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Neurodegenerative Diseases: therapy development

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  • Kurz A, Double KL, Lastres-Becker I, Tozzi A, Tantucci M, Bockhart V, Bonin M, García-Arencibia M, Nuber S, Schlaudraff F, Liss B, Fernández-Ruiz J, Gerlach M, Wüllner U, Lüddens H, Calabresi P, Auburger G, Gispert S.

    A53T-Alpha-Synuclein Overexpression Impairs Dopamine Signaling and Striatal Synaptic Plasticity in Old Mice

    Plos One . 5(7): . Number of citations: 87

    [doi:10.1371/journal.pone.0011464]

  • Fernández-Ruiz J, Hernández M, Ramos JA.

    Cannabinoid-Dopamine Interaction in the Pathophysiology and Treatment of CNS Disorders

    CNS NEUROSCIENCE & THERAPEUTICS . 16(3): 72-91. Number of citations: 115

    [doi:10.1111/j.1755-5949.2010.00144.x]

  • Sagar DR, Jhaveri MD, Richardson D, Gray RA, de Lago E, Fernández-Ruiz J, Barrett DA, Kendall DA, Chapman V.

    Endocannabinoid regulation of spinal nociceptive processing in a model of neuropathic pain

    EUROPEAN JOURNAL OF NEUROSCIENCE . 31(8): 1414-1422. Number of citations: 23

    [doi:10.1111/j.1460-9568.2010.07162.x]

  • Fernández-Ruiz J, García C, Sagredo O, Gómez-Ruiz M, de Lago E.

    The endocannabinoid system as a target for the treatment of neuronal damage

    EXPERT OPINION ON THERAPEUTIC TARGETS . 14(4): 387-404. Number of citations: 67

    [doi:10.1517/14728221003709792]

  • Mena MÁ, Perucho J, Rubio I, de Yébenes JG.

    Studies in Animal Models of the Effects of Anesthetics on Behavior, Biochemistry, and Neuronal Cell Death

    JOURNAL OF ALZHEIMERS DISEASE . 22(3): 43-48. Number of citations: 15

    [doi:10.3233/JAD-2010-100822]

  • Perucho J, Rubio I, Casarejos MJ, Gomez A, Rodriguez-Navarro JA, Solano RM, De Yébenes JG, Mena MA.

    Anesthesia with Isoflurane Increases Amyloid Pathology in Mice Models of Alzheimer's Disease

    JOURNAL OF ALZHEIMERS DISEASE . 19(4): 1245-1257. Number of citations: 66

    [doi:10.3233/JAD-2010-1318]

  • Perucho J, Casarejos MJ, Rubio I, Rodriguez-Navarro JA, Gómez A, Ampuero I, Rodal I, Solano RM, Carro E, García de Yébenes J, Mena MA.

    The effects of parkin suppression on the behaviour, amyloid processing, and cell survival in APP mutant transgenic mice

    EXPERIMENTAL NEUROLOGY . 221(1): 54-67. Number of citations: 15

    [doi:10.1016/j.expneurol.2009.09.029]

  • de Lago E, Gómez-Ruiz M, Moreno-Martet M, Fernández-Ruiz J.

    Cannabinoids, multiple sclerosis and neuroprotection.

    EXPERT REVIEW OF CLINICAL PHARMACOLOGY . 2(6): 645-660.

    [doi:10.1586/ecp.09.42]

  • Palazuelos J, Aguado T, Pazos MR, Julien B, Carrasco C, Resel E, Sagredo O, Benito C, Romero J, Azcoitia I, Fernández-Ruiz J, Guzmán M, Galve-Roperh I.

    Microglial CB2 cannabinoid receptors are neuroprotective in Huntington's disease excitotoxicity

    Brain . 132(11): 3152-3164. Number of citations: 260

    [doi:10.1093/brain/awp239]

  • Sagredo O, González S, Aroyo I, Pazos MR, Benito C, Lastres-Becker I, Romero JP, Tolón RM, Mechoulam R, Brouillet E, Romero J, Fernández-Ruiz J.

    Cannabinoid CB2 Receptor Agonists Protect the Striatum Against Malonate Toxicity: Relevance for Huntington's Disease

    Glia . 57(11): 1154-1167. Number of citations: 124

    [doi:10.1002/glia.20838]

  • Tolón RM, Núñez E, Pazos MR, Benito C, Castillo AI, Martínez-Orgado JA, Romero J.

    The activation of cannabinoid CB2 receptors stimulates in situ and in vitro beta-amyloid removal by human macrophages

    BRAIN RESEARCH . 1283: 148-154. Number of citations: 94

    [doi:10.1016/j.brainres.2009.05.098]

  • Pazos MR, Sagredo O, Fernández-Ruiz J.

    The endocannabinoid system in Huntington's disease

    CURRENT PHARMACEUTICAL DESIGN . 14(23): 2317-2325. Number of citations: 57

    [doi:10.2174/138161208785740108]

  • Pazos MR, Tolón RM, Benito C, Rodríguez CF, Gorgojo JJ, Nevado M, Alvarez M, Arias F, Almodóvar F, Fernández MT, Lledó JL, González S, Fernández-Ruiz JJ, Romero J.

    Cannabinoid CB1 receptors are expressed by parietal cells of the human gastric mucosa

    JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY . 56(5): 511-516. Number of citations: 19

    [doi:10.1369/jhc.2008.950741]

  • Fernández-Ruiz J, Pazos MR, García-Arencibia M, Sagredo O, Ramos JA.

    Role of CB2 receptors in neuroprotective effects of cannabinoids

    MOLECULAR AND CELLULAR ENDOCRINOLOGY . 286(1-2, 1): 91-96. Number of citations: 89

    [doi:10.1016/j.mce.2008.01.001]

  • Sagredo O, García-Arencibia M, de Lago E, Finetti S, Decio A, Fernández-Ruiz J.

    Cannabinoids and neuroprotection in basal ganglia disorders

    MOLECULAR NEUROBIOLOGY . 36(1): 82-91. Number of citations: 71

    [doi:10.1007/s12035-007-0004-3]

  • García-Arencibia M, González S, de Lago E, Ramos JA, Mechoulam R, Fernández-Ruiz J.

    Evaluation of the neuroprotective effect of cannabinoids in a rat model of Parkinson's disease: Importance of antioxidant and cannabinoid receptor-independent properties

    BRAIN RESEARCH . 1134(1): 162-170. Number of citations: 206

    [doi:10.1016/j.brainres.2006.11.063]

  • GÓMEZ CAÑAS, MARÍA, FERNÁNDEZ RUIZ, JOSÉ JAVIER.

    Synthesis and pharmacological evaluation of new (E)- and (Z)-3-aryl-4-styryl-1H-pyrazoles as potential cannabinoid ligands

    Arkivoc . 2010: 226-247.

    [doi:10.3998/ark.5550190.0011.a19]