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Biology and Evolution of Microorganisms

The Biology and Evolution of Microorganisms Group, whose head is Dr. Rafael Cantón and which is made up of nine other principal investigators as well as numerous pre- and post-doctoral researchers, technicians and other healthcare personnel, has participated in the last 5 years in 17 national and international research projects and in 15 contracts with pharmaceutical companies or companies dedicated to in vitro diagnostics. During this period of time this work has resulted in more than 190 publications in national and international journals with a high impact index and more than 11 doctoral theses. Likewise, more than 400 communications have been presented at numerous national and international congresses. And all this always seeking the highest excellence in the fields of population biology, antibiotic resistance, respiratory infection, microbiota, metagenomics and HIV.

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Only original articles, editorials, guidelines.

  • Scheuerman O, Schechner V, Carmeli Y, Gutiérrez-Gutiérrez B, Calbo E, Almirante B, Viale PL, Oliver A, Ruiz-Garbajosa P, Gasch O, Gozalo M, Pitout J, Akova M, Peña C, Molina J, Hernández-Torres A, Venditti M, Prim N, Origüen J, Bou G, Tacconelli E, Tumbarello M, Hamprecht A, Karaiskos I, de la Calle C, Pérez F, Schwaber MJ, Bermejo J, Lowman W, Hsueh PR, Navarro-San Francisco C, Bonomo RA, Paterson DL, Pascual A, Rodríguez-Baño J, REIPI/ESGBIS/INCREMENT investigators.

    Comparison of Predictors and Mortality Between Bloodstream Infections Caused by ESBL-Producing Escherichia coli and ESBL-Producing Klebsiella pneumoniae.

    INFECTION CONTROL AND HOSPITAL EPIDEMIOLOGY . 39(6): 660-667. Number of citations: 31

    [doi:10.1017/ice.2018.63]

  • Frost I, Smith WPJ, Mitri S, Millan AS, Davit Y, Osborne JM, Pitt-Francis JM, MacLean RC, Foster KR.

    Cooperation, competition and antibiotic resistance in bacterial colonies.

    ISME JOURNAL . 12(6): 1582-1593. Number of citations: 74

    [doi:10.1038/s41396-018-0090-4]

  • Rodríguez-Castro E, Trastoy R, Rodríguez-Osorio X, Domínguez-Santalla MJ, Fernández-Lebrero A, González-Alba JM, Aguilera A.

    Meningitis due to autochthonous acute infection with hepatitis E virus in a chef: a case report.

    The Journal of antimicrobial chemotherapy . 73(6): 1726-1728. Number of citations: 2

    [doi:10.1093/jac/dky052]

  • Macià MD, Del Pozo JL, Díez-Aguilar M, Guinea J.

    Microbiological diagnosis of biofilm-related infections.

    ENFERMEDADES INFECCIOSAS Y MICROBIOLOGIA CLINICA . 36(6): 375-381. Number of citations: 13

    [doi:10.1016/j.eimc.2017.04.006]

  • Martínez-García L, González-Alba JM, Baquero F, Cantón R, Galán JC.

    Ceftazidime Is the Key Diversification and Selection Driver of VIM-Type Carbapenemases.

    Mbio . 9(3): . Number of citations: 9

    [doi:10.1128/mBio.02109-17]

  • Escudero JA, MacLean RC, San Millan A.

    Testing the Role of Multicopy Plasmids in the Evolution of Antibiotic Resistance.

    JOVE-JOURNAL OF VISUALIZED EXPERIMENTS . (135): .

    [doi:10.3791/57386]

  • Fernández-Martínez M, Ruiz Del Castillo B, Lecea-Cuello MJ, Rodríguez-Baño J, Pascual Á, Martínez-Martínez L.

    Prevalence of Aminoglycoside-Modifying Enzymes in Escherichia coli and Klebsiella pneumoniae Producing Extended Spectrum -Lactamases Collected in Two Multicenter Studies in Spain.

    MICROBIAL DRUG RESISTANCE . 24(4): 367-376. Number of citations: 16

    [doi:10.1089/mdr.2017.0102]

  • Canton R, Morrissey I, Vila J, Tato M, García-Castillo M, López Y, Gargallo-Viola D, Zsolt I.

    Comparative in vitro antibacterial activity of ozenoxacin against Gram-positive clinical isolates.

    Future Microbiology . 13(6): 3-19. Number of citations: 18

    [doi:10.2217/fmb-2017-0289]

  • Rodriguez-Beltran J, Hernandez-Beltran JCR, DelaFuente J, Escudero JA, Fuentes-Hernandez A, MacLean RC, Peña-Miller R, San Millan A.

    Multicopy plasmids allow bacteria to escape from fitness trade-offs during evolutionary innovation.

    Nature Ecology & Evolution . 2(5): 873-881. Number of citations: 36

    [doi:10.1038/s41559-018-0529-z]

  • Angers-Loustau A, Petrillo M, Bengtsson-Palme J, Berendonk T, Blais B, Chan KG, Coque TM, Hammer P, Heß S, Kagkli DM, Krumbiegel C, Lanza VF, Madec JY, Naas T, O'Grady J, Paracchini V, Rossen JWA, Ruppé E, Vamathevan J, Venturi V, Van den Eede G.

    The challenges of designing a benchmark strategy for bioinformatics pipelines in the identification of antimicrobial resistance determinants using next generation sequencing technologies.

    F1000Research . 7: 459-459.

    [doi:10.12688/f1000research.14509.2]

  • Cantón R, Loza E, Aznar J, Barrón-Adúriz R, Calvo J, Castillo FJ, Cercenado E, Cisterna R, González-Romo F, López-Hontangas JL, Suárez-Barrenechea AI, Tubau F, Molloy B, López-Mendoza D.

    Antimicrobial susceptibility trends and evolution of isolates with extended spectrum ß-lactamases among Gram-negative organisms recovered during the SMART study in Spain (2011-2015).

    REVISTA ESPANOLA DE QUIMIOTERAPIA . 31(2): 136-145. Number of citations: 9

  • Navarro-San Francisco C, Ruiz-Garbajosa P, Cantón R.

    The what, when and how in performing and interpreting microbiological diagnostic tests in skin and soft tissue infections.

    CURRENT OPINION IN INFECTIOUS DISEASES . 31(2): 104-112. Number of citations: 9

    [doi:10.1097/QCO.0000000000000433]

  • Díez-Aguilar M, Conejo MC, Morosini MI, Palop NT, Gimeno C, Cantón R, Pascual Á.

    Susceptibility testing and detection of ß-lactam resistance mechanisms in Enterobacteriaceae: a multicentre national proficiency study.

    INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS . 51(4): 612-619. Number of citations: 3

    [doi:10.1016/j.ijantimicag.2017.12.008]

  • Abodakpi H, Chang KT, Sánchez Díaz AM, Cantón R, Lasco TM, Chan K, Sofjan AK, Tam VH.

    Prevalence of extended-spectrum beta-lactamase and carbapenemase-producing bloodstream isolates of Klebsiella pneumoniae in a tertiary care hospital.

    JOURNAL OF CHEMOTHERAPY . 30(2): 115-119. Number of citations: 6

    [doi:10.1080/1120009X.2017.1399233]

  • Del Campo-Moreno R, Alarcón-Cavero T, D'Auria G, Delgado-Palacio S, Ferrer-Martínez M.

    Microbiota and Human Health: characterization techniques and transference.

    ENFERMEDADES INFECCIOSAS Y MICROBIOLOGIA CLINICA . 36(4): 241-245. Number of citations: 2

    [doi:10.1016/j.eimc.2017.02.007]

  • Toledo D, Soldevila N, Torner N, Pérez-Lozano MJ, Espejo E, Navarro G, Egurrola M, Domínguez Á.

    Factors associated with 30-day readmission after hospitalisation for community-acquired pneumonia in older patients: a cross-sectional study in seven Spanish regions.

    BMJ open . 8(3): . Number of citations: 17

    [doi:10.1136/bmjopen-2017-020243]

  • Ares-Arroyo M, Bernabe-Balas C, Santos-Lopez A, Baquero MR, Prasad KN, Cid D, Martin-Espada C, San Millan A, Gonzalez-Zorn B.

    PCR-Based Analysis of ColE1 Plasmids in Clinical Isolates and Metagenomic Samples Reveals Their Importance as Gene Capture Platforms.

    FRONTIERS IN MICROBIOLOGY . 9: 469-469. Number of citations: 17

    [doi:10.3389/fmicb.2018.00469]

  • Rondy M, Kissling E, Emborg HD, Gherasim A, Pebody R, Trebbien R, Pozo F, Larrauri A, McMenamin J, Valenciano M, I-MOVE/I-MOVE+ group.

    Interim 2017/18 influenza seasonal vaccine effectiveness: combined results from five European studies.

    Eurosurveillance . 23(9): . Number of citations: 46

    [doi:10.2807/1560-7917.ES.2018.23.9.18-00086]