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Biology and Evolution of Microorganisms

The Biology and Evolution of Microorganisms Group, whose head is Dr. Rafael Cantón and which is made up of nine other principal investigators as well as numerous pre- and post-doctoral researchers, technicians and other healthcare personnel, has participated in the last 5 years in 17 national and international research projects and in 15 contracts with pharmaceutical companies or companies dedicated to in vitro diagnostics. During this period of time this work has resulted in more than 190 publications in national and international journals with a high impact index and more than 11 doctoral theses. Likewise, more than 400 communications have been presented at numerous national and international congresses. And all this always seeking the highest excellence in the fields of population biology, antibiotic resistance, respiratory infection, microbiota, metagenomics and HIV.

Search for publications

Only original articles, editorials, guidelines.

  • van Hal SJ, Willems RJL, Gouliouris T, Ballard SA, Coque TM, Hammerum AM, Hegstad K, Pinholt M, Howden BP, Malhotra-Kumar S, Werner G, Yanagihara K, Earl AM, Raven KE, Corander J, Bowden R, Enterococcal Study Group.

    The interplay between community and hospital Enterococcus faecium clones within health-care settings: a genomic analysis.

    The Lancet. Microbe . 3(2): .

    [doi:10.1016/S2666-5247(21)00236-6]

  • Gill CM, Aktaþ E, Alfouzan W, Bourassa L, Brink A, Burnham CD, Canton R, Carmeli Y, Falcone M, Kiffer C, Marchese A, Martinez O, Pournaras S, Satlin MJ, Seifert H, Thabit AK, Thomson KS, Villegas MV, Nicolau DP.

    Multicenter, Prospective Validation of a Phenotypic Algorithm to Guide Carbapenemase Testing in Carbapenem-Resistant Pseudomonas aeruginosa Using the ERACE-PA Global Surveillance Program

    Open forum infectious diseases . 9(2): . Number of citations: 3

    [doi:10.1093/ofid/ofab617]

  • Cantón R, Barberán J, Linares M, Molero JM, Rodríguez-González-Moro JM, Salavert M, González Del Castillo J.

    Decalogue for the selection of oral antibiotics for lower respiratory tract infections.

    REVISTA ESPANOLA DE QUIMIOTERAPIA . 35(1): 16-29. Number of citations: 1

    [doi:10.37201/req/172.2021]

  • Aranaz-Andrés JM, Chávez ACF, Laso AM, Abreu M, Núñez PM, Galán JC, Moreno RC.

    Analysis of the diagnostic accuracy of rapid antigenic tests for detection of SARS-CoV-2 in hospital outbreak situation

    EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES . 41(2): 1-8. Number of citations: 2

    [doi:10.1007/s10096-021-04346-8]

  • Caniego-Casas T, Martínez-García L, Alonso-Riaño M, Pizarro D, Carretero-Barrio I, Martínez-de-Castro N, Ruz-Caracuel I, de Pablo R, Saiz A, Royo RN, Santiago A, Rosas M, Rodríguez-Peralto JL, Pérez-Mies B, Galán JC, Palacios J.

    RNA SARS-CoV-2 Persistence in the Lung of Severe COVID-19 Patients: A Case Series of Autopsies.

    FRONTIERS IN MICROBIOLOGY . 13: 824967-824967. Number of citations: 4

    [doi:10.3389/fmicb.2022.824967]

  • Gato E, Anantharajah A, Arroyo MJ, Artacho MJ, Caballero JD, Candela A, Chudejová K, Constanso IP, Elías C, Fernández J, Jiménez J, Lumbreras P, Méndez G, Mulet X, Pérez-Palacios P, Rodríguez-Sánchez B, Cantón R, Hrabák J, Mancera L, Martínez-Martínez L, Oliver A, Pascual Á, Verroken A, Bou G, Oviaño M.

    Multicenter Performance Evaluation of MALDI-TOF MS for Rapid Detection of Carbapenemase Activity in Enterobacterales: The Future of Networking Data Analysis With Online Software

    FRONTIERS IN MICROBIOLOGY . 12: 789731-789731. Number of citations: 5

    [doi:10.3389/fmicb.2021.789731]

  • Rodríguez-Beltrán J, León-Sampedro R, Ramiro-Martínez P, de la Vega C, Baquero F, Levin BR, San Millán Á.

    Translational demand is not a major source of plasmid-associated fitness costs.

    PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES . 377(1842): 20200463-20200463. Number of citations: 4

    [doi:10.1098/rstb.2020.0463]

  • Santos-Lopez, Alfonso, Fritz, Melissa J., Lombardo, Jeffrey B., Burr, Ansen H. P., Heinrich, Victoria A., Marshall, Christopher W., Cooper, Vaughn S..

    Evolved resistance to a novel cationic peptide antibiotic requires high mutation supply

    EVOLUTION MEDICINE AND PUBLIC HEALTH . 10(1): 266-276. Number of citations: 1

    [doi:10.1093/emph/eoac022]

  • Pintado V, Ruiz-Garbajosa P, Escudero R, Gioia F, Herrera S, Vizcarra P, Fortún J, Cobo J, Martín-Dávila P, Morosini MI, Cantón R, Moreno S.

    Carbapenemase-producing Enterobacterales infections in COVID-19 patients

    INFECTIOUS DISEASES . 54(1): 36-45. Number of citations: 8

    [doi:10.1080/23744235.2021.1963471]

  • Lopez-Cauce, Beatriz, Puerto, Marta, Garcia, Juan Jose, Ponce-Alonso, Manuel, Becerra-Aparicio, Federico, del Campo, Rosa, Peligros, Isabel, Fernandez-Acenero, Maria J, Gomez-Navarro, Yesica, Lara, Jose M, Miranda-Bautista, Jose, Marin-Jimenez, Ignacio, Banares, Rafael, Menchen, Luis.

    Akkermansia deficiency and mucin depletion are implicated in intestinal barrier dysfunction as earlier event in the development of inflammation in interleukin-10-deficient mice.

    FRONTIERS IN MICROBIOLOGY . 13: 1083884-1083884. Number of citations: 1

    [doi:10.3389/fmicb.2022.1083884]

  • Salazar N, Ponce-Alonso M, Garriga M, Sánchez-Carrillo S, Hernández-Barranco AM, Redruello B, Fernández M, Botella-Carretero JI, Vega-Piñero B, Galeano J, Zamora J, Ferrer M, de Los Reyes-Gavilán CG, Del Campo R.

    Fecal Metabolome and Bacterial Composition in Severe Obesity: Impact of Diet and Bariatric Surgery.

    Gut Microbes . 14(1): 2106102-2106102. Number of citations: 2

    [doi:10.1080/19490976.2022.2106102]

  • Brem J, Panduwawala T, Hansen JU, Hewitt J, Liepins E, Donets P, Espina L, Farley AJM, Shubin K, Campillos GG, Kiuru P, Shishodia S, Krahn D, Lesniak RK, Schmidt Adrian J, Calvopiña K, Turrientes MC, Kavanagh ME, Lubriks D, Hinchliffe P, Langley GW, Aboklaish AF, Eneroth A, Backlund M, Baran AG, Nielsen EI, Speake M, Kuka J, Robinson J, Grinberga S, Robinson L, McDonough MA, Rydzik AM, Leissing TM, Jimenez-Castellanos JC, Avison MB, Da Silva Pinto S, Pannifer AD, Martjuga M, Widlake E, Priede M, Hopkins Navratilova I, Gniadkowski M, Belfrage AK, Brandt P, Yli-Kauhaluoma J, Bacque E, Page MGP, Björkling F, Tyrrell JM, Spencer J, Lang PA, Baranczewski P, Cantón R, McElroy SP, Jones PS, Baquero F, Suna E, Morrison A, Walsh TR, Schofield CJ.

    Imitation of beta-lactam binding enables broad-spectrum metallo-beta-lactamase inhibitors

    NATURE CHEMISTRY . 14(1): 15. Number of citations: 9

    [doi:10.1038/s41557-021-00831-x]

  • Cuartas R, Coque TM, de la Cruz F, Garcillán-Barcia MP.

    PLASmid TAXonomic PCR (PlasTax-PCR), a Multiplex Relaxase MOB Typing to Assort Plasmids into Taxonomic Units.

    Methods in molecular biology (Clifton, N.J.) . 2392: 127-142.

    [doi:10.1007/978-1-0716-1799-1_10]

  • García-Fernández S, Simner PJ, Thomson G, Faron M, Bosboom R, van Griethuijsen A, García-Castillo M, Harris R, Ledeboer NA, Cantón R, Thomson KS.

    Rapid identification from rectal swabs of the clinically most relevant carbapenemase genes from gram-negative bacteria using the BD MAX Check-Points CPO Assay.

    DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE . 102(1): 115554-115554. Number of citations: 1

    [doi:10.1016/j.diagmicrobio.2021.115554]

  • García-Caballero A, de Dios Caballero J, Maruri A, Serrano-Tomás MI, del Campo R, Morosini MI, Cantón R.

    Evaluation of different phenotypic methods to detect methicillin resistance in Staphylococcus aureus isolates recovered from cystic fibrosis patients.

    DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE . 102(1): 115559-115559. Number of citations: 1

    [doi:10.1016/j.diagmicrobio.2021.115559]

  • Otheo E, Rodríguez M, Moraleda C, Domínguez-Rodríguez S, Martín MD, Herreros ML, Vázquez C, Folgueira MD, Pérez-Rivilla A, Jensen J, López A, Berzosa A, Sanz de Santaeufemia FJ, Jiménez AB, Sainz T, Llorente M, Santos M, Garrote E, Muñoz C, Sánchez P, Illán M, Coca A, Barrios A, Pacheco M, Arquero C, Gutiérrez L, Epalza C, Rojo P, Serna-Pascual M, Mota I, Moreno S, Galán JC, Tagarro A.

    Viruses and Mycoplasma pneumoniae are the main etiological agents of community-acquired pneumonia in hospitalized pediatric patients in Spain

    PEDIATRIC PULMONOLOGY . 57(1): 253-263. Number of citations: 3

    [doi:10.1002/ppul.25721]

  • Tagarro A, Moraledas C, Domínguez-Rodríguez S, Rodríguez M, Martín MD, Luisa Herreros M, Jensen J, López A, Carlos Galán J, Otheo E.

    A Tool to Distinguish Viral From Bacterial Pneumonia

    PEDIATRIC INFECTIOUS DISEASE JOURNAL . 41(1): 31-36. Number of citations: 3

    [doi:10.1097/INF.0000000000003340]

  • Rodríguez I, Figueiredo AS, Sousa M, Aracil-Gisbert S, Fernández-de-Bobadilla MD, Lanza VF, Rodríguez C, Zamora J, Loza E, Mingo P, Brooks CJ, Cantón R, Baquero F, Coque TM.

    A 21-Year Survey of Escherichia coli from Bloodstream Infections (BSI) in a Tertiary Hospital Reveals How Community-Hospital Dynamics of B2 Phylogroup Clones Influence Local BSI Rates.

    mSphere . 6(6): . Number of citations: 4

    [doi:10.1128/msphere.00868-21]