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Translational Haematology

Our Translational Hematology group was created with the aim of generating knowledge in the field of hematology and collaborating with other groups for the implementation of projects. Our activity is based on a broad portfolio of clinical trials, basic research projects and registry studies. The area of ​​knowledge in which we focus is the study of the immune system and its relationship with oncohematological diseases and their infectious complications, cell therapy, study of the adverse effects of drugs and optimization in obtaining and using blood components in Transfusion Therapy.

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Only original articles, editorials, guidelines.

  • Serrano J, Martínez-Cuadrón D, Gil C, Bernal T, Tormo M, Martínez-Sánchez P, Rodríguez-Medina C, Herrera P, Simón JAP, Sayas MJ, Bergua J, Lavilla-Rubira E, Amigo M, Benavente C, Lorenzo JLL, Pérez-Encinas MM, Vidriales MB, Aparicio-Pérez C, Torres EP, Colorado M, de Rueda B, García-Boyero R, Marini S, García-Suárez J, López-Pavía M, Gómez-Roncero MI, Noriega V, López A, Labrador J, Cabello A, Sossa C, Algarra L, Stevenazzi M, Torres L, Boluda B, Sánchez-Garcia J, Montesinos P.

    Autologous or Allogeneic Hematopoietic Stem Cell Transplantation as Front-Line Treatment for Adult Secondary Acute Myeloid Leukemia Patients: The PETHEMA Registry Experience

    Transplantation and Cellular Therapy . 31(5): 2991-29914.

    [doi:10.1016/j.jtct.2025.02.011]

  • Manubens A, Paiva B, Gutiérrez NC, Fernandez M, Calasanz MJ, Rosiñol L, Oriol A, Blanchard MJ, Carrillo E, Benavente C, Martínez-López J, Bargay J, Hernández MT, de la Rubia J, González Y, Paricio M, de Arriba F, Ocio EM, Teruel AI, de la Guia AL, Sirvent M, Gironella M, Sampol A, Arguiñano JM, Cabrera C, Alegre A, Granell M, Cabañas V, Núñez-Córdoba JM, Mateos MV, Lahuerta JJ, San Miguel JF, Bladé J, Rodriguez-Otero P.

    High-risk features of early relapse in newly-diagnosed multiple myeloma: The impact of cytogenetics and response to initial therapy

    HemaSphere . 9(4): . Number of citations: 2

    [doi:10.1002/hem3.70127]

  • Gómez-Seguí I, Cid J, Lozano M, Mingot-Castellano ME, Pascual-Izquierdo C, Gonzalez Del Castillo LM, Vidan Estevez JM, Garcia-Candel F, Jiménez Balarezo M, Valcarcel D, Cuellar Perez-Avila C, Arraiz Ramirez M, Lakhwani S, Moreno Jimenez MG, Oliva Hernandez AY, Garcia Gala JM, Martinez Nieto J, Goterris R, Fernández Docampo M, Sopeña Pell-Ilderton C, de la Rubia J.

    Caplacizumab treatment in elderly patients with iTTP: Experience from the Spanish TTP Registry

    HemaSphere . 9(4): . Number of citations: 2

    [doi:10.1002/hem3.70109]

  • Luna A, Devlin SM, Rejeski K, Flynn JR, Corona M, Luttwak E, Rivas-Delgado A, Landego I, Cassanello G, Gomez-Llobell M, Raj SS, Dahi PB, Lin RJ, Parascondola A, Palomba ML, Shah GL, Scordo M, Alarcon Tomas A, Leithner D, Bedmutha A, Schöder H, Imber BS, Salles G, Park JH, Perales MA, Shouval R.

    CAR T-cell therapy response varies by extranodal disease site in large B-cell lymphoma

    Blood Cancer Journal . 15(1): 64-64. Number of citations: 8

    [doi:10.1038/s41408-025-01273-1]

  • Costa I Colomer J, Garcia-Moyano M, Maiz L, Perez-Tarazona S, Ruiz de Valbuena M, Ceberio L, Correcher P, Juliá-Palacios N, Morales M, Pérez-Yagüe G, Villarrubia J, Pérez-Rojo R.

    The impact of interstitial lung disease in patients with acid sphingomyelinase deficiency (ASMD) - A case series.

    Respiratory Medicine Case Reports . 55: 102202-102202. Number of citations: 1

    [doi:10.1016/j.rmcr.2025.102202]

  • Corona M, Ip A, Brown S, Luna A, Khatib H, Flynn JR, Devlin SM, Landego I, Cassanello G, Rejeski K, Zuckerman T, Dahi PB, Scordo M, Lin RJ, Kabat M, Luttwak E, Pavkovic E, Palomba ML, Park J, Salles G, Schoder H, Leithner D, Leslie LA, Perales MA, Beyar-Katz O, Shah GL, Shouval R.

    Treatment failure patterns in early versus late introduction of CAR T-cell therapy in large B-cell lymphoma

    BONE MARROW TRANSPLANTATION . 60(4): 491-498. Number of citations: 7

    [doi:10.1038/s41409-025-02519-z]

  • Stock CN, Chillón CJ, Hernández CL, Moro FM, Palomanes JM, Villaespesa MP, De Abia AL, Santiago ER, Martín ER, Rodríguez AC, Gutiérrez VG, Jiménez GM, Jiménez JL, Puente PH.

    Combination of disease burden before allogeneic transplantation and early post-transplant minimal residual disease predicts survival in patients with acute myeloid leukemia

    ANNALS OF HEMATOLOGY . 104(4): 2469-2481. Number of citations: 1

    [doi:10.1007/s00277-025-06325-x]

  • Sureda A, García-Sanz R, Domingo-Domenech E, Capote FJ, Gutiérrez A, Rodriguez A, Aguiar D, Giraldo P, Infante MS, López-Jiménez J, Martínez C, Sánchez-González B, Ortiz-Romero PL, Grande M, Baeza-Montañez L.

    Retreatment with Brentuximab Vedotin in Patients with Relapsed/Refractory CD30+ Malignancies: A Retrospective Medical Chart Review Study in Spain-The BELIEVE Study.

    Cancers . 17(7): . Number of citations: 6

    [doi:10.3390/cancers17071137]

  • Riedell, Peter A., Grady, Connor B., Nastoupil, Loretta J., Luna, Alejandro, Ahmed, Nausheen, Maziarz, Richard T., Hu, Marie, Brower, Jamie, Hwang, Wei-Ting, Schuster, Stephen J., Chen, Andy I., Oluwole, Olalekan O., Bachanova, Veronika, Mcgurik, Joseph P., Perales, Miguel-Angel, Bishop, Michael R., Porter, David L..

    Lisocabtagene maraleucel for relapsed/refractory large B-cell lymphoma: a cell therapy consortium real-world analysis

    Blood Advances . 9(5): 1232-1241. Number of citations: 29

    [doi:10.1182/bloodadvances.2024014164]

  • Cortes JE, Kim DW, Saikia T, Khattry N, Rathnam K, Alvarado Y, Hannah G, Tantravahi SK, Apperley JF, Charbonnier A, García-Gutiérrez V, Lucchesi A, Dima D, Illés Á, Popov VM, Abruzzese E, Nag A, Apte S, Badar T, Yao SL, Saxena U, Sreenivasan J, Inamdar S, Chimote G, Nicolini FE.

    Vodobatinib for patients with Philadelphia chromosome-positive chronic myeloid leukaemia resistant or intolerant to multiple lines of previous therapy: an open-label, multicentre, phase 1/2 trial.

    Lancet Haematology . 12(3): . Number of citations: 9

    [doi:10.1016/S2352-3026(24)00354-5]

  • Boluda B, Rodriguez-Veiga R, Sargas C, Ayala R, Larráyoz MJ, Chillón MC, Soria-Saldise E, Bilbao C, Prados de la Torre E, Navarro I, Martinez-Cuadron D, Gil C, Bernal T, Bergua J, Algarra L, Tormo M, Martínez-Sanchez P, Carrillo-Cruz E, Serrano J, Alonso-Domínguez JM, García R, Amigo ML, Herrera-Puente P, Sayas MJ, Lavilla-Rubira E, García-Pérez MJ, Morán J, Pérez-Santaolalla E, Alonso-Vence N, Oliva A, López JA, Barrios M, García-Fortes M, Olave MT, Labrador J, Martínez-López J, Calasanz MJ, García-Sanz R, Pérez-Simón JA, Gómez-Casares MT, Sánchez-Garcia J, Mendizabal Y, Barragán E, Montesinos P.

    Conventional PCR Versus Next Generation Sequencing for Diagnosis of FLT3, IDH and NPM1 Mutations in Acute Myeloid Leukemia: Results of the PETHEMA PCR-LMA Study

    Cancers . 17(5): . Number of citations: 3

    [doi:10.3390/cancers17050854]

  • Velasco-Rodríguez D, Martínez-Alfonzo I, Velasco-Valdazo AE, Domingo-González A, Revilla N, Mahíllo-Fernández I, Askari E, Blanchard MJ, Vidal Laso R, Fernández-Cuezva L, Castro-Quismondo N, Prieto E, Serrano-López J, Rosado B, Naya D, Martín-Herrero S, Menéndez M, Yuste M, Sánchez-Prieto I, Jiménez-Martín A, Bueno MÁ, de la Plaza R, Martínez-López J, Calvo-Villas JM, López-Jiménez J, Llamas-Sillero P.

    Significant attenuation of fully automated thrombin generation in newly diagnosed multiple myeloma patients after induction therapy

    JOURNAL OF THROMBOSIS AND THROMBOLYSIS . 58(3): 467-480.

    [doi:10.1007/s11239-025-03079-1]

  • Villarrubia J, Morales M, Ceberio L, Vitoria I, Bellusci M, Quiñones I, Peña L, Ruiz de Valbuena M, O'Callaghan M.

    Ecological study to estimate the prevalence of patients with acid sphingomyelinase deficiency in Spain. PREVASMD study.

    Revista clinica espanola . 225(2): 70-77.

    [doi:10.1016/j.rceng.2024.11.007]

  • Pascual-Izquierdo C, Llacer-Ferrandis MJ, de-la-Iglesia A, Monsalvo-Saornil S, Menor-Gómez M, Gil-Fernández JJ, Chica-Gullon E, Álvarez-Román MT, Perez-Segura G, Zafra D, Ortuzar-Pasalodos A, González-Gascón-Y-Marín IT, Moreno G, Arquero-Portero T, Moreno-Carbonell M, Revilla N.

    Avatrombopag in adults with immune thrombocytopenia: A multicentre real-life observational study in Madrid, Spain (AVAMAD study)

    BRITISH JOURNAL OF HAEMATOLOGY . 206(2): 652-656. Number of citations: 8

    [doi:10.1111/bjh.19975]

  • Valtis YK, Devlin SM, Shouval R, Rejeski K, Corona M, Luna De Abia A, Rivas-Delgado A, Luttwak E, Cassanello G, Landego I Dr, Schöder H, Bedmutha A, Boardman AP, Shah GL, Scordo M, Perales MA, Salles GA, Palomba ML, Shah UA, Park JH.

    Cancer cachexia and weight loss before CAR T-cell therapy for lymphoma are independently associated with poor outcomes

    Blood Advances . 9(1): 151-161. Number of citations: 14

    [doi:10.1182/bloodadvances.2024014555]

  • Melica G, Luna de Abia A, Shah GL, Devlin S, Corona M, Fein J, Dahi PB, Giralt SA, Lin RJ, Palomba ML, Parascondola A, Park J, Salles G, Saldia A, Scordo M, Shouval R, Perales MA, Seo SK.

    Shift from Widespread to Tailored Antifungal Prophylaxis in Lymphoma Patients Treated with CD19 CAR T Cell Therapy: Results from a Large Retrospective Cohort

    Transplantation and Cellular Therapy . 31(1): 36-44. Number of citations: 11

    [doi:10.1016/j.jtct.2024.10.010]

  • Rodríguez-Arbolí E, Rodríguez-Veiga R, Soria-Saldise E, Bergua JM, Caballero-Velázquez T, Arnán M, Vives S, Serrano J, Bernal T, Martínez-Sánchez P, Tormo M, Rodríguez-Medina C, Herrera-Puente P, Lavilla-Rubira E, Boluda B, Acuña-Cruz E, Cano I, Cáceres S, Ballesteros J, Falantes J, Martínez-Cuadrón D, Pérez-Simón JA, Montesinos P.

    A phase 2, multicenter, clinical trial of CPX-351 in older patients with secondary or high-risk acute myeloid leukemia: PETHEMA-LAMVYX.

    CANCER . 131(1): . Number of citations: 2

    [doi:10.1002/cncr.35618]

  • Fernández de Larrea C, Loscertales J, Cabañas V, Freiria C, Blanchard MJ, Askari E, Lorenzo Pérez M, Abril L, López Pardo J, Pinzón S, Díaz Gálvez J, Amer N, Ramírez Páyer Á, García Sánchez R, Alcalá MM, Capote FJ, Moreno D, Bolumburu C, Rubio-Azpeitia E, García Sanz R.

    Observational retrospective study of the treatment of Waldenstrom's macroglobulinemia with ibrutinib in routine clinical practice in Spain.

    Therapeutic Advances in Hematology . 16: .

    [doi:10.1177/20406207251379670]