Lipid metabolism
The Clinical and Applied Lipidomics for Metabolism Research Group investigates the role of lipids, particularly ceramides and cholesterol, in cardiometabolic, liver, and neurodegenerative diseases. Its activities integrate basic, translational, and clinical research, with a strong focus on the identification of biomarkers and the development of advanced lipidomics and metabolomics methodologies using mass spectrometry.
The group is supported by competitive national funding, has a strong international scientific publication record, and is currently developing a patent. In addition, it contributes to the Lipidomic and Proteomic Characterization Unit (UCA-CLP) and maintains strategic collaborations at both the national and international levels.
Search for publications
Only original articles, editorials, guidelines.
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Gómez-Coronado D, Rodríguez-Jiménez C, Villar P, Fernández-Suárez ME, Eble JA, de la Peña G, Martínez-Botas J, Acebes-Huerta A, Prieto-Cazorla P, Villa-Fajardo M, Lasunción MA, Rodríguez-Nóvoa S, Gutiérrez L.
A novel ABCA1 variant associated with impaired platelet production contributing to thrombocytopenia in a family with Tangier disease.
Journal of Clinical Lipidology . 20(2): 411-427.
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Abad Cobo M, González Díaz C, Martínez-Botas J, Diaz-Montalvo L, Gamboa Setien P.
Drug-Induced Enterocolitis Syndrome (DIES): A Case Report and Diagnostic Considerations
JOURNAL OF INVESTIGATIONAL ALLERGOLOGY AND CLINICAL IMMUNOLOGY . 35(6): 479-480.
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Del Saz-Lara A, López de Las Hazas MC, Tomé-Carneiro J, Mazarío-Gárgoles C, Gil-Zamorano J, Balaguer L, Del Pozo-Acebo L, González-Sarrías A, Ávila-Gálvez MÁ, Espín JC, Gómez-Coronado D, Visioli F, Dávalos A.
Milk and cheesemaking whey as a sustainable source of extracellular vesicles: Exploring large-scale isolation methods with industrial and potential therapeutic applications.
PHARMACOLOGICAL RESEARCH . 220: 107925-107925. Number of citations: 7
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de Nicolas-Ruanes B, Fernandez-Lozano C, Gutierrez-Canales P, Ballester-Martinez A, Rodriguez-Otero N, Martinez-Botas J, De La Hoz Caballer B, Andres-Martin A, Solano-Solares E, Gomez-Salazar Lopez-Silanes ME, Diaz-Montalvo LG, Arrebola DM, Stewart-Delcid VL, Garcia-Mouronte E, Azcarraga-Llobet C, Berna-Rico E, Ortega-Sanchez S, Fernandez-Guarino M.
Lymphocyte Transformation Tests and Patch Tests to Identify Drugs Potentially Associated With Bullous Pemphigoid Development
INTERNATIONAL JOURNAL OF DERMATOLOGY . 64(9): 1636-1643. Number of citations: 1
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Torrecilla-Parra M, Pardo-Marqués V, Fuentes-Fayos AC, G-García ME, Fernández-de Frutos M, López-Aceituno JL, Puigdueta C, Zamora C, Pérez-García A, Aranda JF, Busto R, Gahete MD, Luque RM, Ramírez CM.
MiR-7 inhibits progression of glioblastoma by impairing autophagy resolution, energy metabolism and ECM remodeling
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH . 44(1): 237-237. Number of citations: 6
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Gajate Martín L, de la Hoz I, Martín M, Fernández C, Martín Grande A, Parise D, Villahoz J, Gómez M, Espiño M, Pastor O, Rodríguez Gandía MÁ, Nuño J.
A randomized trial of ascorbic acid for the prevention of post-reperfusion syndrome during liver transplantation
Hepatology Communications . 9(8): . Number of citations: 3
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Chavarría-Cubel I, Molina YL, Babiy B, Lerma M, Martínez-Botas J, de la Peña G, Vallejo MT, Villanueva-Blanco T, Gómez-Coronado D, Alcazar A, Lasunción MA, Pastor Ó, Busto R.
The synthetic TRPML1 agonist ML-SA1 mitigates intracellular lipid accumulation induced by antipsychotics in vitro by stimulating release of extracellular microvesicles
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS . 1870(4): 159611-159611.
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Fernández-Lozano C, Olmos-Piñero S, Sánchez-Ruano L, Terrados S, Diéguez MDC, Fernández-Rivas M, Vlaicu C, Cerecedo I, Gonzalo-Fernandez A, de la Hoz B, Martínez-Botas J.
Predicting Tolerance to Cow's Milk Allergy in Children Using IgE and IgG4 Peptide Binding Profiles
Cells . 14(5): . Number of citations: 2
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Cardenas Herrero A, Fernandez-Lozano C, Ramirez-Mateo E, Alcalá-Rodriguez MG, Solano-Solares E, Blanchard-Rodriguez MJ, Pueyo-Lopez C, de la Hoz B, Martínez-Botas J.
Two Immediate Hypersensitivity Reactions to Isatuximab Confirmed by the Complement Activation Test and Treated With Successful Rapid Desensitization
JOURNAL OF INVESTIGATIONAL ALLERGOLOGY AND CLINICAL IMMUNOLOGY . 35(5): 392-394.
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Carrasco-Gomez, Luis, Lecumberri, Alba, Renilla-Arroyo, Jose Maria, de la Hoz-Caballer, Belen, Diaz-Montalvo, Laura, Martinez-Botas, Javier, Barra-Castro, Alicia, Fernandez-Guarino, Montserrat.
Diagnostic Characterization of Symmetrical Drug-Related Intertriginous and Flexural Exanthema (SDRIFE): A Retrospective Study From a Tertiary Care Hospital
Dermatologic Therapy . 2025(1): .
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Cerecedo I, de la Hoz B, Infante S, Freundt Serpa NP, Vaquero Rey A, Carrón Herrero A, Vázquez Cortés S, Garban Camero A, Redondo Vegas E, Gonzalo-Fernández A, Serrano García I, López-Picado A, Fernández-Rivas M, MARTÍNEZ-BOTAS MATEO, JAVIER.
Safety, Tolerability, and Feasibility of the Milk Ladder for Reintroduction of Cow's Milk in Infants With IgE-Mediated Cow's Milk Allergy.
JOURNAL OF INVESTIGATIONAL ALLERGOLOGY AND CLINICAL IMMUNOLOGY . 34(6): 414-416. Number of citations: 2
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Díez-Ricote L, Cuadrado-Soto E, Pastor-Fernández A, de la Peña G, Martinez-Botas J, Castañer O, Martínez-González MA, Salas-Salvado J, Fernández-Marcos PJ, Gómez-Coronado D, Ordovas J, Daimiel L.
Effect of a Multifactorial Weight Loss Intervention on HDL Cholesterol Efflux Capacity and Immunosenescence: A Randomized Controlled Trial.
Journal of the American Nutrition Association . : 1-14. Number of citations: 4
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Borràs C, Canyelles M, Girona J, Ibarretxe D, Santos D, Revilla G, Llorente-Cortes V, Rotllan N, Kovanen PT, Jauhiainen M, Lee-Rueckert M, Masana L, Arrieta F, Martínez-Botas J, Gómez-Coronado D, Ribalta J, Tondo M, Blanco-Vaca F, Escolà-Gil JC.
PCSK9 Antibodies Treatment Specifically Enhances the Macrophage-specific Reverse Cholesterol Transport Pathway in Heterozygous Familial Hypercholesterolemia.
JACC-Basic to Translational Science . 9(10): 1195-1210.
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Fernández-Tussy P, Cardelo MP, Zhang H, Sun J, Price NL, Boutagy NE, Goedeke L, Cadena-Sandoval M, Xirouchaki CE, Brown W, Yang X, Pastor-Rojo O, Haeusler RA, Bennett AM, Tiganis T, Suárez Y, Fernández-Hernando C.
miR-33 deletion in hepatocytes attenuates MASLD-MASH-HCC progression.
JCI Insight . 9(19): . Number of citations: 25
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López de Las Hazas MDC, Tomé-Carneiro J, Balaguer L, de la Peña G, Chapado LA, Alonso-Bernáldez M, Del Saz-Lara A, Gil-Zamorano J, Burgos-Ramos E, Rodríguez-Pérez M, Gómez-Coronado D, Dávalos A.
Dietary plant microRNAs as potential regulators of cellular cholesterol efflux.
Clinica e Investigacion en Arteriosclerosis . 36(6): 315-324. Number of citations: 7
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Fernández-Lozano C, Rita CG, Barra-Castro A, De La Hoz Caballer B, Roldán E, Pueyo López C, Martinez-Botas J, Berges-Gimeno MP.
Specific IgE and Basophil Activation Test by Microarray: A Promising Tool for Diagnosis of Platinum Compound Hypersensitivity Reactions.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES . 25(7): . Number of citations: 3
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Montero-Vega MT, Matilla J, Bazán E, Reimers D, De Andrés-Martín A, Gonzalo-Gobernado R, Correa C, Urbano F, Gómez-Coronado D.
Fluvastatin Converts Human Macrophages into Foam Cells with Increased Inflammatory Response to Inactivated Mycobacterium tuberculosis H37Ra.
Cells . 13(6): . Number of citations: 4
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Rodríguez-Otero N, Fernández-Lozano C, Vicente-Santamaría S, Díaz-Montalvo L, Menéndez-Conde C, Sola-Martínez FJ.
Rapid drug desensitization protocol in delayed hypersensitivity reactions to CFTR modulator drugs: When everyday counts.
JOURNAL OF INVESTIGATIONAL ALLERGOLOGY AND CLINICAL IMMUNOLOGY . 34(5): 0-0. Number of citations: 1