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Lipid metabolism

The Clinical and Applied Lipidomics for Metabolism Research Group investigates the role of lipids, particularly ceramides and cholesterol, in cardiometabolic, liver, and neurodegenerative diseases. Its activities integrate basic, translational, and clinical research, with a strong focus on the identification of biomarkers and the development of advanced lipidomics and metabolomics methodologies using mass spectrometry.

The group is supported by competitive national funding, has a strong international scientific publication record, and is currently developing a patent. In addition, it contributes to the Lipidomic and Proteomic Characterization Unit (UCA-CLP) and maintains strategic collaborations at both the national and international levels.

Search for publications

Only original articles, editorials, guidelines.

  • Canfrán-Duque A, Rotllan N, Zhang X, Andrés-Blasco I, Thompson BM, Sun J, Price NL, Fernández-Fuertes M, Fowler JW, Gómez-Coronado D, Sessa WC, Giannarelli C, Schneider RJ, Tellides G, McDonald JG, Fernández-Hernando C, Suárez Y.

    Macrophage-Derived 25-Hydroxycholesterol Promotes Vascular Inflammation, Atherogenesis, and Lesion Remodeling

    CIRCULATION . 147(5): 388-408. Number of citations: 107

    [doi:10.1161/CIRCULATIONAHA.122.059062]

  • Martínez-Botas J, Fernández-Lozano C, Vaquero-Rey A, de la Hoz B.

    IgE and IgG4 Epitope Mapping of Food Allergens with a Peptide Microarray Immunoassay.

    Methods in molecular biology (Clifton, N.J.) . 2578: 219-236.

    [doi:10.1007/978-1-0716-2732-7_16]

  • Aranda JF, Pérez-García A, Torrecilla-Parra M, Fernández-de Frutos M, Martín-Martín Y, Mateos-Gómez PA, Pardo-Marqués V, Busto R, Ramírez CM.

    Role of miR-199a-5p in the post-transcriptional regulation of ABCA1 in response to hypoxia in peritoneal macrophages.

    Frontiers in Cardiovascular Medicine . 9: 994080-994080. Number of citations: 3

    [doi:10.3389/fcvm.2022.994080]

  • Del Pozo-Acebo L, López de Las Hazas MC, Tomé-Carneiro J, Del Saz-Lara A, Gil-Zamorano J, Balaguer L, Chapado LA, Busto R, Visioli F, Dávalos A.

    Therapeutic potential of broccoli-derived extracellular vesicles as nanocarriers of exogenous miRNAs

    PHARMACOLOGICAL RESEARCH . 185: 106472-106472. Number of citations: 112

    [doi:10.1016/j.phrs.2022.106472]

  • Luque Calvo C, Mataix Sanjuan ÁL, Candela Toha Á, Martínez Castro N, Pintor Recuenco MR, Calleja López JL, Botella-Carretero JI, Arrieta Blanco F.

    Impact of COVID-19 on Short- and Medium-Term Prescription of Enteral Nutrition in the General Population vs. Older People in the Community of Madrid, Spain

    Nutrients . 14(19): .

    [doi:10.3390/nu14193892]

  • Martínez MA, Úbeda A, Martínez-Botas J, Trillo MÁ.

    Field exposure to 50 Hz significantly affects wild-type and unfolded p53 expression in NB69 neuroblastoma cells

    Oncology Letters . 24(3): 295-295. Number of citations: 4

    [doi:10.3892/ol.2022.13415]

  • Martín-Martín Y, Pérez-García A, Torrecilla-Parra M, Fernández-de Frutos M, Pardo-Marqués V, Casarejos MJ, Busto R, Ramírez CM.

    New Insights on the Regulation of the Insulin-Degrading Enzyme: Role of microRNAs and RBPs.

    Cells . 11(16): . Number of citations: 10

    [doi:10.3390/cells11162538]

  • Stanescu S, Belanger-Quintana A, Fernández-Felix BM, Ruiz-Sala P, Alcaide P, Arrieta F, Martínez-Pardo M.

    Plasma CoQ10 Status in Patients with Propionic Acidaemia and Possible Benefit of Treatment with Ubiquinol.

    Antioxidants . 11(8): . Number of citations: 4

    [doi:10.3390/antiox11081588]

  • Fernández-García V, González-Ramos S, Avendaño-Ortiz J, Martín-Sanz P, Gómez-Coronado D, Delgado C, Castrillo A, Boscá L.

    High-fat diet activates splenic NOD1 and enhances neutrophil recruitment and neutrophil extracellular traps release in the spleen of ApoE-deficient mice

    CELLULAR AND MOLECULAR LIFE SCIENCES . 79(8): 396-396. Number of citations: 14

    [doi:10.1007/s00018-022-04415-x]

  • Sánchez-Ruano L, Fernández-Lozano C, Ferrer M, Gómez F, de la Hoz B, Martínez-Botas J, Goikoetxea MJ.

    Differences in Linear Epitopes of Ara h 9 Recognition in Peanut Allergic and Tolerant, Peach Allergic Patients.

    Frontiers in Allergy . 3: 896617-896617. Number of citations: 5

    [doi:10.3389/falgy.2022.896617]

  • Bélanger-Quintana A, Arrieta Blanco F, Barrio-Carreras D, Bergua Martínez A, Cañedo Villarroya E, García-Silva MT, Lama More R, Martín-Hernández E, López AM, Morales-Conejo M, Pedrón-Giner C, Quijada-Fraile P, Stanescu S, Casanova MM.

    Recommendations for the Diagnosis and Therapeutic Management of Hyperammonaemia in Paediatric and Adult Patients

    Nutrients . 14(13): . Number of citations: 23

    [doi:10.3390/nu14132755]

  • Stanescu S, Bravo-Alonso I, Belanger-Quintana A, Pérez B, Medina-Diaz M, Ruiz-Sala P, Flores NP, Buenache R, Arrieta F, Rodríguez-Pombo P.

    Mitochondrial bioenergetic is impaired in Monocarboxylate transporter 1 deficiency: a new clinical case and review of the literature.

    Orphanet Journal of Rare Diseases . 17(1): 243-243. Number of citations: 5

    [doi:10.1186/s13023-022-02389-4]

  • Molina YL, García-Seisdedos D, Babiy B, Lerma M, Martínez-Botas J, Casarejos MJ, Vallejo MT, Gómez-Coronado D, Lasunción MA, Pastor Ó, Busto R.

    Rottlerin Stimulates Exosome/Microvesicle Release Via the Increase of Ceramide Levels Mediated by Ampk in an In Vitro Model of Intracellular Lipid Accumulation.

    Biomedicines . 10(6): . Number of citations: 8

    [doi:10.3390/biomedicines10061316]

  • Stanescu S, Belanger-Quintana A, Fernandez-Felix BM, Ruiz-Sala P, Del Valle M, Garcia F, Arrieta F, Martinez-Pardo M.

    Interorgan amino acid interchange in propionic acidemia: the missing key to understanding its physiopathology.

    AMINO ACIDS . 54(5): 777-786. Number of citations: 13

    [doi:10.1007/s00726-022-03128-6]

  • Abuobeid R, Sánchez-Marco J, Felices MJ, Arnal C, Burillo JC, Lasheras R, Busto R, Lasunción MA, Rodríguez-Yoldi MJ, Martínez-Beamonte R, Osada J.

    Squalene through Its Post-Squalene Metabolites Is a Modulator of Hepatic Transcriptome in Rabbits

    INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES . 23(8): . Number of citations: 9

    [doi:10.3390/ijms23084172]

  • Carpio-Escalona LV, Fernández-Lozano C, Peracho L, Martínez-Alonso E, Rita CG, Martínez-Botas J, Alcázar A, De La Hoz Caballer B.

    Two new allergens in a watermelon (Citrullus lanatus) allergy episode.

    JOURNAL OF INVESTIGATIONAL ALLERGOLOGY AND CLINICAL IMMUNOLOGY . 33(1): 0-0. Number of citations: 2

    [doi:10.18176/jiaci.0804]

  • López de Las Hazas MC, Del Pozo-Acebo L, Hansen MS, Gil-Zamorano J, Mantilla-Escalante DC, Gómez-Coronado D, Marín F, Garcia-Ruiz A, Rasmussen JT, Dávalos A.

    Dietary bovine milk miRNAs transported in extracellular vesicles are partially stable during GI digestion, are bioavailable and reach target tissues but need a minimum dose to impact on gene expression

    EUROPEAN JOURNAL OF NUTRITION . 61(2): 1043-1056. Number of citations: 87

    [doi:10.1007/s00394-021-02720-y]

  • Carrón-Herrero A, Fernández-Lozano C, Botella-Carretero JI, Palomino-Quintanilla L, Martínez-Botas J, Solano-Solares E.

    Delayed Hypersensitivity Reaction to Iron Salts: From Diagnosis to Desensitization.

    JOURNAL OF INVESTIGATIONAL ALLERGOLOGY AND CLINICAL IMMUNOLOGY . 32(6): 496-498. Number of citations: 3

    [doi:10.18176/jiaci.0789]