Neuroproteins-stroke

2024 Activity indicators

5 national public competitive projects: ISCIII, MINECO, CAM, MICINN
4 private projects led
11 clinical studies
2 HR competitive contracts
19 publications
IF: 104.50
Q1 publications: 16 (84%)
D1 publications: 7 (37 %)
Public agency evaluators: 3 PI
Members of editorial committees: 2 PI
6 active patent families::
- 1 patent family extended internationally in 11 countries protecting the use of steronitrones in neurodegenerative diseases (PCT/ ES2014/070421)
- 1 granted patent (P201131338) protecting quinolinitrones for the same purpose at national level
- 1 patent applied for to protect new quinolylnitrone compounds PCT/EP2019/077525, extended in the US and EU
- 1 new patent for new steronitrone compounds with European priority application EP20382158 and PCT/ EP2021/055653, extended in US and EU
- 1 application for a nitrone-like compound in stroke with European application EP22382680
- 1 application for a nitrone-like compound in deafness with European application EP22382706.4 and PCT/EP2023/07034

Milestones

Participation in a leading clinical study of hemorrhagic transformation in stroke: Chen CH, Shoamanesh A, Colorado P, Saad F, Lemmens R, De Marchis GM, Caso V, Xu L, Heenan L, Masjuan J, Christensen H, Connolly SJ, Khatri P, Mundl H, Hart RG, Smith EE. Hemorrhagic Transformation in Noncardioembolic Acute Ischemic Stroke: MRI Analysis From PACIFIC-STROKE. Stroke. 2024;55(6): 1477 - 1488. DOI:10.1161/STROKEAHA.123.045204.
Interesting publication of potential new drugs for the treatment of ischemic stroke: Escobar A, Martínez E, Hadjipavlou D, Alcázar A, Marco J. Synthesis, antioxidant and neuroprotective analysis of diversely functionalized a-aryl-N-alkyl nitrones as potential agents for ischemic stroke therapy. Eur J Med Chem. 2024;266: 116133 - 116133. DOI:10.1016/j.ejmech.2024.116133.
Suggestive publication of a new mechanism of toxicity in neuronal cells: Carretero VJ, Liccardi N, Tejedor MA, de Pascual R, Campano JH, Hernández JM. Lead exerts a depression of neurotransmitter release through a blockade of voltage dependent calcium channels in chromaffin cells. Toxicology. 2024;505: 153809 - 153809. DOI:10.1016/j.tox.2024.153809.
Original publication on a new functional monitoring: Cabañes L, Fedirchyk O, López L, Abreu F, Carrasco R, Del Álamo M, Regidor I. Usefulness of Intraoperative Neurophysiological Monitoring in Intradural Spinal Tumor Surgeries. J Clin Med. 2024;13(24). DOI:10.3390/jcm13247588.
First biomarkers identified in thrombi from stroke patients. These biomarkers will contribute to the improvement of stroke diagnosis and treatment. Doctoral thesis by Lorena Peracho (supervisors: J. Masjuan and A. Alcázar).

Bibliometrics

	Articles	Accum. FI	Mean IF	Articles Q1 or Q2	% in Q1 or Q2	Articles D1	% in D1
2020	22	68.50	3.61	11	50	4	18
2021	35	178.39	5.20	20	57	7	20
2022	25	426.05	18.52	19	76	6	24
2023	24	141.52	7.06	17	71	6	25
2024	19	104.50	5.50	19	100	7	37
	125	918.98	7.98	86	71	30	24