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Biomarkers and Personalized Approach to Cancer Group (BioPAC)

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  • López-López C, de Castro EM, Montes AF, Orozco EJ, Peraita SL, Vera R, Cerdá P, Calvo M, Paredes BG, de Mena ML, La Casta A, Gallego J, Adeva J, Cano JMC, Ruiz-Casado A, Vidal-Tocino R, García-García T, Pazo-Cid R, Garrote MR, Sastre J.

    Real-world management and outcomes of patients with hepatocellular carcinoma treated with systemic therapy in Spain: a patient cohort from the RETUD gastrointestinal registry

    CLINICAL & TRANSLATIONAL ONCOLOGY . : .

    [doi:10.1007/s12094-025-04010-z]

  • Earl J, Kataki A, Canzian F, Costello E, Campa D, Greenhalf W.

    Targeting pancreatic cancer screening by identification of pathogenic variants of BRCA2/ BRCA1 in healthy individuals who have no known family history of pancreatic cancer: The arguments for and against

    Seminars in cancer biology . 113: 1-8.

    [doi:10.1016/j.semcancer.2025.05.001]

  • He J, Alhamwe BA, Sabroso S, Carrato A, Hidalgo M, Molero X, Iglesias M, Perea J, Farré A, Tardón A, Dominguez-Muñoz E, Barberà V, Muñoz-Bellvís L, Löhr M, Greenhalf W, O'Rorke M, Gress T, Crnogorac-Jurcevic T, Gayà A, Langtry A, Kleeff J, Lawlor R, Real FX, Renz H, Malats N.

    Low type-2 immune effectors modulate atopic diseases' protective role in pancreatic cancer risk

    INTERNATIONAL JOURNAL OF CANCER . 157(3): 468-479.

    [doi:10.1002/ijc.35397]

  • Alsina M, Villacampa G, de Andrea C, Vivancos A, Ponz-Sarvise M, Arrazubi V, Jimenez-Fonseca P, Diez M, Sanz-Garcia E, Martínez E, Guardeño R, Calvo M, Bugés C, Longo F, Navarro V, García-Galea E, Gros A, Ochoa MC, Lopez-Janeiro A, Sanchez-Gregorio S, Herrero C, Labiano I, Vila-Casadesús M, López D, Alexandru R, Muñoz S, Tabernero J, Melero I.

    A Phase II Study of Perioperative Avelumab plus Chemotherapy for Patients with Resectable Gastric Cancer or Gastroesophageal Junction Cancer - The MONEO Study

    CLINICAL CANCER RESEARCH . 31(14): 2890-2898. Number of citations: 3

    [doi:10.1158/1078-0432.CCR-25-0369]

  • Villacampa A, Shamoon L, Valencia I, Morales C, Figueiras S, de la Cuesta F, Sánchez-Niño D, Díaz-Araya G, Sánchez-Pérez I, Lorenzo Ó, Sánchez-Ferrer CF, Peiró C.

    SARS-CoV-2 S Protein Reduces Cytoprotective Defenses and Promotes Human Endothelial Cell Senescence

    AGING AND DISEASE . 16(3): 1626-1638. Number of citations: 8

    [doi:10.14336/AD.2024.0405]

  • Raposeiras-Roubin S, Amat-Santos IJ, Rossello X, González Ferreiro R, González Bermúdez I, Lopez Otero D, Nombela-Franco L, Gheorghe L, Diez JL, Baladrón Zorita C, Baz JA, Muñoz García AJ, Vilalta V, Ojeda-Pineda S, de la Torre Hernández JM, Cordoba Soriano JG, Regueiro A, Bordes Siscar P, Salgado Fernández J, Garcia Del Blanco B, Martín-Reyes R, Romaguera R, Moris C, García Blas S, Franco-Peláez JA, Cruz-González I, Arzamendi D, Romero Rodríguez N, Díez-Del Hoyo F, Camacho Freire S, Bosa Ojeda F, Astorga Burgo JC, Molina Navarro E, Caballero Borrego J, Ruiz Quevedo V, Sánchez-Recalde Á, Peral Disdier V, Alegría-Barrero E, Torres-Llergo J, Feltes G, Fernández Díaz JA, Cuellas C, Jiménez Britez G, Sánchez-Rubio Lezcano J, Barreiro-Pardal C, Núñez-Gil I, Abu-Assi E, Iñiguez-Romo A, Fuster V, Ibáñez B.

    Dapagliflozin in Patients Undergoing Transcatheter Aortic-Valve Implantation

    NEW ENGLAND JOURNAL OF MEDICINE . 392(14): 1396-1405. Number of citations: 41

    [doi:10.1056/NEJMoa2500366]

  • Macarulla, T., Munoz, A., de Castro, E. Martinez, Castillo, A., Cano, M. T., Castet, F., Vidal, R., Ferrandez, A., Ghanem, I., Ales, I., Vera, R., Lobo, M., Adeva, J., Melian, M., Gallego, I., Laquente, B., Montes, A. Fernandez, Peinado, P., Paredes, B. Garcia, Pazo, R., Escobar, I. Garcia, de Mena, I. Ruiz, Carrato, A., Aranda, E..

    Real-world management and outcome of patients with pancreatic adenocarcinoma. Results of the Spanish RETUD gastrointestinal registry

    Esmo Real World Data And Digital Oncology . 7: . Number of citations: 1

    [doi:10.1016/j.esmorw.2025.100116]

  • Tost J, Ak-Aksoy S, Campa D, Corradi C, Farinella R, Ibáñez-Costa A, Dubrot J, Earl J, Melian EB, Kataki A, Kolnikova G, Madjarov G, Chaushevska M, Strnadel J, Tanic M, Tomas M, Dubovan P, Urbanova M, Buocikova V, Smolkova B.

    Leveraging epigenetic alterations in pancreatic ductal adenocarcinoma for clinical applications

    Seminars in cancer biology . 109: 101-124. Number of citations: 1

    [doi:10.1016/j.semcancer.2025.01.003]

  • Bakirdögen D, Görgülü K, Xin J, Alcalá S, Ruiz-Cañas L, Frank K, Wu N, Diakopoulos KN, Dai C, Öztürk H, Demircioglu D, Peschke K, Ranjan R, Fusco F, Martinez-Useros J, Fernandez-Aceñero MJ, Chhabra NF, López-Gil JC, Ai J, Ruess DA, Kaya-Aksoy E, Steiger K, Schmidt F, Kohlmann L, Berninger A, Schmid RM, Reichert M, Adli M, Lesina M, Sainz B Jr, Algül H.

    c-Rel drives pancreatic cancer metastasis through Fibronectin-Integrin signaling-induced isolation stress resistance and EMT activation.

    Biorxiv : The Preprint Server For Biology . : .

    [doi:10.1101/2025.01.29.635445]

  • Marabelle A, O'Malley DM, Hendifar AE, Ascierto PA, Motola-Kuba D, Penel N, Cassier PA, Bariani G, De Jesus-Acosta A, Doi T, Longo F, Miller WH Jr, Oh DY, Gottfried M, Yao L, Jin F, Gozman A, Maio M.

    Pembrolizumab in microsatellite-instability-high and mismatch-repair-deficient advanced solid tumors: updated results of the KEYNOTE-158 trial

    Nature Cancer . 6(2): 253-258. Number of citations: 9

    [doi:10.1038/s43018-024-00894-y]

  • Vaz-Salgado MA, Sepulveda JM, Earl J, Gutierrez J, Ruano Y, Pian H, Cantero D, Segura-Collar B, Gargini R, Hernández-Laín A.

    Oligodendrogliomas, cyclin pathway after the introduction of the molecular 2021 World Health Organization (WHO) criteria

    Brain Communications . 7(5): .

    [doi:10.1093/braincomms/fcaf380]

  • Vaz-Salgado MA, Sepulveda JM, Earl J, Gutierrez J, Ruano Y, Pian H, Cantero D, Hernández-Lain A.

    Oligodendrogliomas: findings after classifying the same cohort using pre- and post-World Health Organization (WHO) 2021 criteria

    Brain Communications . 7(4): .

    [doi:10.1093/braincomms/fcaf265]

  • Hewitt E, Bouche G, Alencar AC, Bigelsen SJ, Radu R, Stoyanova-Beninska V, Carrato A, Valsecchi F, Soler Cantón A, van der Meer HG, García Bermejo ML, Budillon A, Cardone L, Rooman I, Platteeuw H, Baijet J, Fuchs C.

    Drug Repurposing in Pancreatic Cancer: A Multi-Stakeholder Perspective to Improve Treatment Options for Pancreatic Cancer Patients

    Cancer Management And Research . 17: 429-440. Number of citations: 1

    [doi:10.2147/CMAR.S483151]

  • Niedra H, Rogoza O, Saksis R, Peculis R, Halilova A, Gerina A, Vilisova S, Senterjakova N, Pukitis A, Ruz-Caracuel I, Earl J, Kolnikova G, Dubovan P, Tomas M, Makovicky P, Urbanova M, Smolkova B, Koniaris E, Aggelioudaki I, Kataki A, Rovite V.

    Transcriptomic profiling of pancreatic neuroendocrine tumors: dysregulation of WNT, MAPK, PI3K, neddylation pathways and potential non-invasive biomarkers

    Plos One . 20(6): .

    [doi:10.1371/journal.pone.0325672]

  • Hughes BGM, Guminski A, Bowyer S, Migden MR, Schmults CD, Khushalani NI, Chang ALS, Grob JJ, Lewis KD, Ansstas G, Day F, Ladwa R, Stein BN, Muñoz Couselo E, Meier F, Hauschild A, Schadendorf D, Basset-Seguin N, Modi B, Dalac-Rat S, Dunn LA, Flatz L, Mortier L, Guégan S, Heinzerling LM, Mehnert JM, Trabelsi S, Soria-Rivas A, Stratigos AJ, Ulrich C, Wong DJ, Beylot-Barry M, Bossi P, Bugés Sánchez C, Chandra S, Robert C, Russell JS, Silk AW, Booth J, Yoo SY, Seebach F, Lowy I, Fury MG, Rischin D.

    A phase 2 open-label study of cemiplimab in patients with advanced cutaneous squamous cell carcinoma (EMPOWER-CSCC-1): Final long-term analysis of Groups 1, 2, and 3, and primary analysis of fixed-dose treatment Group 6.

    JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY . 92(1): 68-77.

    [doi:10.1016/j.jaad.2024.06.108]

  • Candel FJ, Salavert M, Cantón R, Del Pozo JL, Galán-Sánchez F, Navarro D, Rodríguez A, Rodríguez JC, Rodríguez-Aguirregabiria M, Suberviola B, Zaragoza R.

    The role of rapid multiplex molecular syndromic panels in the clinical management of infections in critically ill patients: an experts-opinion document.

    CRITICAL CARE . 28(1): 440-440.

    [doi:10.1186/s13054-024-05224-3]

  • Aksoy SA, Earl J, Grahovac J, Karakas D, Lencioni G, Sigirli S, Bijlsma MF.

    Organoids, tissue slices and organotypic cultures: Advancing our understanding of pancreatic ductal adenocarcinoma through in vitro and ex vivo models.

    Seminars in cancer biology . 109: 10-24.

    [doi:10.1016/j.semcancer.2024.12.003]

  • Palencia-Campos A, Ruiz-Cañas L, Abal-Sanisidro M, López-Gil JC, Batres-Ramos S, Saraiva SM, Yagüe B, Navarro D, Alcalá S, Rubiolo JA, Bidan N, Sánchez L, Mura S, Hermann PC, de la Fuente M, Sainz B.

    Reprogramming tumor-associated macrophages with lipid nanosystems reduces PDAC tumor burden and liver metastasis.

    JOURNAL OF NANOBIOTECHNOLOGY . 22(1): 795-795.

    [doi:10.1186/s12951-024-03010-5]