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Neurodegenerative diseases: pathogenic mechanisms

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  • Pérez-Gómez E, Andradas C, Blasco-Benito S, Caffarel MM, García-Taboada E, Villa-Morales M, Moreno E, Hamann S, Martín-Villar E, Flores JM, Wenners A, Alkatout I, Klapper W, Röcken C, Bronsert P, Stickeler E, Staebler A, Bauer M, Arnold N, Soriano J, Pérez-Martínez M, Megías D, Moreno-Bueno G, Ortega-Gutiérrez S, Artola M, Vázquez-Villa H, Quintanilla M, Fernández-Piqueras J, Canela EI, McCormick PJ, Guzmán M, Sánchez C.

    Role of Cannabinoid Receptor CB2 in HER2 Pro-oncogenic Signaling in Breast Cancer

    JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE . 107(6): . Number of citations: 67

    [doi:10.1093/jnci/djv077]

  • Oddi D, Subashi E, Middei S, Bellocchio L, Lemaire-Mayo V, Guzmán M, Crusio WE, D'Amato FR, Pietropaolo S.

    Early Social Enrichment Rescues Adult Behavioral and Brain Abnormalities in a Mouse Model of Fragile X Syndrome

    NEUROPSYCHOPHARMACOLOGY . 40(5): 1113-1122. Number of citations: 62

    [doi:10.1038/npp.2014.291]

  • Garcez PP, Diaz-Alonso J, Crespo-Enriquez I, Castro D, Bell D, Guillemot F.

    Cenpj/CPAP regulates progenitor divisions and neuronal migration in the cerebral cortex downstream of Ascl1

    NATURE COMMUNICATIONS . 6: 6474-6474. Number of citations: 37

    [doi:10.1038/ncomms7474]

  • Cardinal P, Bellocchio L, Guzmán-Quevedo O, André C, Clark S, Elie M, Leste-Lasserre T, Gonzales D, Cannich A, Marsicano G, Cota D.

    Cannabinoid Type 1 (CB1) Receptors on Sim1-Expressing Neurons Regulate Energy Expenditure in Male Mice

    Endocrinology . 156(2): 411-418. Number of citations: 31

    [doi:10.1210/en.2014-1437]

  • Pietropaolo S, Bellocchio L, Ruiz-Calvo A, Cabanas M, Du Z, Guzmán M, Garret M, Cho YH.

    Chronic cannabinoid receptor stimulation selectively prevents motor impairments in a mouse model of Huntington's disease

    Neuropharmacology . 89: 368-374. Number of citations: 21

    [doi:10.1016/j.neuropharm.2014.07.021]

  • Velasco G, Sánchez C, Guzmán M.

    Endocannabinoids and Cancer.

    Handbook of experimental pharmacology . 231: 449-472.

    [doi:10.1007/978-3-319-20825-1_16]

  • Crespo-Sanjuán J, Calvo-Nieves MD, Aguirre-Gervás B, Herreros-Rodríguez J, Velayos-Jiménez B, Castro-Alija MJ, Muñoz-Moreno MF, Sánchez D, Zamora-González N, Bajo-Grañeras R, García-Centeno RM, Largo Cabrerizo ME, Bustamante MR, Garrote-Adrados JA.

    Early Detection of High Oxidative Activity in Patients With Adenomatous Intestinal Polyps and Colorectal Adenocarcinoma: Myeloperoxidase and Oxidized Low-Density Lipoprotein in Serum as New Markers of Oxidative Stress in Colorectal Cancer

    Labmedicine . 46(2): 123-135. Number of citations: 18

    [doi:10.1309/LMZJJU6BC86WUDHW]

  • Salazar M, Lorente M, García-Taboada E, Pérez Gómez E, Dávila D, Zúñiga-García P, María Flores J, Rodríguez A, Hegedus Z, Mosén-Ansorena D, Aransay AM, Hernández-Tiedra S, López-Valero I, Quintanilla M, Sánchez C, Iovanna JL, Dusetti N, Guzmán M, Francis SE, Carracedo A, Kiss-Toth E, Velasco G.

    Loss of Tribbles pseudokinase-3 promotes Akt-driven tumorigenesis via FOXO inactivation

    CELL DEATH AND DIFFERENTIATION . 22(1, SI): 131-144. Number of citations: 61

    [doi:10.1038/cdd.2014.133]

  • Vicario-de-la-Torre M, Benítez-del-Castillo JM, Vico E, Guzmán M, de-Las-Heras B, Herrero-Vanrell R, Molina-Martínez IT.

    Design and Characterization of an Ocular Topical Liposomal Preparation to Replenish the Lipids of the Tear Film

    INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE . 55(12): 7839-7847. Number of citations: 38

    [doi:10.1167/iovs.14-14700]

  • Maccarrone M, Guzmán M, Mackie K, Doherty P, Harkany T.

    Programming of neural cells by (endo) cannabinoids: from physiological rules to emerging therapies

    NATURE REVIEWS NEUROSCIENCE . 15(12): 786-801. Number of citations: 180

    [doi:10.1038/nrn3846]

  • Soria-Gomez E, Bellocchio L, Marsicano G.

    New insights on food intake control by olfactory processes: The emerging role of the endocannabinoid system

    MOLECULAR AND CELLULAR ENDOCRINOLOGY . 397(1-2, SI): 59-66. Number of citations: 27

    [doi:10.1016/j.mce.2014.09.023]

  • Cardinal P, André C, Quarta C, Bellocchio L, Clark S, Elie M, Leste-Lasserre T, Maitre M, Gonzales D, Cannich A, Pagotto U, Marsicano G, Cota D.

    CB1 cannabinoid receptor in SF1-expressing neurons of the ventromedial hypothalamus determines metabolic responses to diet and leptin

    Molecular metabolism . 3(7): 705-716. Number of citations: 54

    [doi:10.1016/j.molmet.2014.07.004]

  • Guzmán M, Sabbione F, Gabelloni ML, Vanzulli S, Trevani AS, Giordano MN, Galletti JG.

    Restoring Conjunctival Tolerance by Topical Nuclear Factor-kappa B Inhibitors Reduces Preservative-Facilitated Allergic Conjunctivitis in Mice

    INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE . 55(9): 6116-6126. Number of citations: 27

    [doi:10.1167/iovs.14-14075]

  • Moreno E, Andradas C, Medrano M, Caffarel MM, Pérez-Gómez E, Blasco-Benito S, Gómez-Cañas M, Pazos MR, Irving AJ, Lluís C, Canela EI, Fernández-Ruiz J, Guzmán M, McCormick PJ, Sánchez C.

    Targeting CB2-GPR55 Receptor Heteromers Modulates Cancer Cell Signaling

    JOURNAL OF BIOLOGICAL CHEMISTRY . 289(32): 21960-21972. Number of citations: 71

    [doi:10.1074/jbc.M114.561761]

  • Chiarlone A, Bellocchio L, Blázquez C, Resel E, Soria-Gómez E, Cannich A, Ferrero JJ, Sagredo O, Benito C, Romero J, Sánchez-Prieto J, Lutz B, Fernández-Ruiz J, Galve-Roperh I, Guzmán M.

    A restricted population of CB1 cannabinoid receptors with neuroprotective activity

    PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA . 111(22): 8257-8262. Number of citations: 109

    [doi:10.1073/pnas.1400988111]

  • Soria-Gómez E, Massa F, Bellocchio L, Rueda-Orozco PE, Ciofi P, Cota D, Oliet SH, Prospéro-García O, Marsicano G.

    CANNABINOID TYPE-1 RECEPTORS IN THE PARAVENTRICULAR NUCLEUS OF THE HYPOTHALAMUS INHIBIT STIMULATED FOOD INTAKE

    Neuroscience . 263: 46-53. Number of citations: 23

    [doi:10.1016/j.neuroscience.2014.01.005]

  • Soria-Gómez E, Bellocchio L, Reguero L, Lepousez G, Martin C, Bendahmane M, Ruehle S, Remmers F, Desprez T, Matias I, Wiesner T, Cannich A, Nissant A, Wadleigh A, Pape HC, Chiarlone AP, Quarta C, Verrier D, Vincent P, Massa F, Lutz B, Guzmán M, Gurden H, Ferreira G, Lledo PM, Grandes P, Marsicano G.

    The endocannabinoid system controls food intake via olfactory processes

    NATURE NEUROSCIENCE . 17(3): 407-415. Number of citations: 157

    [doi:10.1038/nn.3647]

  • Vallée M, Vitiello S, Bellocchio L, Hébert-Chatelain E, Monlezun S, Martin-Garcia E, Kasanetz F, Baillie GL, Panin F, Cathala A, Roullot-Lacarrière V, Fabre S, Hurst DP, Lynch DL, Shore DM, Deroche-Gamonet V, Spampinato U, Revest JM, Maldonado R, Reggio PH, Ross RA, Marsicano G, Piazza PV.

    Pregnenolone Can Protect the Brain from Cannabis Intoxication

    Science . 343(6166): 94-98. Number of citations: 181

    [doi:10.1126/science.1243985]