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Lipid metabolism

The Clinical and Applied Lipidomics for Metabolism Research Group investigates the role of lipids, particularly ceramides and cholesterol, in cardiometabolic, liver, and neurodegenerative diseases. Its activities integrate basic, translational, and clinical research, with a strong focus on the identification of biomarkers and the development of advanced lipidomics and metabolomics methodologies using mass spectrometry.

The group is supported by competitive national funding, has a strong international scientific publication record, and is currently developing a patent. In addition, it contributes to the Lipidomic and Proteomic Characterization Unit (UCA-CLP) and maintains strategic collaborations at both the national and international levels.

Search for publications

Only original articles, editorials, guidelines.

  • Ronald J, Rajagopalan R, Cerrato F, Nord AS, Hatsukami T, Kohler T, Marcovina S, Heagerty P, Jarvik GP.

    Genetic Variation in LPAL2, LPA, and PLG Predicts Plasma Lipoprotein(a) Level and Carotid Artery Disease Risk

    STROKE . 42(1): 2-9. Number of citations: 39

    [doi:10.1161/STROKEAHA.110.591230]

  • Rodríguez-Acebes S, Palacios N, Botella-Carretero JI, Olea N, Crespo L, Peromingo R, Gómez-Coronado D, Lasunción MA, Vázquez C, Martínez-Botas J.

    Gene expression profiling of subcutaneous adipose tissue in morbid obesity using a focused microarray: Distinct expression of cell-cycle- and differentiation-related genes

    BMC Medical Genomics . 3: 61-61. Number of citations: 41

    [doi:10.1186/1755-8794-3-61]

  • Guardiola M, Ribalta J, Gómez-Coronado D, Lasunción MA, de Oya M, Garcés C.

    The apolipoprotein A5 (APOA5) gene predisposes Caucasian children to elevated triglycerides and vitamin E (Four Provinces Study)

    ATHEROSCLEROSIS . 212(2): 543-547. Number of citations: 19

    [doi:10.1016/j.atherosclerosis.2010.07.004]

  • Albillos A, Nieto M, Ubeda M, Muñoz L, Fraile B, Reyes E, Lledó L, Blanco I, Pastor O, Salas C, Lario M, Monserrat J, Bataller R, Alvarez-Mon M.

    The biological response modifier AM3 attenuates the inflammatory cell response and hepatic fibrosis in rats with biliary cirrhosis

    GUT . 59(7): 943-952. Number of citations: 11

    [doi:10.1136/gut.2008.168831]

  • Sánchez-Wandelmer J, Dávalos A, de la Peña G, Cano S, Giera M, Canfrán-Duque A, Bracher F, Martín-Hidalgo A, Fernández-Hernando C, Lasunción MA, Busto R.

    HALOPERIDOL DISRUPTS LIPID RAFTS AND IMPAIRS INSULIN SIGNALING IN SH-SY5Y CELLS

    NEUROSCIENCE . 167(1): 143-153. Number of citations: 46

    [doi:10.1016/j.neuroscience.2010.01.051]

  • Cuevas EP, Escribano O, Monserrat J, Martínez-Botas J, Sánchez MG, Chiloeches A, Hernández-Breijo B, Sánchez-Alonso V, Román ID, Fernández-Moreno MD, Guijarro LG.

    RNAi-Mediated Silencing of Insulin Receptor Substrate-4 Enhances Actinomycin D- and Tumor Necrosis Factor-alpha-Induced Cell Death in Hepatocarcinoma Cancer Cell Lines

    JOURNAL OF CELLULAR BIOCHEMISTRY . 108(6): 1292-1301. Number of citations: 21

    [doi:10.1002/jcb.22359]

  • Mütze U, Gleich F, Garbade SF, Plisson C, Aldámiz-Echevarría L, Arrieta F, Ballhausen D, Zielonka M, Petkovic Ramadža D, Baumgartner MR, Cano A, García Jiménez MC, Dionisi-Vici C, Ješina P, Blom HJ, Couce ML, Meavilla Olivas S, Mention K, Mochel F, Morris AAM, Mundy H, Redonnet-Vernhet I, Santra S, Schiff M, Servais A, Vitoria I, Huemer M, Kožich V, Kölker S.

    Postauthorization safety study of betaine anhydrous.

    JOURNAL OF INHERITED METABOLIC DISEASE . : . Number of citations: 9

    [doi:10.1002/jimd.12499]

  • Cevallos K, Abad JL, Babiy B, Sacristán López S, Hidalgo-Llorente A, Senra Y, Busto R, Martínez-Botas J, Abad-Montero D, Bujons J, Fábrias G, Pastor Ó.

    Synthesis and Biological Evaluation of a New Dihydroceramide Desaturase Inhibitor for the Treatment of MASLD.

    JOURNAL OF MEDICINAL CHEMISTRY . : .

    [doi:10.1021/acs.jmedchem.5c03686]