Neurodegenerative diseases: pathogenic mechanisms
Search for publications
Only original articles, editorials, guidelines.
-
Díaz-Alonso J, de Salas-Quiroga A, Paraíso-Luna J, García-Rincón D, Garcez PP, Parsons M, Andradas C, Sánchez C, Guillemot F, Guzmán M, Galve-Roperh I.
Loss of Cannabinoid CB1 Receptors Induces Cortical Migration Malformations and Increases Seizure Susceptibility.
CEREBRAL CORTEX . 27(11): 5303-5317. Number of citations: 17
-
Bravo-Ferrer I, Cuartero MI, Zarruk JG, Pradillo JM, Hurtado O, Romera VG, Díaz-Alonso J, García-Segura JM, Guzmán M, Lizasoain I, Galve-Roperh I, Moro MA.
Cannabinoid Type-2 Receptor Drives Neurogenesis and Improves Functional Outcome After Stroke.
Stroke . 48(1): 204-212. Number of citations: 35
-
Hernández-Tiedra S, Fabriàs G, Dávila D, Salanueva ÍJ, Casas J, Montes LR, Antón Z, García-Taboada E, Salazar-Roa M, Lorente M, Nylandsted J, Armstrong J, López-Valero I, McKee CS, Serrano-Puebla A, García-López R, González-Martínez J, Abad JL, Hanada K, Boya P, Goñi F, Guzmán M, Lovat P, Jäättelä M, Alonso A, Velasco G.
Dihydroceramide accumulation mediates cytotoxic autophagy of cancer cells via autolysosome destabilization
Autophagy . 12(11): 2213-2229. Number of citations: 82
-
Bellocchio L, Ruiz-Calvo A, Chiarlone A, Cabanas M, Resel E, Cazalets JR, Blázquez C, Cho YH, Galve-Roperh I, Guzmán M.
Sustained Gq-Protein Signaling Disrupts Striatal Circuits via JNK.
JOURNAL OF NEUROSCIENCE . 36(41): 10611-10624. Number of citations: 9
-
Chiarlone A, Börner C, Martín-Gómez L, Jiménez-González A, García-Concejo A, García-Bermejo ML, Lorente M, Blázquez C, García-Taboada E, de Haro A, Martella E, Höllt V, Rodríguez R, Galve-Roperh I, Kraus J, Guzmán M.
MicroRNA let-7d is a target of cannabinoid CB1 receptor and controls cannabinoid signaling.
Neuropharmacology . 108: 345-352. Number of citations: 17
-
Andradas C, Blasco-Benito S, Castillo-Lluva S, Dillenburg-Pilla P, Diez-Alarcia R, Juanes-García A, García-Taboada E, Hernando-Llorente R, Soriano J, Hamann S, Wenners A, Alkatout I, Klapper W, Rocken C, Bauer M, Arnold N, Quintanilla M, Megías D, Vicente-Manzanares M, Urigüen L, Gutkind JS, Guzmán M, Pérez-Gómez E, Sánchez C.
Activation of the orphan receptor GPR55 by lysophosphatidylinositol promotes metastasis in triple-negative breast cancer.
Oncotarget . 7(30): 47565-47575. Number of citations: 32
-
Díaz-Alonso J, Paraíso-Luna J, Navarrete C, Del Río C, Cantarero I, Palomares B, Aguareles J, Fernández-Ruiz J, Bellido ML, Pollastro F, Appendino G, Calzado MA, Galve-Roperh I, Muñoz E.
VCE-003.2, a novel cannabigerol derivative, enhances neuronal progenitor cell survival and alleviates symptomatology in murine models of Huntington's disease.
SCIENTIFIC REPORTS . 6: 29789-29789. Number of citations: 44
-
López-Sendón Moreno JL, García Caldentey J, Trigo Cubillo P, Ruiz Romero C, García Ribas G, Alonso Arias MA, García de Yébenes MJ, Tolón RM, Galve-Roperh I, Sagredo O, Valdeolivas S, Resel E, Ortega-Gutierrez S, García-Bermejo ML, Fernández Ruiz J, Guzmán M, García de Yébenes Prous J.
A double-blind, randomized, cross-over, placebo-controlled, pilot trial with Sativex in Huntington's disease.
JOURNAL OF NEUROLOGY . 263(7): 1390-1400. Number of citations: 69
-
Velasco G, Sánchez C, Guzmán M.
Anticancer mechanisms of cannabinoids.
Current Oncology . 23(2): 23-32. Number of citations: 128
-
de Salas-Quiroga A, Díaz-Alonso J, García-Rincón D, Remmers F, Vega D, Gómez-Cañas M, Lutz B, Guzmán M, Galve-Roperh I.
Prenatal exposure to cannabinoids evokes long-lasting functional alterations by targeting CB1 receptors on developing cortical neurons
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA . 112(44): 13693-13698. Number of citations: 76
-
Busquets-Garcia A, Desprez T, Metna-Laurent M, Bellocchio L, Marsicano G, Soria-Gomez E.
Dissecting the cannabinergic control of behavior: The where matters
Bioessays . 37(11): 1215-1225. Number of citations: 54
-
Blázquez C, Chiarlone A, Bellocchio L, Resel E, Pruunsild P, García-Rincón D, Sendtner M, Timmusk T, Lutz B, Galve-Roperh I, Guzmán M.
The CB1 cannabinoid receptor signals striatal neuroprotection via a PI3K/Akt/mTORC1/BDNF pathway
CELL DEATH AND DIFFERENTIATION . 22(10): 1618-1629. Number of citations: 86
-
Díaz-Alonso J, Aguado T, de Salas-Quiroga A, Ortega Z, Guzmán M, Galve-Roperh I.
CB1 Cannabinoid Receptor-Dependent Activation of mTORC1/Pax6 Signaling Drives Tbr2 Expression and Basal Progenitor Expansion in the Developing Mouse Cortex
CEREBRAL CORTEX . 25(9): 2395-2408. Number of citations: 16
-
Martín R, Bajo-Grañeras R, Moratalla R, Perea G, Araque A.
Circuit-specific signaling in astrocyte-neuron networks in basal ganglia pathways
Science . 349(6249): 730-734. Number of citations: 174
-
Salazar M, Lorente M, García-Taboada E, Gómez EP, Dávila D, Zúñiga-García P, Flores JM, Rodríguez A, Hegedus Z, Mosén-Ansorena D, Aransay AM, Hernández-Tiedra S, López-Valero I, Quintanilla M, Sánchez C, Iovanna JL, Dusetti N, Guzmán M, Francis SE, Carracedo A, Kiss-Toth E, Velasco G.
TRIB3 suppresses tumorigenesis by controlling mTORC2/AKT/FOXO signaling.
Molecular & cellular oncology . 2(3): . Number of citations: 16
-
Sanchez D, Bajo-Grañeras R, Del Caño-Espinel M, Garcia-Centeno R, Garcia-Mateo N, Pascua-Maestro R, Ganfornina MD.
Aging without Apolipoprotein D: Molecular and cellular modifications in the hippocampus and cortex
EXPERIMENTAL GERONTOLOGY . 67: 19-47. Number of citations: 24
-
Stern CA, Gazarini L, Vanvossen AC, Zuardi AW, Galve-Roperh I, Guimaraes FS, Takahashi RN, Bertoglio LJ.
Delta(9)-Tetrahydrocannabinol alone and combined with cannabidiol mitigate fear memory through reconsolidation disruption
EUROPEAN NEUROPSYCHOPHARMACOLOGY . 25(6): 958-965. Number of citations: 42
-
Abrams DI, Guzman M.
Cannabis in Cancer Care
CLINICAL PHARMACOLOGY & THERAPEUTICS . 97(6): 575-586. Number of citations: 111