Neurodegenerative diseases: therapy development

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  • Solano RM, Casarejos MJ, Gómez A, Perucho J, de Yébenes JG, Mena MA.

    Parkin Null Cortical Neuronal/Glial Cultures are Resistant to Amyloid-beta(1-42) Toxicity: A Role for Autophagy?

    JOURNAL OF ALZHEIMERS DISEASE . 32(1): 57-76. Number of citations: 11

    [doi:10.3233/JAD-2012-120406]

  • Marco I, Valhondo M, Martín-Fontecha M, Vázquez-Villa H, Del Río J, Planas A, Sagredo O, Ramos JA, Torrecillas IR, Pardo L, Frechilla D, Benhamú B, López-Rodríguez ML.

    New Serotonin 5-HT1A Receptor Agonists with Neuroprotective Effect against Ischemic Cell Damage

    JOURNAL OF MEDICINAL CHEMISTRY . 54(23): 7986-7999. Number of citations: 31

    [doi:10.1021/jm2007886]

  • Cardoso-Silva C, Barbería E, Ramos Atance JA, Maroto M, Hernández A, García-Godoy F.

    Microbiological analysis of gingivitis in pediatric patients under orthodontic treatment

    EUROPEAN JOURNAL OF PAEDIATRIC DENTISTRY . 12(4): 210-214. Number of citations: 8

  • Tapia-González S, Giráldez-Pérez RM, Cuartero MI, Casarejos MJ, Mena MÁ, Wang XF, Sánchez-Capelo A.

    Dopamine and alpha- synuclein dysfunction in Smad3 null mice

    MOLECULAR NEURODEGENERATION . 6: 72-72. Number of citations: 37

    [doi:10.1186/1750-1326-6-72]

  • Lafuente H, Alvarez FJ, Pazos MR, Alvarez A, Rey-Santano MC, Mielgo V, Murgia-Esteve X, Hilario E, Martinez-Orgado J.

    Cannabidiol Reduces Brain Damage and Improves Functional Recovery After Acute Hypoxia-Ischemia in Newborn Pigs

    PEDIATRIC RESEARCH . 70(3): 272-277. Number of citations: 65

    [doi:10.1203/PDR.0b013e3182276b11]

  • Sagredo O, Pazos MR, Satta V, Ramos JA, Pertwee RG, Fernández-Ruiz J.

    Neuroprotective Effects of Phytocannabinoid-Based Medicines in Experimental Models of Huntington's Disease

    JOURNAL OF NEUROSCIENCE RESEARCH . 89(9): 1509-1518. Number of citations: 62

    [doi:10.1002/jnr.22682]

  • Rubio M, Villain H, Docagne F, Roussel BD, Ramos JA, Vivien D, Fernandez-Ruiz J, Ali C.

    Pharmacological Activation/Inhibition of the Cannabinoid System Affects Alcohol Withdrawal-Induced Neuronal Hypersensitivity to Excitotoxic Insults

    Plos One . 6(8): . Number of citations: 15

    [doi:10.1371/journal.pone.0023690]

  • Fernández-Ruiz J, Moreno-Martet M, Rodríguez-Cueto C, Palomo-Garo C, Gómez-Cañas M, Valdeolivas S, Guaza C, Romero J, Guzmán M, Mechoulam R, Ramos JA.

    Prospects for cannabinoid therapies in basal ganglia disorders

    BRITISH JOURNAL OF PHARMACOLOGY . 163(7, SI): 1365-1378. Number of citations: 80

    [doi:10.1111/j.1476-5381.2011.01365.x]

  • García C, Palomo-Garo C, García-Arencibia M, Ramos J, Pertwee R, Fernández-Ruiz J.

    Symptom-relieving and neuroprotective effects of the phytocannabinoid Delta(9)-THCV in animal models of Parkinson's disease

    BRITISH JOURNAL OF PHARMACOLOGY . 163(7, SI): 1495-1506. Number of citations: 124

    [doi:10.1111/j.1476-5381.2011.01278.x]

  • Jazwa A, Rojo AI, Innamorato NG, Hesse M, Fernández-Ruiz J, Cuadrado A.

    Pharmacological Targeting of the Transcription Factor Nrf2 at the Basal Ganglia Provides Disease Modifying Therapy for Experimental Parkinsonism

    ANTIOXIDANTS & REDOX SIGNALING . 14(12): 2347-2360. Number of citations: 214

    [doi:10.1089/ars.2010.3731]

  • Casarejos MJ, Solano RM, Gómez A, Perucho J, de Yébenes JG, Mena MA.

    The accumulation of neurotoxic proteins, induced by proteasome inhibition, is reverted by trehalose, an enhancer of autophagy, in human neuroblastoma cells

    NEUROCHEMISTRY INTERNATIONAL . 58(4): 512-520. Number of citations: 82

    [doi:10.1016/j.neuint.2011.01.008]

  • García-Fernández N, Pérez-Valdivieso JR, Bes-Rastrollo M, Vives M, Lavilla J, Herreros J, Monedero P.

    Timing of Renal Replacement Therapy after Cardiac Surgery: A Retrospective Multicenter Spanish Cohort Study

    BLOOD PURIFICATION . 32(2): 104-111. Number of citations: 35

    [doi:10.1159/000324195]

  • Blázquez C, Chiarlone A, Sagredo O, Aguado T, Pazos MR, Resel E, Palazuelos J, Julien B, Salazar M, Börner C, Benito C, Carrasco C, Diez-Zaera M, Paoletti P, Díaz-Hernández M, Ruiz C, Sendtner M, Lucas JJ, de Yébenes JG, Marsicano G, Monory K, Lutz B, Romero J, Alberch J, Ginés S, Kraus J, Fernández-Ruiz J, Galve-Roperh I, Guzmán M.

    Loss of striatal type 1 cannabinoid receptors is a key pathogenic factor in Huntington's disease

    Brain . 134(1): 119-136. Number of citations: 135

    [doi:10.1093/brain/awq278]

  • Rodríguez-Navarro JA, Rodríguez L, Casarejos MJ, Solano RM, Gómez A, Perucho J, Cuervo AM, García de Yébenes J, Mena MA.

    Trehalose ameliorates dopaminergic and tau pathology in parkin deleted/tau overexpressing mice through autophagy activation

    NEUROBIOLOGY OF DISEASE . 39(3): 423-438. Number of citations: 217

    [doi:10.1016/j.nbd.2010.05.014]

  • Innamorato NG, Jazwa A, Rojo AI, García C, Fernández-Ruiz J, Grochot-Przeczek A, Stachurska A, Jozkowicz A, Dulak J, Cuadrado A.

    Different Susceptibility to the Parkinson's Toxin MPTP in Mice Lacking the Redox Master Regulator Nrf2 or Its Target Gene Heme Oxygenase-1

    Plos One . 5(7): . Number of citations: 104

    [doi:10.1371/journal.pone.0011838]

  • Kurz A, Double KL, Lastres-Becker I, Tozzi A, Tantucci M, Bockhart V, Bonin M, García-Arencibia M, Nuber S, Schlaudraff F, Liss B, Fernández-Ruiz J, Gerlach M, Wüllner U, Lüddens H, Calabresi P, Auburger G, Gispert S.

    A53T-Alpha-Synuclein Overexpression Impairs Dopamine Signaling and Striatal Synaptic Plasticity in Old Mice

    Plos One . 5(7): . Number of citations: 87

    [doi:10.1371/journal.pone.0011464]

  • Fernández-Ruiz J, Hernández M, Ramos JA.

    Cannabinoid-Dopamine Interaction in the Pathophysiology and Treatment of CNS Disorders

    CNS NEUROSCIENCE & THERAPEUTICS . 16(3): 72-91. Number of citations: 115

    [doi:10.1111/j.1755-5949.2010.00144.x]

  • Sagar DR, Jhaveri MD, Richardson D, Gray RA, de Lago E, Fernández-Ruiz J, Barrett DA, Kendall DA, Chapman V.

    Endocannabinoid regulation of spinal nociceptive processing in a model of neuropathic pain

    EUROPEAN JOURNAL OF NEUROSCIENCE . 31(8): 1414-1422. Number of citations: 23

    [doi:10.1111/j.1460-9568.2010.07162.x]