning K, Glöckner S, Rödel J, Posadas-Cantera S, Badr MT, Kintzinger T, Schaumburg F, Thelen P, Hamprecht A, Dudakova A, Jantsch J, Hoffmann K, Kaasch AJ, Jacot D, Greub G, Landi J, Ambretti S, Comini S, Ranieri SC, Serretiello E, Franci G, Fasciana T, Schade R, Yusuf E, Koeveringe SVKV, Vandamme S, Verroken A, Rodriguez-Villalobos H, Strubbe G, Vandendriessche S, Rabeau P, Corvec S, Dubois D, Floch P, Chainier D, Barraud O, Mizrahi A, Bacho C, Bouchiat C, Fatah T, Marchandin H, Jean-Pierre V, Ali S, Donnell SO, Doyle M, Ramsamaroo Z, Egan C, McNicholas S, Helgason KO, Öngen B, Karapinar BA, Oyardi Ö, Aksu B, Colomina-Rodriguez J, Torres I, Luengo RG, Escartín MNL, Perez MBV, Halperin AV, Cantón R, Seruca M, Mendes VS, Volovetska Y, Cristino JM, Costa C, Bianco G.

    Epidemiology and antimicrobial resistance patterns of Aeromonas species in Europe, 2020-2024 (AEuROMONAS).

    DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE . 115(4): 117384-117384.

    [doi:10.1016/j.diagmicrobio.2026.117384]

  • Casado JL, Vizcarra P, Izuzquiza I, Rodriguez-Dominguez MJ, Romero-Hernandez B, Moreno A, Vallejo A.

    Long-Term Serologic Outcomes Following Treatment of Syphilis in People With HIV: A Prospective Cohort Study.

    CLINICAL INFECTIOUS DISEASES . 83(1): 174-182.

    [doi:10.1093/cid/ciag193]

  • Cantón R, Lim AN, Cortés V, Díaz-Regañón J.

    Uncomplicated Urinary Tract Infections: From an Invisible Impact to a Visible Change in Complex Care.

    CLINICAL INFECTIOUS DISEASES . 82(6): .

    [doi:10.1093/cid/ciaf705]

  • Nguyen NM, Weber A, Xavier BB, Rodríguez-Ruiz JP, Kola A, Behnke M, Geffers C, Goossens H, Harbarth S, Bonten M, Canton R, Gastmeier P, Glupczynski Y, Maechler F, Malhotra-Kumar S, On Behalf Of The R-Gnosis Wp Starcs Wp And Mistar Wp Study Groups.

    Genomic surveillance reveals long-term endemicity and outbreak potential of Klebsiella pneumoniae sequence type 48 in a German hospital and its global context.

    Microbial Genomics . 12(7): .

    [doi:10.1099/mgen.0.001707]

  • Paniagua-García M, Bernal-Aznar JM, Gkrania-Klotsas E, Soper I, Montoya MLP, Reynaga EA, Valiente A, Domínguez-Jiménez MC, Lombardi A, Navarro M, Cobo F, Freire M, Halperin AV, Alsina L, Garzaro M, Christ SCC, Laporte-Amargos J, de Gopegui-Bordes ER, Martínez-Martínez L, Oliveira MS, García-López V, Martinez-Marcos FJ, Cendejas E, Del Arco-Jiménez A, Chávez-Caballero M, López-Cardenas S, Rodríguez-Iglesias MA, Alonso CA, Giannella M, Gimeno-Gascón A, Sánchez-Suero P, Jiménez-Jorge S, Pachón J, Pachón-Ibáñez ME, Cordero E.

    Campylobacter spp Bloodstream Infections in Immunocompetent vs Immunodeficient Patients: A Multinational Cohort Study (2009-2024).

    Open Forum Infectious Diseases . 13(7): .

    [doi:10.1093/ofid/ofag380]

  • Norman FF, Gomez-Garcia de la Pedrosa E, Serrador M, González-López JJ, Gonzalez-Sanz M, Martín-Dávila P, Lora-Plaza A, Zaragoza O, Quereda C.

    Cryptococcus neoformans meningoencephalitis, chorioretinitis and recurrent obstructive pneumonia in an immunocompetent migrant from Paraguay.

    JOURNAL OF TRAVEL MEDICINE . 33(5): .

    [doi:10.1093/jtm/taag043]

  • Yang Q, Tuon FF, Shah S, Kamat S, Mohamed N, Stone GG, Perez KK, Cantón R.

    In vitro activity of aztreonam/avibactam and comparators against Enterobacterales isolates from patients with hospital-acquired pneumonia, ventilator-associated pneumonia, and complicated intra-abdominal infections (ATLAS, 2021-2022).

    JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY . 81(7): .

    [doi:10.1093/jac/dkag198]

  • Bianco G, Bastos P, Gartzonika K, Christaki E, Mavromanolaki VE, Maraki S, Spiliopoulou A, Giormezis N, Lengerova G, Kalchev Y, Budimir A, Bedenic B, Rubic Z, Saskor A, Milanovic K, Licker M, Musuroi C, Juhász E, Kristóf K, Pirs M, Velimirovic I, Berktold M, Krajcíková A, Gryndlerova A, Drevinek P, Sedláková MH, Kolár M, Brzychczy-Wloch M, Olechowska-Jarzab A, Brauncajs M, Bielec F, Seliga-Gasior D, Podsiadly E, Riesbeck K, Andersson HS, Tønjum T, Berild JC, Leegaard TM, Nellemann Rasmussen A, Schønning K, Glöckner S, Rödel J, Posadas-Cantera S, Badr MT, Kintzinger T, Schaumburg F, Thelen P, Hamprecht A, Dudakova A, Jantsch J, Hoffmann K, Kaasch AJ, Jacot D, Greub G, Landi J, Ambretti S, Comini S, Chiatamone Ranieri S, Serretiello E, Franci G, Fasciana T, Schade R, Yusuf E, van Kleef-van Koeveringe S, Vandamme S, Verroken A, Rodriguez-Villalobos H, Strubbe G, Vandendriessche S, Rabeau P, Corvec S, Dubois D, Massip C, Chainier D, Barraud O, Mizrahi A, Bacho C, Bouchiat C, Fatah T, Marchandin H, Jean-Pierre V, Ali S, O'Donnell S, Doyle M, Ramsamaroo Z, Egan C, McNicholas S, Helgason KO, Öngen B, Karapinar BA, Oyardi Ö, Aksu B, Colomina-Rodriguez J, Torres I, Gilarranz Luengo R, Larrosa Escartín MN, Viñado Perez MB, Halperin AV, Cantón R, Seruca M, Santos Mendes V, Volovetska Y, Melo Cristino J, Costa C, Boattini M.

    Minor non-fermenting Gram-negative bacilli in Europe, 2020-2024 (MINOFEu).

    International Journal of Antimicrobial Agents . 67(6): 107772-107772.

    [doi:10.1016/j.ijantimicag.2026.107772]

  • Samuelsen Ø, López-Causapé C, Aarestrup FM, Bortolaia V, Brouwer MSM, Cantón R, Egli A, Grad YH, Hamprecht A, Haussler S, Holt KE, Hopkins KL, Howden BP, Jeannot K, Kahlmeter G, Köser CU, Mathers AJ, Naas T, Pournaras S, Ruppé E, Schön T, Stoesser N, Turnidge J, Werner G, Wright GD, Giske CG, Oliver A.

    The role of whole genome sequencing in antimicrobial susceptibility prediction of bacteria: 2025 update from the European Committee on Antimicrobial Susceptibility Testing Subcommittee.

    CLINICAL MICROBIOLOGY AND INFECTION . 32(7S): .

    [doi:10.1016/j.cmi.2026.05.012]

  • Halperin AV, Gómez-León S, Escudero-Sánchez R, Corbacho-Loarte MD, Suárez-Carantoña C, Saez de la Fuente J, Retamar-Gentil P, Cantón R.

    Structured integration of rapid antimicrobial susceptibility testing and antimicrobial resistance detection into an antimicrobial stewardship programme for bacteraemia.

    JAC-Antimicrobial Resistance . 8(3): .

    [doi:10.1093/jacamr/dlag067]

  • Muñoz Báez P, Illescas López M, de Salazar A, Falces Romero I, Pinto A, Portilla I, Masiá M, Peraire J, Alemán Valls MR, Sanchiz M, Iborra A, Baza B, Aguilera A, Olalla J, Espinosa N, Iribarren JA, Gisbert L, Imaz A, Montero M, Navarro Marcotegui M, Suárez-García I, Riera M, Pérez Elias MJ, Galán JC, García Fraile LJ, Sanz J, Ibarra Ugarte S, Bernal E, Blanco JR, Navarro G, Martínez O, Viciana Ramos MI, Mohamen-Balghata MO, Delgado E, Thompson MM, Moreno C, CoRIS C, Fuentes A, García F.

    Beyond Surveillance Mutations: Long-Term Trends and Clinical Relevance of Transmitted HIV Drug Resistance in Spain (2007-2023).

    Open Forum Infectious Diseases . 13(6): .

    [doi:10.1093/ofid/ofag296]

  • Almeida-Santos AC, Tedim AP, Duarte B, Pereira AP, Silva LM, Teixeira J, Castro AP, Roer L, Hammerum AM, Hasman H, Coque TM, Novais C, Freitas AR, Peixe L.

    Twelve years of genomic surveillance of vancomycin-resistant Enterococcus faecium: emergence of linear vanA and bacteriocin-carrying plasmids challenging infection control.

    Genome Medicine . 18(1): .

    [doi:10.1186/s13073-026-01656-4]

  • Cantón R, García-Castillo M, Hernández-García M, Sastre-Femenía MÀ, López-Causapé C, Ruiz-Garbajosa P, García Labrador L, Longshaw C, Oliver A.

    Cefiderocol activity against multidrug-resistant isolates from the PERSEUS study: relationship between cefiderocol minimum inhibitory concentration and clinical outcomes.

    JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY . 81(6): .

    [doi:10.1093/jac/dkag164]

  • Alberola A, de Salazar A, Fuentes A, Carracedo R, Illescas-López M, Rodríguez Baños MDC, Freyre C, Becerril B, Viciana I, López-Rodríguez I, Montiel N, Domínguez Castaño AM, Luzón-García MP, Ramírez Arellano E, Liébana-Martos C, Franco Álvarez de Luna F, Lozano MDC, Palop B, Sampedro A, Pérez AB, Algarate S, Rojo Alba S, Fraile P, Ocete D, Alcaraz MJ, Rodríguez JC, Hernández-Felices FJ, Martínez O, Domínguez V, Orta N, Gómez D, Cortell C, Camacho J, Sabater S, Iglesias Sánchez LÁ, Martín Y, Vallejo A, Molina L, Aroca M, Castro B, Lara M, Pena MJ, Rodríguez-Fernández A, González Praetorius A, Blas JJ, Beteta A, Gómez C, Rodríguez MJ, Illescas S, Abreu M, García Díez J, Beltrán I, Sandoval Torrientes M, Sáez R, Martín T, Tajada Alegre P, Lorenzo B, García Valero MT, Jiménez Sansegundo I, García-de Cruz S, Garcinuño S, Sáiz MÁ, Muñoz S, Fernández I, Lorenzo Juanes HM, Vidal-Acuña MR, Moldes LM, Calvo N, Trigo M, Gude MJ, Ordóñez P, Cortizo S, Blasco M, Sigcha M, Falces I, Galán JC, Arribi A, Alonso R, Iborra A, Del Amor Espín MJ, Cascales E, Pérez C, Fernández P, Navarro MD, Nuñez ML, Galán Ros J, Gil-Gallardo LJ, Miqueleiz A, Reina G, Elorduy L, Macho M, Gómez C, Liendo P, Salicio Y, Aguilera A, García F.

    Nationwide Implementation of Double Reflex Testing for Hepatitis Delta in Spain: Results From the Retrospective Phase of the Spain-DDR Study.

    ALIMENTARY PHARMACOLOGY & THERAPEUTICS . 63(10): 1390-1397. Number of citations: 3

    [doi:10.1111/apt.70543]

  • Baquero F, Pérez-Cobas AE, Lanza VF.

    Ecogenomic kinetics: wandering bacterial populations stumbling upon niches.

    TRENDS IN MICROBIOLOGY . 34(5): 468-471.

    [doi:10.1016/j.tim.2026.03.009]

  • De Salazar A, Negredo A, Galán JC, Del Peso T, Illescas M, Martínez-García L, Gimeno C, García F, Sánchez-Seco MP.

    Readiness Level of Spanish Labs to Detect Mpox Clade Ib: A Nationwide EQA.

    JOURNAL OF MEDICAL VIROLOGY . 98(5): .

    [doi:10.1002/jmv.70948]