Cancer stem cells and fibroinflammatory microenvironment

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  • Valle S, Alcala S, Martin-Hijano L, Cabezas-Sainz P, Navarro D, Munoz ER, Yuste L, Tiwary K, Walter K, Ruiz-Canas L, Alonso-Nocelo M, Rubiolo JA, Gonzalez-Arnay E, Heeschen C, Garcia-Bermejo L, Hermann PC, Sanchez L, Sancho P, Fernandez-Moreno MA, Sainz B Jr.

    Exploiting oxidative phosphorylation to promote the stem and immunoevasive properties of pancreatic cancer stem cells.

    NATURE COMMUNICATIONS . 11(1): 5265-5265.

    [doi:10.1038/s41467-020-18954-z]

  • Alcala S, Mayoral-Varo V, Ruiz-Canas L, Lopez-Gil JC, Heeschen C, Martin-Perez J, Sainz B Jr.

    Targeting SRC Kinase Signaling in Pancreatic Cancer Stem Cells.

    INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES . 21(20): .

    [doi:10.3390/ijms21207437]

  • Cabezas-Sainz P, Pensado-Lopez A, Sainz B Jr, Sanchez L.

    Modeling Cancer Using Zebrafish Xenografts: Drawbacks for Mimicking the Human Microenvironment.

    Cells . 9(9): .

    [doi:10.3390/cells9091978]

  • Pajuelo-Lozano N, Alcalá S, Sainz B, Perona R, Sanchez-Perez I.

    Targeting MAD2 modulates stemness and tumorigenesis in human Gastric Cancer cell lines.

    THERANOSTICS . 10(21): 9601-9618.

    [doi:10.7150/thno.49270]

  • Cash TP, Alcalá S, Rico-Ferreira MDR, Hernández-Encinas E, García J, Albarrán MI, Valle S, Muñoz J, Martínez-González S, Blanco-Aparicio C, Pastor J, Serrano M, Sainz B.

    Induction of Lysosome Membrane Permeabilization as a Therapeutic Strategy to Target Pancreatic Cancer Stem Cells.

    Cancers . 12(7): .

    [doi:10.3390/cancers12071790]

  • Frappart PO, Walter K, Gout J, Beutel AK, Morawe M, Arnold F, Breunig M, Barth TF, Marienfeld R, Schulte L, Ettrich T, Hackert T, Svinarenko M, Rösler R, Wiese S, Wiese H, Perkhofer L, Müller M, Lechel A, Sainz B, Hermann PC, Seufferlein T, Kleger A.

    Pancreatic cancer-derived organoids - a disease modeling tool to predict drug response.

    UNITED EUROPEAN GASTROENTEROLOGY JOURNAL . 8(5): 594-606. Number of citations: 6

    [doi:10.1177/2050640620905183]

  • Alcalá S, Sancho P, Martinelli P, Navarro D, Pedrero C, Martín-Hijano L, Valle S, Earl J, Rodríguez-Serrano M, Ruiz-Cañas L, Rojas K, Carrato A, García-Bermejo L, Fernández-Moreno MÁ, Hermann PC, Sainz B.

    ISG15 and ISGylation is required for pancreatic cancer stem cell mitophagy and metabolic plasticity.

    NATURE COMMUNICATIONS . 11(1): 2682-2682.

    [doi:10.1038/s41467-020-16395-2]

  • Lerma L, Muñoz AL, García Utrilla R, Sainz B, Lim F, Tabarés E, Gómez-Sebastián S.

    Partial complementation between the immediate early proteins ICP4 of herpes simplex virus type 1 and IE180 of pseudorabies virus.

    VIRUS RESEARCH . 279: 197896-197896.

    [doi:10.1016/j.virusres.2020.197896]

  • Martin-Hijano L, Sainz B.

    The Interactions Between Cancer Stem Cells and the Innate Interferon Signaling Pathway.

    Frontiers in immunology . 11: 526-526.

    [doi:10.3389/fimmu.2020.00526]

  • Schulte LA, López-Gil JC, Sainz B, Hermann PC.

    The Cancer Stem Cell in Hepatocellular Carcinoma.

    Cancers . 12(3): . Number of citations: 2

    [doi:10.3390/cancers12030684]

  • Rodriguez-Aznar E, Wiesmüller L, Sainz B, Hermann PC.

    EMT and Stemness-Key Players in Pancreatic Cancer Stem Cells.

    Cancers . 11(8): 1136. Number of citations: 10

    [doi:10.3390/cancers11081136]

  • D'Errico G, Alonso-Nocelo M, Vallespinos M, Hermann PC, Alcalá S, García CP, Martin-Hijano L, Valle S, Earl J, Cassiano C, Lombardia L, Feliu J, Monti MC, Seufferlein T, García-Bermejo L, Martinelli P, Carrato A, Sainz B.

    Tumor-associated macrophage-secreted 14-3-3? signals via AXL to promote pancreatic cancer chemoresistance.

    Oncogene . 38(27): 5469-5485. Number of citations: 13

    [doi:10.1038/s41388-019-0803-9]

  • Walter K, Tiwary K, Trajkovic-Arsic M, Hidalgo-Sastre A, Dierichs L, Liffers ST, Gu J, Gout J, Schulte LA, Münch J, Seufferlein T, Sainz B, Siveke JT, Rodriguez-Aznar E, Hermann PC.

    MEK Inhibition Targets Cancer Stem Cells and Impedes Migration of Pancreatic Cancer Cells In Vitro and In Vivo .

    STEM CELLS INTERNATIONAL . 2019: 8475389-8475389. Number of citations: 2

    [doi:10.1155/2019/8475389]

  • Alcalá S, Martinelli P, Hermann PC, Heeschen C, Sainz B.

    The Anthrax Toxin Receptor 1 (ANTXR1) Is Enriched in Pancreatic Cancer Stem Cells Derived from Primary Tumor Cultures.

    STEM CELLS INTERNATIONAL . 2019: 1378639-1378639. Number of citations: 1

    [doi:10.1155/2019/1378639]

  • Blasco MT, Navas C, Martín-Serrano G, Graña-Castro O, Lechuga CG, Martín-Díaz L, Djurec M, Li J, Morales-Cacho L, Esteban-Burgos L, Perales-Patón J, Bousquet-Mur E, Castellano E, Jacob HKC, Cabras L, Musteanu M, Drosten M, Ortega S, Mulero F, Sainz B, Dusetti N, Iovanna J, Sánchez-Bueno F, Hidalgo M, Khiabanian H, Rabadán R, Al-Shahrour F, Guerra C, Barbacid M.

    Complete Regression of Advanced Pancreatic Ductal Adenocarcinomas upon Combined Inhibition of EGFR and C-RAF.

    Cancer Cell . 35(4): 573. Number of citations: 15

    [doi:10.1016/j.ccell.2019.03.002]

  • Alcalá S, Sainz B.

    The dark side of radiotherapy-induced cell death in cancer.

    EBioMedicine . 40: 7-8. Number of citations: 1

    [doi:10.1016/j.ebiom.2019.01.047]

  • Hermann PC, Sainz B.

    Pancreatic cancer stem cells: A state or an entity?

    Seminars in cancer biology . 53: 223-231. Number of citations: 22

    [doi:10.1016/j.semcancer.2018.08.007]

  • Friederich MW, Timal S, Powell CA, Dallabona C, Kurolap A, Palacios-Zambrano S, Bratkovic D, Derks TGJ, Bick D, Bouman K, Chatfield KC, Damouny-Naoum N, Dishop MK, Falik-Zaccai TC, Fares F, Fedida A, Ferrero I, Gallagher RC, Garesse R, Gilberti M, González C, Gowan K, Habib C, Halligan RK, Kalfon L, Knight K, Lefeber D, Mamblona L, Mandel H, Mory A, Ottoson J, Paperna T, Pruijn GJM, Rebelo-Guiomar PF, Saada A, Sainz B, Salvemini H, Schoots MH, Smeitink JA, Szukszto MJ, Ter Horst HJ, van den Brandt F, van Spronsen FJ, Veltman JA, Wartchow E, Wintjes LT, Zohar Y, Fernández-Moreno MA, Baris HN, Donnini C, Minczuk M, Rodenburg RJ, Van Hove JLK.

    Pathogenic variants in glutamyl-tRNA Gln amidotransferase subunits cause a lethal mitochondrial cardiomyopathy disorder.

    NATURE COMMUNICATIONS . 9(1): 4065-4065. Number of citations: 10

    [doi:10.1038/s41467-018-06250-w]