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Cancer stem cells and fibroinflammatory microenvironment

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  • Walter K, Rodriguez-Aznar E, Ferreira MSV, Frappart PO, Dittrich T, Tiwary K, Meessen S, Lerma L, Daiss N, Schulte LA, Najafova Z, Arnold F, Usachov V, Azoitei N, Erkan M, Lechel A, Brümmendorf TH, Seufferlein T, Kleger A, Tabarés E, Günes C, Johnsen SA, Beier F, Sainz B Jr, Hermann PC.

    Telomerase and Pluripotency Factors Jointly Regulate Stemness in Pancreatic Cancer Stem Cells.

    Cancers . 13(13): .

    [doi:10.3390/cancers13133145]

  • Ai, Jiaoyu, Wormann, Sonja M, Gorgulu, Kivanc, Vallespinos, Mireia, Zagorac, Sladjana, Alcala, Sonia, Wu, Nan, Kabacaoglu, Derya, Berninger, Alexandra, Navarro, Diego, Kaya-Aksoy, Ezgi, Ruess, Dietrich A, Ciecielski, Katrin J, Kowalska, Marlena, Demir, Ekin I, Ceyhan, Guralp O, Heid, Irina, Braren, Rickmer, Riemann, Marc, Schreiner, Sabrina, Hofmann, Samuel, Kutschke, Maria, Jastroch, Martin, Slotta-Huspenina, Julia, Muckenhuber, Alexander, Schlitter, Anna Melissa, Schmid, Roland M, Steiger, Katja, Diakopoulos, Kalliope N, Lesina, Marina, Sainz, Bruno Jr, Algul, Hana.

    BCL3 couples cancer stem cell enrichment with pancreatic cancer molecular subtypes.

    Gastroenterology . : .

    [doi:10.1053/j.gastro.2021.03.051]

  • Earl, Julie, Barreto, Emma, Castillo, Maria E., Fuentes, Raquel, Rodriguez-Garrote, Mercedes, Ferreiro, Reyes, Reguera, Pablo, Munoz, Gloria, Garcia-Seisdedos, David, Lopez, Jorge Villalon, Sainz, Bruno, Malats, Nuria, Carrato, Alfredo.

    Somatic Mutation Profiling in the Liquid Biopsy and Clinical Analysis of Hereditary and Familial Pancreatic Cancer Cases Reveals KRAS Negativity and a Longer Overall Survival

    Cancers . 13(7): 1612.

    [doi:10.3390/cancers13071612]

  • Conde, Elisa, Earl, Julie, Crespo-Toro, Lorena, Blanco-Agudo, Carolina, Ramos-Munoz, Edurne, Rodriguez-Serrano, E. Macarena, Martinez avila, Jose Carlos, Salinas-Munoz, Laura, Serrano-Huertas, Silvia, Ferreiro, Reyes, Rodriguez-Garrote, Mercedes, Sainz B Jr, Massuti, Bartomeu, Alfonso, Pilar Garcia, Benavides, Manuel, Aranda, Enrique, Garcia-Bermejo, Maria Laura, Carrato, Alfredo.

    Biomarkers Associated with Regorafenib First-Line Treatment Benefits in Metastatic Colorectal Cancer Patients: REFRAME Molecular Study

    Cancers . 13(7): 1710.

    [doi:10.3390/cancers13071710]

  • Gout, Johann, Perkhofer, Lukas, Morawe, Mareen, Arnold, Frank, Ihle, Michaela, Biber, Stephanie, Lange, Sebastian, Roger, Elodie, Kraus, Johann M., Stifter, Katja, Hahn, Stephan A., Zamperone, Andrea, Engleitner, Thomas, Muller M, Walter, Karolin, Rodriguez-Aznar, Eva, Sainz B Jr, Hermann, Patrick C., Hessmann, Elisabeth, Muller S, Azoitei, Ninel, Lechel, Andre, Liebau, Stefan, Wagner, Martin, Simeone, Diane M., Kestler, Hans A., Seufferlein, Thomas, Wiesmuller L, Rad, Roland, Frappart, Pierre-Olivier, Kleger, Alexander.

    Synergistic targeting and resistance to PARP inhibition in DNA damage repair-deficient pancreatic cancer

    Gut . 70(4): 743-760. Number of citations: 5

    [doi:10.1136/gutjnl-2019-319970]

  • López-Gil JC, Martin-Hijano, Laura, Hermann, Patrick C., Sainz B Jr.

    The CXCL12 Crossroads in Cancer Stem Cells and Their Niche

    Cancers . 13(3): 469. Number of citations: 1

    [doi:10.3390/cancers13030469]

  • Courtois, Sarah, de Luxan-Delgado, Beatriz, Penin-Peyta, Laure, Royo-Garcia, Alba, Parejo-Alonso, Beatriz, Jagust, Petra, Alcala, Sonia, Rubiolo, Juan A., Sanchez, Laura, Sainz B Jr, Heeschen, Christopher, Sancho, Patricia.

    Inhibition of Mitochondrial Dynamics Preferentially Targets Pancreatic Cancer Cells with Enhanced Tumorigenic and Invasive Potential

    Cancers . 13(4): 698. Number of citations: 1

    [doi:10.3390/cancers13040698]

  • Delle Cave, Donatella, Rizzo, Riccardo, Sainz B Jr, Gigli, Giuseppe, del Mercato, Loretta L., Lonardo, Enza.

    The Revolutionary Roads to Study Cell-Cell Interactions in 3D In Vitro Pancreatic Cancer Models

    Cancers . 13(4): 930.

    [doi:10.3390/cancers13040930]

  • Alcala, Sonia, Mayoral-Varo, Victor, Ruiz-Canas, Laura, Lopez-Gil, Juan Carlos, Heeschen, Christopher, Martin-Perez, Jorge, Sainz B Jr.

    Targeting SRC Kinase Signaling in Pancreatic Cancer Stem Cells (vol 21, 7437, 2020)

    INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES . 21(23): 9215.

    [doi:10.3390/ijms21239215]

  • Valle, Sandra, Alcala, Sonia, Martin-Hijano, Laura, Cabezas-Sainz, Pablo, Navarro, Diego, Munoz ER, Yuste, Lourdes, Tiwary, Kanishka, Walter, Karolin, Ruiz-Canas, Laura, Alonso-Nocelo, Marta, Rubiolo, Juan A., Gonzalez-Arnay, Emilio, Heeschen, Christopher, Garcia-Bermejo, Laura, Hermann, Patrick C., Sanchez, Laura, Sancho, Patricia, Fernandez-Moreno MA, Sainz B Jr.

    Exploiting oxidative phosphorylation to promote the stem and immunoevasive properties of pancreatic cancer stem cells

    NATURE COMMUNICATIONS . 11(1): 5265-5265. Number of citations: 10

    [doi:10.1038/s41467-020-18954-z]

  • Alcala, Sonia, Mayoral-Varo, Victor, Ruiz-Canas, Laura, Lopez-Gil, Juan Carlos, Heeschen, Christopher, Martin-Perez, Jorge, Sainz B Jr.

    Targeting SRC Kinase Signaling in Pancreatic Cancer Stem Cells

    INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES . 21(20): 7437. Number of citations: 4

    [doi:10.3390/ijms21207437]

  • Cabezas-Sainz, Pablo, Pensado-Lopez, Alba, Sainz B Jr, Sanchez, Laura.

    Modeling Cancer Using Zebrafish Xenografts: Drawbacks for Mimicking the Human Microenvironment

    Cells . 9(9): 1978. Number of citations: 4

    [doi:10.3390/cells9091978]

  • Cash, Timothy P., Alcala, Sonia, Rico-Ferreira MDR, Hernandez-Encinas, Elena, Garcia, Jennifer, Albarrán MI, Valle, Sandra, Muñoz J, Martinez-Gonzalez, Sonia, Blanco-Aparicio, Carmen, Pastor, Joaquin, Serrano, Manuel, Sainz B.

    Induction of Lysosome Membrane Permeabilization as a Therapeutic Strategy to Target Pancreatic Cancer Stem Cells

    Cancers . 12(7): 1790. Number of citations: 2

    [doi:10.3390/cancers12071790]

  • Frappart, Pierre-Olivier, Walter, Karolin, Gout, Johann, Beutel, Alica K., Morawe, Mareen, Arnold, Frank, Breunig, Markus, Barth, Thomas F. E., Marienfeld, Ralf, Schulte, Lucas, Ettrich, Thomas, Hackert, Thilo, Svinarenko, Michael, Rösler R, Wiese, Sebastian, Wiese, Heike, Perkhofer, Lukas, Müller M, Lechel, Andre, Sainz B, Hermann, Patrick C., Seufferlein, Thomas, Kleger, Alexander.

    Pancreatic cancer-derived organoids - a disease modeling tool to predict drug response

    UNITED EUROPEAN GASTROENTEROLOGY JOURNAL . 8(5): 594-606. Number of citations: 18

    [doi:10.1177/2050640620905183]

  • Alcala, Sonia, Sancho, Patricia, Martinelli, Paola, Navarro, Diego, Pedrero, Coral, Martin-Hijano, Laura, Valle, Sandra, Earl, Julie, Rodriguez-Serrano, Macarena, Ruiz-Canas, Laura, Rojas, Katerin, Carrato, Alfredo, Garcia-Bermejo, Laura, Fernández-Moreno MÁ, Hermann, Patrick C., Sainz Jr, Bruno.

    ISG15 and ISGylation is required for pancreatic cancer stem cell mitophagy and metabolic plasticity

    NATURE COMMUNICATIONS . 11(1): 2682-2682. Number of citations: 9

    [doi:10.1038/s41467-020-16395-2]

  • Lerma, L., Muñoz AL, Garcia Utrilla, R., Sainz Jr, B., Lim, F., Tabares, E., Gomez-Sebastian, S..

    Partial complementation between the immediate early proteins ICP4 of herpes simplex virus type 1 and IE180 of pseudorabies virus

    VIRUS RESEARCH . 279: 197896-197896.

    [doi:10.1016/j.virusres.2020.197896]

  • Martin-Hijano, Laura, Sainz B.

    The Interactions Between Cancer Stem Cells and the Innate Interferon Signaling Pathway

    Frontiers in immunology . 11: 526-526. Number of citations: 7

    [doi:10.3389/fimmu.2020.00526]

  • Schulte, Lucas-Alexander, López-Gil JC, Sainz B, Hermann, Patrick C..

    The Cancer Stem Cell in Hepatocellular Carcinoma

    Cancers . 12(3): 684. Number of citations: 12

    [doi:10.3390/cancers12030684]