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Translational Haematology

Our Translational Hematology group was created with the aim of generating knowledge in the field of hematology and collaborating with other groups for the implementation of projects. Our activity is based on a broad portfolio of clinical trials, basic research projects and registry studies. The area of ​​knowledge in which we focus is the study of the immune system and its relationship with oncohematological diseases and their infectious complications, cell therapy, study of the adverse effects of drugs and optimization in obtaining and using blood components in Transfusion Therapy.

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Only original articles, editorials, guidelines.

  • Manubens A, Paiva B, Gutiérrez NC, Fernandez M, Calasanz MJ, Rosiñol L, Oriol A, Blanchard MJ, Carrillo E, Benavente C, Martínez-López J, Bargay J, Hernández MT, de la Rubia J, González Y, Paricio M, de Arriba F, Ocio EM, Teruel AI, de la Guia AL, Sirvent M, Gironella M, Sampol A, Arguiñano JM, Cabrera C, Alegre A, Granell M, Cabañas V, Núñez-Córdoba JM, Mateos MV, Lahuerta JJ, San Miguel JF, Bladé J, Rodriguez-Otero P.

    High-risk features of early relapse in newly-diagnosed multiple myeloma: The impact of cytogenetics and response to initial therapy.

    Hemasphere . 9(4): .

    [doi:10.1002/hem3.70127]

  • Gómez-Seguí I, Cid J, Lozano M, Mingot-Castellano ME, Pascual-Izquierdo C, Gonzalez Del Castillo LM, Vidan Estevez JM, Garcia-Candel F, Jiménez Balarezo M, Valcarcel D, Cuellar Perez-Avila C, Arraiz Ramirez M, Lakhwani S, Moreno Jimenez MG, Oliva Hernandez AY, Garcia Gala JM, Martinez Nieto J, Goterris R, Fernández Docampo M, Sopeña Pell-Ilderton C, de la Rubia J.

    Caplacizumab treatment in elderly patients with iTTP: Experience from the Spanish TTP Registry.

    Hemasphere . 9(4): .

    [doi:10.1002/hem3.70109]

  • Luna A, Devlin SM, Rejeski K, Flynn JR, Corona M, Luttwak E, Rivas-Delgado A, Landego I, Cassanello G, Gomez-Llobell M, Raj SS, Dahi PB, Lin RJ, Parascondola A, Palomba ML, Shah GL, Scordo M, Alarcon Tomas A, Leithner D, Bedmutha A, Schöder H, Imber BS, Salles G, Park JH, Perales MA, Shouval R.

    CAR T-cell therapy response varies by extranodal disease site in large B-cell lymphoma.

    BLOOD CANCER JOURNAL . 15(1): 64-64.

    [doi:10.1038/s41408-025-01273-1]

  • Costa I Colomer J, Garcia-Moyano M, Maiz L, Perez-Tarazona S, Ruiz de Valbuena M, Ceberio L, Correcher P, Juliá-Palacios N, Morales M, Pérez-Yagüe G, Villarrubia J, Pérez-Rojo R.

    The impact of interstitial lung disease in patients with acid sphingomyelinase deficiency (ASMD) - A case series.

    Respiratory Medicine Case Reports . 55: 102202-102202.

    [doi:10.1016/j.rmcr.2025.102202]

  • Corona M, Ip A, Brown S, Luna A, Khatib H, Flynn JR, Devlin SM, Landego I, Cassanello G, Rejeski K, Zuckerman T, Dahi PB, Scordo M, Lin RJ, Kabat M, Luttwak E, Pavkovic E, Palomba ML, Park J, Salles G, Schoder H, Leithner D, Leslie LA, Perales MA, Beyar-Katz O, Shah GL, Shouval R.

    Treatment failure patterns in early versus late introduction of CAR T-cell therapy in large B-cell lymphoma.

    BONE MARROW TRANSPLANTATION . 60(4): 491-498.

    [doi:10.1038/s41409-025-02519-z]

  • Sureda A, García-Sanz R, Domingo-Domenech E, Capote FJ, Gutiérrez A, Rodriguez A, Aguiar D, Giraldo P, Infante MS, López-Jiménez J, Martínez C, Sánchez-González B, Ortiz-Romero PL, Grande M, Baeza-Montañez L.

    Retreatment with Brentuximab Vedotin in Patients with Relapsed/Refractory CD30+ Malignancies: A Retrospective Medical Chart Review Study in Spain-The BELIEVE Study.

    Cancers . 17(7): .

    [doi:10.3390/cancers17071137]

  • Velasco-Rodríguez D, Martínez-Alfonzo I, Velasco-Valdazo AE, Domingo-González A, Revilla N, Mahíllo-Fernández I, Askari E, Blanchard MJ, Vidal Laso R, Fernández-Cuezva L, Castro-Quismondo N, Prieto E, Serrano-López J, Rosado B, Naya D, Martín-Herrero S, Menéndez M, Yuste M, Sánchez-Prieto I, Jiménez-Martín A, Bueno MÁ, de la Plaza R, Martínez-López J, Calvo-Villas JM, López-Jiménez J, Llamas-Sillero P.

    Significant attenuation of fully automated thrombin generation in newly diagnosed multiple myeloma patients after induction therapy.

    JOURNAL OF THROMBOSIS AND THROMBOLYSIS . 58(3): 467-480.

    [doi:10.1007/s11239-025-03079-1]

  • Boluda B, Rodriguez-Veiga R, Sargas C, Ayala R, Larráyoz MJ, Chillón MC, Soria-Saldise E, Bilbao C, Prados de la Torre E, Navarro I, Martinez-Cuadron D, Gil C, Bernal T, Bergua J, Algarra L, Tormo M, Martínez-Sanchez P, Carrillo-Cruz E, Serrano J, Alonso-Domínguez JM, García R, Amigo ML, Herrera-Puente P, Sayas MJ, Lavilla-Rubira E, García-Pérez MJ, Morán J, Pérez-Santaolalla E, Alonso-Vence N, Oliva A, López JA, Barrios M, García-Fortes M, Olave MT, Labrador J, Martínez-López J, Calasanz MJ, García-Sanz R, Pérez-Simón JA, Gómez-Casares MT, Sánchez-Garcia J, Mendizabal Y, Barragán E, Montesinos P.

    Conventional PCR Versus Next Generation Sequencing for Diagnosis of FLT3, IDH and NPM1 Mutations in Acute Myeloid Leukemia: Results of the PETHEMA PCR-LMA Study.

    Cancers . 17(5): .

    [doi:10.3390/cancers17050854]

  • Cortes JE, Kim DW, Saikia T, Khattry N, Rathnam K, Alvarado Y, Hannah G, Tantravahi SK, Apperley JF, Charbonnier A, García-Gutiérrez V, Lucchesi A, Dima D, Illés Á, Popov VM, Abruzzese E, Nag A, Apte S, Badar T, Yao SL, Saxena U, Sreenivasan J, Inamdar S, Chimote G, Nicolini FE.

    Vodobatinib for patients with Philadelphia chromosome-positive chronic myeloid leukaemia resistant or intolerant to multiple lines of previous therapy: an open-label, multicentre, phase 1/2 trial.

    LANCET HAEMATOLOGY . 12(3): .

    [doi:10.1016/S2352-3026(24)00354-5]

  • Pascual-Izquierdo C, Llacer-Ferrandis MJ, de-la-Iglesia A, Monsalvo-Saornil S, Menor-Gómez M, Gil-Fernández JJ, Chica-Gullon E, Álvarez-Román MT, Perez-Segura G, Zafra D, Ortuzar-Pasalodos A, González-Gascón-Y-Marín IT, Moreno G, Arquero-Portero T, Moreno-Carbonell M, Revilla N.

    Avatrombopag in adults with immune thrombocytopenia: A multicentre real-life observational study in Madrid, Spain (AVAMAD study).

    BRITISH JOURNAL OF HAEMATOLOGY . 206(2): 652-656.

    [doi:10.1111/bjh.19975]

  • Villarrubia J, Morales M, Ceberio L, Vitoria I, Bellusci M, Quiñones I, Peña L, Ruiz de Valbuena M, O'Callaghan M.

    Ecological study to estimate the prevalence of patients with acid sphingomyelinase deficiency in Spain. PREVASMD study.

    Revista clinica espanola . 225(2): 70-77.

    [doi:10.1016/j.rceng.2024.11.007]

  • Valtis YK, Devlin SM, Shouval R, Rejeski K, Corona M, Luna De Abia A, Rivas-Delgado A, Luttwak E, Cassanello G, Landego I Dr, Schöder H, Bedmutha A, Boardman AP, Shah GL, Scordo M, Perales MA, Salles GA, Palomba ML, Shah UA, Park JH.

    Cancer cachexia and weight loss prior to CAR T-cell therapy for lymphoma are independently associated with poor outcomes.

    Blood Advances . 9(1): 151-161.

    [doi:10.1182/bloodadvances.2024014555]

  • Rodríguez-Arbolí E, Rodríguez-Veiga R, Soria-Saldise E, Bergua JM, Caballero-Velázquez T, Arnán M, Vives S, Serrano J, Bernal T, Martínez-Sánchez P, Tormo M, Rodríguez-Medina C, Herrera-Puente P, Lavilla-Rubira E, Boluda B, Acuña-Cruz E, Cano I, Cáceres S, Ballesteros J, Falantes J, Martínez-Cuadrón D, Pérez-Simón JA, Montesinos P.

    A phase 2, multicenter, clinical trial of CPX-351 in older patients with secondary or high-risk acute myeloid leukemia: PETHEMA-LAMVYX.

    CANCER . 131(1): .

    [doi:10.1002/cncr.35618]

  • Escamilla-Gómez V, García Gutiérrez V, Alcalde-Mellado P, Astibia-Mahillo B, Chinea-Rodriguez A, López-Corral L, Acera-Gómez M, Torres Ochando MK, Borrero Borrego A, González Pinedo L, Zudaire Ripa T, González Vicent M, Benzaquén A, Izquierdo Garcia I, Asensi Cantó P, Montoro J, Martín-Domínguez FM, Orti G, Valcárcel D, Benitez-Carabante MI, Diaz-de-Heredia C, Cañamero E, Ferrá C, García-Cadenas I, Redondo S, Sisinni L, Perez-Martínez A, Mussetti A, Garcia-Mañó L, Palomo-Moraleda MDP, González-Sierra PA, Jurado M, Perez-Simon JA.

    Ruxolitinib in acute and chronic graft-versus-host disease: real life long-term experience in a multi-center study for adult and pediatric patients, on behalf of the GETH-TC.

    BONE MARROW TRANSPLANTATION . : .

    [doi:10.1038/s41409-024-02483-0]

  • Puig N, Agullo Roca C, Sanfeliciano TC, Cedena MT, Martínez-López J, Oriol A, Blanchard MJ, Ríos-Tamayo R, Iñigo Rodríguez B, Sureda A, Lakhwani S, de la Rubia Comos J, Gonzalez-Calle V, Cabañas V, Palomera L, Moraleda JMM, Bargay J, Castro S, Rosiñol L, Bladé J, San-Miguel JF, Lahuerta JJ, Paiva B, Mateos MV.

    Measurable Residual Disease by Mass Spectrometry and Next-Generation Flow to Assess Treatment Response in Myeloma.

    Blood . 144(23): 2432-2438.

    [doi:10.1182/blood.2024024995]

  • Hammoud, Miloud, Dominguez-Ruiz, Maria, Assiri, Imane, Rodrigues, Daniel, Aboussair, Nisrine, Lanza, Val F., Villarrubia, Jesus, Colon, Cristobal, Fdil, Naima, del Castillo, Francisco J..

    Metachromatic Leukodystrophy in Morocco: Identification of Causative Variants by Next-Generation Sequencing (NGS)

    GENES . 15(12): .

    [doi:10.3390/genes15121515]

  • Quinonero, Isabel Rodenas, Marco-Ayala, Javier, Chen-Liang, Tzu-Hua, de la Cruz-vicente, Fatima, Baumann, Tycho, Navarro, Jose-Tomas, Garcia-Sancho, Alejandro Martin, Martin-Santos, Taida, Lopez-Jimenez, Javier, Andreu, Rafael, Parra, Ester, Usas, Andrea, Alonso, David, Fernandez-Gonzalez, Marta, Rumschisky, Pablo Palomo, Frutos, Laura, Navarro, Jose Luis, Alvarez-Perez, Rosa Maria, Sarandeses, Pilar, Cortes, Montserrat, Tamayo, Pilar, Una, Jon, Martinez-Lorca, Alberto, Ruiz, Cristina, Lozano, Maria Luisa, Ortuno, Francisco Jose.

    The Value of Bone Marrow Assessment by FDG PET/CT, Biopsy and Aspirate in the Upfront Evaluation of Mantle Cell Lymphoma: A Nationwide Cohort Study

    Cancers . 16(24): .

    [doi:10.3390/cancers16244189]

  • Santaliestra M, Garrote M, Noya MS, Pérez-Encinas M, Senín A, Pérez-López R, Ferrer-Marín F, Carreño-Tarragona G, Caballero G, Magro E, Vélez P, Cortés Vázquez MÁ, Moretó A, Angona A, Pastor-Galán I, Guerra JM, García Hernández C, Mata MI, Stuckey R, Gómez-Casares MT, Fox L, Cuevas B, García-Gutiérrez V, Triguero A, Arellano-Rodrigo E, Hernández-Boluda JC, Alvarez-Larrán A.

    Prognostic value of response to first-line hydroxyurea according to IPSET stratification in essential thrombocythemia.

    Leukemia . 38(12): 2636-2643.

    [doi:10.1038/s41375-024-02416-2]