Cancer stem cells and fibroinflammatory microenvironment

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  • Alcalá S, Mayoral-Varo V, Ruiz-Cañas L, López-Gil JC, Heeschen C, Martín-Pérez J, Sainz B Jr.

    Correction: Alcalá, S., et al. Targeting SRC Kinase Signaling in Pancreatic Cancer Stem Cells. Int. J. Mol. Sci. 2020, 21, 7437.

    INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES . 21(23): .

    [doi:10.3390/ijms21239215]

  • Friederich MW, Timal S, Powell CA, Dallabona C, Kurolap A, Palacios-Zambrano S, Bratkovic D, Derks TGJ, Bick D, Bouman K, Chatfield KC, Damouny-Naoum N, Dishop MK, Falik-Zaccai TC, Fares F, Fedida A, Ferrero I, Gallagher RC, Garesse R, Gilberti M, González C, Gowan K, Habib C, Halligan RK, Kalfon L, Knight K, Lefeber D, Mamblona L, Mandel H, Mory A, Ottoson J, Paperna T, Pruijn GJM, Rebelo-Guiomar PF, Saada A, Sainz B, Salvemini H, Schoots MH, Smeitink JA, Szukszto MJ, Ter Horst HJ, van den Brandt F, van Spronsen FJ, Veltman JA, Wartchow E, Wintjes LT, Zohar Y, Fernández-Moreno MA, Baris HN, Donnini C, Minczuk M, Rodenburg RJ, Van Hove JLK.

    Pathogenic variants in glutamyl-tRNA Gln amidotransferase subunits cause a lethal mitochondrial cardiomyopathy disorder.

    NATURE COMMUNICATIONS . 9(1): 4065-4065. Number of citations: 12

    [doi:10.1038/s41467-018-06250-w]

  • Martinelli P, Carrillo-de Santa Pau E, Cox T, Sainz B, Dusetti N, Greenhalf W, Rinaldi L, Costello E, Ghaneh P, Malats N, Büchler M, Pajic M, Biankin AV, Iovanna J, Neoptolemos J, Real FX.

    GATA6 regulates EMT and tumour dissemination, and is a marker of response to adjuvant chemotherapy in pancreatic cancer.

    Gut . : .

    [doi:10.1136/gutjnl-2015-311256]

  • Hohwieler M, Illing A, Hermann PC, Mayer T, Stockmann M, Perkhofer L, Eiseler T, Antony JS, Müller M, Renz S, Kuo CC, Lin Q, Sendler M, Breunig M, Kleiderman SM, Lechel A, Zenker M, Leichsenring M, Rosendahl J, Zenke M, Sainz B, Mayerle J, Costa IG, Seufferlein T, Kormann M, Wagner M, Liebau S, Kleger A.

    Human pluripotent stem cell-derived acinar/ductal organoids generate human pancreas upon orthotopic transplantation and allow disease modelling.

    Gut . : .

    [doi:10.1136/gutjnl-2016-312423]

  • Cioffi M, Vallespinos-Serrano M, Trabulo SM, Fernandez-Marcos PJ, Firment AN, Vazquez BN, Vieira CR, Mulero F, Camara JA, Cronin UP, Perez M, Soriano J, G Galvez B, Castells-Garcia A, Haage V, Raj D, Megias D, Hahn S, Serrano L, Moon A, Aicher A, Heeschen C.

    MiR-93 Controls Adiposity via Inhibition of Sirt7 and Tbx3

    CELL REPORTS . 12(10): 1594-1605. Number of citations: 59

    [doi:10.1016/j.celrep.2015.08.006]

  • Sainz B, Carron E, Vallespinós M, Machado HL.

    Cancer Stem Cells and Macrophages: Implications in Tumor Biology and Therapeutic Strategies

    MEDIATORS OF INFLAMMATION . 2016: 9012369-9012369. Number of citations: 43

    [doi:10.1155/2016/9012369]

  • Sancho P, Alcala S, Usachov V, Hermann PC, Sainz B.

    The ever-changing landscape of pancreatic cancer stem cells.

    Pancreatology . 16(4): 489-496. Number of citations: 10

    [doi:10.1016/j.pan.2016.04.004]

  • Zagorac S, Alcala S, Fernandez Bayon G, Bou Kheir T, Schoenhals M, González-Neira A, Fernandez Fraga M, Aicher A, Heeschen C, Sainz B.

    DNMT1 Inhibition Reprograms Pancreatic Cancer Stem Cells via Upregulation of the miR-17-92 Cluster

    CANCER RESEARCH . 76(15): 4546-4558. Number of citations: 51

    [doi:10.1158/0008-5472.CAN-15-3268]

  • López-Gómez M, Casado E, Muñoz M, Alcalá S, Moreno-Rubio J, D'Errico G, Jiménez-Gordo AM, Salinas S, Sainz B.

    Current evidence for cancer stem cells in gastrointestinal tumors and future research perspectives.

    CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY . 107: 54-71. Number of citations: 3

    [doi:10.1016/j.critrevonc.2016.08.006]

  • da Silva IL, Montero-Montero L, Martín-Villar E, Martin-Pérez J, Sainz B, Renart J, Toscano Simões R, Soares Veloso É, Salviano Teixeira C, de Oliveira MC, Ferreira E, Quintanilla M.

    Reduced expression of the murine HLA-G homolog Qa-2 is associated with malignancy, epithelial-mesenchymal transition and stemness in breast cancer cells.

    SCIENTIFIC REPORTS . 7(1): 6276-6276. Number of citations: 5

    [doi:10.1038/s41598-017-06528-x]

  • D'Errico G, Machado HL, Sainz B.

    A current perspective on cancer immune therapy: step-by-step approach to constructing the magic bullet.

    Clinical And Translational Medicine . 6(1): 3-3. Number of citations: 36

    [doi:10.1186/s40169-016-0130-5]

  • Valle S, Martin-Hijano L, Alcalá S, Alonso-Nocelo M, Sainz B.

    The Ever-Evolving Concept of the Cancer Stem Cell in Pancreatic Cancer.

    Cancers . 10(2): 33. Number of citations: 43

    [doi:10.3390/cancers10020033]

  • Djurec M, Graña O, Lee A, Troulé K, Espinet E, Cabras L, Navas C, Blasco MT, Martín-Díaz L, Burdiel M, Li J, Liu Z, Vallespinós M, Sanchez-Bueno F, Sprick MR, Trumpp A, Sainz B, Al-Shahrour F, Rabadan R, Guerra C, Barbacid M.

    Saa3 is a key mediator of the protumorigenic properties of cancer-associated fibroblasts in pancreatic tumors.

    PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA . 115(6): 1147-1156. Number of citations: 45

    [doi:10.1073/pnas.1717802115]

  • González I, Earl J, Fernández LJ, Sainz B, Pinto A, Monge R, Alcalá S, Castillejo A, Soto JL, Carrato A.

    A Label Free Disposable Device for Rapid Isolation of Rare Tumor Cells from Blood by Ultrasounds.

    MICROMACHINES . 9(3): 129. Number of citations: 8

    [doi:10.3390/mi9030129]

  • Alguacil-Núñez C, Ferrer-Ortiz I, García-Verdú E, López-Pirez P, Llorente-Cortijo IM, Sainz B.

    Current perspectives on the crosstalk between lung cancer stem cells and cancer-associated fibroblasts.

    CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY . 125: 102-110. Number of citations: 13

    [doi:10.1016/j.critrevonc.2018.02.015]

  • Zagorac, Sladjana, Garcia-Bermejo, Laura, Sainz, Bruno, Jr..

    The Epigenetic Landscape of Pancreatic Cancer Stem Cells

    Epigenomes . 2(2): 10. Number of citations: 2

    [doi:10.3390/epigenomes2020010]

  • Hermann PC, Sainz B.

    Pancreatic cancer stem cells: A state or an entity?

    Seminars in cancer biology . 53: 223-231. Number of citations: 25

    [doi:10.1016/j.semcancer.2018.08.007]

  • Valle S, Alcala S, Martin-Hijano L, Cabezas-Sainz P, Navarro D, Munoz ER, Yuste L, Tiwary K, Walter K, Ruiz-Canas L, Alonso-Nocelo M, Rubiolo JA, Gonzalez-Arnay E, Heeschen C, Garcia-Bermejo L, Hermann PC, Sanchez L, Sancho P, Fernandez-Moreno MA, Sainz B Jr.

    Exploiting oxidative phosphorylation to promote the stem and immunoevasive properties of pancreatic cancer stem cells.

    NATURE COMMUNICATIONS . 11(1): 5265-5265.

    [doi:10.1038/s41467-020-18954-z]