Neuroproteins-stroke

2022 Activity indicators

3 national public projects: ISCIII, MINECO.
1 private led projects.
18 clinical led trials.
4 competitive HR contracts.
35 publications
IF: 178.39
Publications in D1: 7 (20%).
Publications in Q1: 19 (54%).
1 supervised read thesis.
Public agency evaluators: 2 PIs.
Members of editorial committees: 1 PI.
1 patent granted (P201131338) protecting quinolinitrones at national level for the same purpose.
1 patent applied for to protect new quinolylnitrone compounds PCT/EP2019/077525 extended in US and EU
1 new patent for new steronitrone compounds with European priority application EP20382158 and PCT/EP2021/055653.
1 application for new hybrid compounds with Spanish patent application P202130259.

Milestones

Publication of a landmark clinical study: "Factor XIa inhibition with asundexian after acute non-cardioembolic ischaemic stroke (PACIFIC-Stroke): an international, randomised, double-blind, placebo-controlled, phase 2b trial. Shoamanesh A, Mundl H, Smith EE, Masjuan J, et al. Lancet 2022. 400:997-1007. doi: 10.1016/S0140-6736(22)01588-4. PMID: 36063821."
Publication of a potential drug for the treatment of ischemic stroke: "Preclinical Characterization of Antioxidant Quinolyl Nitrone QN23 as a New Candidate for the Treatment of Ischemic Stroke". Martínez-Alonso E, Escobar-Peso A, Aliena-Valero A, Torregrosa G, Chioua M, Fernández-Serra R, González-Nieto D, Ouahid Y, Salom JB, Masjuan J, Marco-Contelles J, Alcázar A. Antioxidants 2022. 11: 1186. doi:10.3390/antiox11061186".
Publication of a new mechanism of damage in cerebral ischemia: "Novel mechanism of hypoxic neuronal injury mediated by non-excitatory amino acids and astroglial swelling". Álvarez-Merz I, Fomitcheva IV, Sword J, Hernández-Guijo JM, Solís JM, Kirov S. A. Glia. 2022. 70:2108-2130. doi:10.1002/glia.24241. PMID: 35802030."
Publication on functional stimulation: "Combined Stimulation of the Substantia Nigra and the Subthalamic Nucleus for the Treatment of Refractory Gait Disturbances in Parkinson's Disease: A Preliminary Study". Villadóniga M, Cabañes-Martínez L, López-Viñas L, Fanjul S, Del Álamo M, & Regidor I. J Clin Med, 2022; 11, 2269. doi:10.3390/jcm11082269. PMID: 35456362."
Participation in multicenter studies related to stroke in patients with COVID. Highlighting among the 5 publications the works in Nature. "COVID-19 Host Genetic Initiative. A first update on the mapping of the human genetic architecture of COVID-19". Nature. 2022; 608(7921):E1-E10. doi: 10.1038/s41586-022-04826-7. Epub 2022 Aug 3. PMID: 35922517" and in J Stroke, Global "Impact of the COVID-19 Pandemic on Cerebral Venous Thrombosis and Mortality. J Stroke. 2022; 24(2):256-265. doi: 10.5853/jos.2022.00752. PMID: 35677980."

Bibliometrics

	Articles	Accum. FI	Mean IF	Articles Q1 or Q2	% in Q1 or Q2	Articles D1	% in D1
2018	20	46,38	2,90	8	40	1	5
2019	20	153,38	9,59	16	80	4	20
2020	22	68,50	3,61	11	50	4	18
2021	35	178,39	5,2	20	57	7	20
2022	25	426,049	18,524	19	76	6	24
	122	872,716	7,96	74	61	22	18