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Biology and Evolution of Microorganisms

The Biology and Evolution of Microorganisms Group, whose head is Dr. Rafael Cantón and which is made up of nine other principal investigators as well as numerous pre- and post-doctoral researchers, technicians and other healthcare personnel, has participated in the last 5 years in 17 national and international research projects and in 15 contracts with pharmaceutical companies or companies dedicated to in vitro diagnostics. During this period of time this work has resulted in more than 190 publications in national and international journals with a high impact index and more than 11 doctoral theses. Likewise, more than 400 communications have been presented at numerous national and international congresses. And all this always seeking the highest excellence in the fields of population biology, antibiotic resistance, respiratory infection, microbiota, metagenomics and HIV.

Search for publications

Only original articles, editorials, guidelines.

  • Ledesma J, Pozo F, Pérez Ruiz M, Navarro JM, Piñeiro L, Montes M, Pérez Castro S, Suárez Fernández J, García Costa J, Fernández M, Galán JC, Cuevas MT, Casas I, Pérez Breña P.

    Substitutions in position 222 of haemagglutinin of pandemic influenza A (H1N1) 2009 viruses in Spain

    JOURNAL OF CLINICAL VIROLOGY . 51(1): 75-78. Number of citations: 26

    [doi:10.1016/j.jcv.2011.01.020]

  • Holguín A, Erazo K, Escobar G, de Mulder M, Yebra G, Martín L, Jovel LE, Castaneda L, Pérez E.

    Drug resistance prevalence in human immunodeficiency virus type 1 infected pediatric populations in Honduras and El Salvador during 1989-2009.

    PEDIATRIC INFECTIOUS DISEASE JOURNAL . 30(5): 82-87. Number of citations: 10

    [doi:10.1097/INF.0b013e3182117289]

  • Curiao T, Cantón R, Garcillán-Barcia MP, de la Cruz F, Baquero F, Coque TM.

    Association of composite IS26-sul3 elements with highly transmissible IncI1 plasmids in extended-spectrum-beta-lactamase-producing Escherichia coli clones from humans.

    ANTIMICROBIAL AGENTS AND CHEMOTHERAPY . 55(5): 2451-2457. Number of citations: 35

    [doi:10.1128/AAC.01448-10]

  • García-Castillo M, del Campo R, Baquero F, Morosini MI, Turrientes MC, Zamora J, Cantón R.

    Stationary biofilm growth normalizes mutation frequencies and mutant prevention concentrations in Pseudomonas aeruginosa from cystic fibrosis patients.

    Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases . 17(5): 704-711. Number of citations: 6

    [doi:10.1111/j.1469-0691.2010.03317.x]

  • Mouton JW, Ambrose PG, Canton R, Drusano GL, Harbarth S, MacGowan A, Theuretzbacher U, Turnidge J.

    Conserving antibiotics for the future: New ways to use old and new drugs from a pharmacokinetic and pharmacodynamic perspective

    DRUG RESISTANCE UPDATES . 14(2): 107-117. Number of citations: 144

    [doi:10.1016/j.drup.2011.02.005]

  • López M, Tenorio C, Del Campo R, Zarazaga M, Torres C.

    Characterization of the mechanisms of fluoroquinolone resistance in vancomycin-resistant enterococci of different origins.

    JOURNAL OF CHEMOTHERAPY . 23(2): 87-91. Number of citations: 15

    [doi:10.1179/joc.2011.23.2.87]

  • Gagliotti C, Balode A, Baquero F, Degener J, Grundmann H, Gür D, Jarlier V, Kahlmeter G, Monen J, Monnet DL, Rossolini GM, Suetens C, Weist K, Heuer O.

    Escherichia coli and Staphylococcus aureus: bad news and good news from the European Antimicrobial Resistance Surveillance Network (EARS-Net, formerly EARSS), 2002 to 2009.

    Eurosurveillance . 16(11): .

  • Cuevas O, Oteo J, Lázaro E.

    Significant ecological impact on the progression of fluoroquinolone resistance in Escherichia coli with increased community use of moxifloxacin, levofloxacin and amoxicillin/clavulanic acid.

    The Journal of antimicrobial chemotherapy . 66(3): 664-669. Number of citations: 42

    [doi:10.1093/jac/dkq471]

  • García-Descalzo L, Alcazar A, Baquero F, Cid C.

    Identification of in vivo HSP90-interacting proteins reveals modularity of HSP90 complexes is dependent on the environment in psychrophilic bacteria.

    CELL STRESS & CHAPERONES . 16(2): 203-218. Number of citations: 28

    [doi:10.1007/s12192-010-0233-7]

  • Freitas AR, Coque TM, Novais C, Hammerum AM, Lester CH, Zervos MJ, Donabedian S, Jensen LB, Francia MV, Baquero F, Peixe L.

    Human and swine hosts share vancomycin-resistant Enterococcus faecium CC17 and CC5 and Enterococcus faecalis CC2 clonal clusters harboring Tn1546 on indistinguishable plasmids.

    JOURNAL OF CLINICAL MICROBIOLOGY . 49(3): 925-931. Number of citations: 104

    [doi:10.1128/JCM.01750-10]

  • Werner G, Freitas AR, Coque TM, Sollid JE, Lester C, Hammerum AM, Garcia-Migura L, Jensen LB, Francia MV, Witte W, Willems RJ, Sundsfjord A.

    Host range of enterococcal vanA plasmids among Gram-positive intestinal bacteria.

    The Journal of antimicrobial chemotherapy . 66(2): 273-282. Number of citations: 47

    [doi:10.1093/jac/dkq455]

  • Laverde Gomez JA, van Schaik W, Freitas AR, Coque TM, Weaver KE, Francia MV, Witte W, Werner G.

    A multiresistance megaplasmid pLG1 bearing a hylEfm genomic island in hospital Enterococcus faecium isolates.

    INTERNATIONAL JOURNAL OF MEDICAL MICROBIOLOGY . 301(2): 165-175. Number of citations: 60

    [doi:10.1016/j.ijmm.2010.08.015]

  • Yebra G, de Mulder M, Martín L, Pérez-Cachafeiro S, Rodríguez C, Labarga P, García F, Tural C, Jaén A, Navarro G, Holguín A.

    Sensitivity of seven HIV subtyping tools differs among subtypes/recombinants in the Spanish cohort of naïve HIV-infected patients (CoRIS).

    ANTIVIRAL RESEARCH . 89(1): 19-25. Number of citations: 19

    [doi:10.1016/j.antiviral.2010.10.008]

  • Cantón R, Lumb J.

    Emerging resistance in Gram-negative pathogens and implications for clinical practice.

    Future Microbiology . 6(1): 19-22.

    [doi:10.2217/fmb.10.150]

  • Asensio A, Alvarez-Espejo T, Fernandez-Crehuet J, Ramos A, Vaque-Rafart J, Bishopberger C, Hernandez Navarrete M, Calbo-Torrecillas F, Campayo J, Canton R.

    Trends in yearly prevalence of third-generation cephalosporin and fluoroquinolone resistant Enterobacteriaceae infections and antimicrobial use in Spanish hospitals, Spain, 1999 to 2010.

    Eurosurveillance . 16(40): .

  • Gorantla S, Makarov E, Finke-Dwyer J, Castanedo A, Holguin A, Gebhart CL, Gendelman HE, Poluektova L.

    Links between progressive HIV-1 infection of humanized mice and viral neuropathogenesis.

    AMERICAN JOURNAL OF PATHOLOGY . 177(6): 2938-2949. Number of citations: 71

    [doi:10.2353/ajpath.2010.100536]

  • de Arellano ER, Alcamí J, López M, Soriano V, Holguín A.

    Drastic decrease of transcription activity due to hypermutated long terminal repeat (LTR) region in different HIV-1 subtypes and recombinants.

    ANTIVIRAL RESEARCH . 88(2): 152-159. Number of citations: 9

    [doi:10.1016/j.antiviral.2010.08.007]

  • Tato M, Morosini M, García L, Albertí S, Coque MT, Cantón R.

    Carbapenem Heteroresistance in VIM-1-Producing Klebsiella pneumoniae Isolates Belonging to the Same Clone: Consequences for Routine Susceptibility Testing

    JOURNAL OF CLINICAL MICROBIOLOGY . 48(11): 4089-4093. Number of citations: 48

    [doi:10.1128/JCM.01130-10]