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Lipid metabolism

The Clinical and Applied Lipidomics for Metabolism Research Group investigates the role of lipids, particularly ceramides and cholesterol, in cardiometabolic, liver, and neurodegenerative diseases. Its activities integrate basic, translational, and clinical research, with a strong focus on the identification of biomarkers and the development of advanced lipidomics and metabolomics methodologies using mass spectrometry.

The group is supported by competitive national funding, has a strong international scientific publication record, and is currently developing a patent. In addition, it contributes to the Lipidomic and Proteomic Characterization Unit (UCA-CLP) and maintains strategic collaborations at both the national and international levels.

Search for publications

Only original articles, editorials, guidelines.

  • Gaudioso A, Garcia-Rozas P, Casarejos MJ, Pastor O, Rodriguez-Navarro JA.

    Lipidomic Alterations in the Mitochondria of Aged Parkin Null Mice Relevant to Autophagy.

    Frontiers in Neuroscience . 13: 329-329. Number of citations: 32

    [doi:10.3389/fnins.2019.00329]

  • Calderón B, Huerta L, Casado ME, González-Casbas JM, Botella-Carretero JI, Martín-Hidalgo A.

    Morbid obesity-related changes in the expression of lipid receptors, transporters, and HSL in human sperm.

    JOURNAL OF ASSISTED REPRODUCTION AND GENETICS . 36(4): 777-786. Number of citations: 16

    [doi:10.1007/s10815-019-01406-z]

  • García L, Fernández M, Bengoa N, Pintor R, Arrieta F.

    Nutrition parenteral: Albumin versus total proteins in the assessment of plasma calcium to adjust parenteral nutrition: A series of cases.

    Endocrinologia, diabetes y nutricion . 66(4): 272-274. Number of citations: 2

    [doi:10.1016/j.endinu.2018.11.006]

  • González-Ramos S, Paz-García M, Rius C, Del Monte-Monge A, Rodríguez C, Fernández-García V, Andrés V, Martínez-González J, Lasunción MA, Martín-Sanz P, Soehnlein O, Boscá L.

    Endothelial NOD1 directs myeloid cell recruitment in atherosclerosis through VCAM-1.

    FASEB JOURNAL . 33(3): 3912-3921. Number of citations: 33

    [doi:10.1096/fj.201801231RR]

  • Ramos-Molina B, Castellano-Castillo D, Pastor O, Ocaña-Wilhelmi L, Fernández-García D, Romero-Gómez M, Cardona F, Tinahones FJ.

    A Pilot Study of Serum Sphingomyelin Dynamics in Subjects with Severe Obesity and Non-alcoholic Steatohepatitis after Sleeve Gastrectomy.

    OBESITY SURGERY . 29(3): 983-989. Number of citations: 10

    [doi:10.1007/s11695-018-3612-2]

  • Santacruz E, Mateo-Lobo R, Riveiro J, Nattero L, Vega-Piñero B, Lomba G, Sabido R, Carabaña F, Arrieta FJ, Botella-Carretero JI.

    Infectious complications in home parenteral nutrition: A long-term study with peripherally inserted central catheters, tunneled catheters, and ports.

    NUTRITION . 58: 89-93. Number of citations: 27

    [doi:10.1016/j.nut.2018.06.016]

  • Sánchez-Ruano L, de la Hoz B, Martínez-Botas J.

    Clinical utility of microarray B-cell epitope mapping in food allergies: A systematic review.

    PEDIATRIC ALLERGY AND IMMUNOLOGY . 31(2): 175-185. Number of citations: 17

    [doi:10.1111/pai.13141]

  • Pastor Ó, Guzmán-Lafuente P, Serna J, Muñoz-Hernández M, López Neyra A, García-Rozas P, García-Seisdedos D, Alcázar A, Lasunción MA, Busto R, Lamas Ferreiro A.

    A comprehensive evaluation of omega-3 fatty acid supplementation in cystic fibrosis patients using lipidomics.

    JOURNAL OF NUTRITIONAL BIOCHEMISTRY . 63: 197-205. Number of citations: 16

    [doi:10.1016/j.jnutbio.2018.09.026]

  • Ramos-Molina B, Castellano-Castillo D, Alcaide-Torres J, Pastor Ó, de Luna Díaz R, Salas-Salvadó J, López-Moreno J, Fernández-García JC, Macías-González M, Cardona F, Tinahones FJ.

    Differential effects of restrictive and malabsorptive bariatric surgery procedures on the serum lipidome in obese subjects.

    Journal of Clinical Lipidology . 12(6): 1502-1512. Number of citations: 22

    [doi:10.1016/j.jacl.2018.07.006]

  • de Dios O, Navarro P, Ortega-Senovilla H, Herrero L, Gavela-Pérez T, Soriano-Guillen L, Lasunción MA, Garcés C.

    Plasma Retinol Levels and High-Sensitivity C-Reactive Protein in Prepubertal Children.

    Nutrients . 10(9): . Number of citations: 9

    [doi:10.3390/nu10091257]

  • Busto R, Serna J, Perianes-Cachero A, Quintana-Portillo R, García-Seisdedos D, Canfrán-Duque A, Paino CL, Lerma M, Casado ME, Martín-Hidalgo A, Arilla-Ferreiro E, Lasunción MA, Pastor Ó.

    Ellagic acid protects from myelin-associated sphingolipid loss in experimental autoimmune encephalomyelitis.

    BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS . 1863(9): 958-967. Number of citations: 44

    [doi:10.1016/j.bbalip.2018.05.009]

  • Arrieta F, Ojeda S, Rueda Á, Stanescu S, Belanger-Quintana A, Martínez-Pardo M.

    Déficit de glicerol kinasa en el adulto: hipertrigliceridemia resistente a tratamiento dietético y farmacológico.

    Nutricion Hospitalaria . 35(4): 993-995.

    [doi:10.20960/nh.1921]

  • Gómez-Martin JM, Balsa JA, Aracil E, Cuadrado-Ayuso M, Rosillo M, De la Peña G, Lasunción MA, Escobar-Morreale HF, Botella-Carretero JI.

    Beneficial changes on plasma apolipoproteins A and B, high density lipoproteins and oxidized low density lipoproteins in obese women after bariatric surgery: comparison between gastric bypass and sleeve gastrectomy.

    Lipids in Health and Disease . 17(1): 145-145. Number of citations: 20

    [doi:10.1186/s12944-018-0794-5]

  • Arrieta F, Iglesias P, Pedro-Botet J, Becerra A, Ortega E, Obaya JC, Nubiola A, Maldonado GF, Campos MDM, Petrecca R, Pardo JL, Sánchez-Margalet V, Alemán JJ, Navarro J, Duran S, Tébar FJ, Aguilar M, Escobar F.

    Diabetes mellitus and cardiovascular risk: Update of the recommendations of the Diabetes and Cardiovascular Disease working group of the Spanish Diabetes Society (SED, 2018).

    Clinica e Investigacion en Arteriosclerosis . 30(3): 137-153. Number of citations: 10

    [doi:10.1016/j.arteri.2018.03.002]

  • Crespo MC, Tomé-Carneiro J, Gómez-Coronado D, Burgos-Ramos E, García-Serrano A, Martín-Hernández R, Baliyan S, Fontecha J, Venero C, Dávalos A, Visioli F.

    Modulation of miRNA expression in aged rat hippocampus by buttermilk and krill oil.

    Scientific Reports . 8(1): 3993-3993. Number of citations: 23

    [doi:10.1038/s41598-018-22148-5]

  • Calderón B, Hevia V, Vega-Piñero B, Martín-Hidalgo A, Mendez-Del Sol H, Escobar-Morreale HF, Botella-Carretero JI.

    Serum Retinol, Folic Acid, and Copper Are Associated With Sperm Abnormalities in Men With Obesity.

    JOURNAL OF THE AMERICAN COLLEGE OF NUTRITION . 37(3): 194-200. Number of citations: 7

    [doi:10.1080/07315724.2017.1387877]

  • Spreafico F, Sales RC, Gil-Zamorano J, Medeiros PDC, Latasa MJ, Lima MR, de Souza SAL, Martin-Hernández R, Gómez-Coronado D, Iglesias-Gutierrez E, Mantilla-Escalante DC, das Graças Tavares do Carmo M, Dávalos A.

    Dietary supplementation with hybrid palm oil alters liver function in the common Marmoset.

    Scientific Reports . 8(1): 2765-2765. Number of citations: 13

    [doi:10.1038/s41598-018-21151-0]

  • del Castillo, Francisco J., Munoz, Gloria, Garcia-Seisdedos, David, Sanchez-Herranz, Antonio, Morado, Marta, Valles, Ana, Piris, Miguel, Martin-Moro, Fernando, Sanz-Ruperez, Alejandro, Lopez-Jimenez, Javier, Villarrubia, Jesus.

    Fast genetic diagnosis of lysosomal disorders by means of a novel NGS-based resequencing gene panel

    MOLECULAR GENETICS AND METABOLISM . 123(2): 38-38. Number of citations: 1

    [doi:10.1016/j.ymgme.2017.12.079]