Neuroproteins-stroke
Group leader
Alberto Alcázar González
alberto.alcazar(ELIMINAR)@hrc.es
Principal Investigator
- Jaime Masjuán Vallejo
- Jesús Miguel Hernández Guijo
Collaborating Staff
- Alicia de Felipe Mimbrera
- Mercedes Gómez-Calcerrada Iniesta
- Emma Martínez Alonso
- Ignacio Regidor Bailly-Bailliere
- María Consuelo Matute Lozano
- Rocío Vera Lechuga
- Antonio Cruz Culebras
- Sebastián García Madrona
- Marcel Roca Sanz
- Marta del Álamo de Pedro
- Lidia Cabañes Martínez
- Cristina Moreno López
Principal Investigator
- Jaime Masjuán Vallejo
- Jesús Miguel Hernández Guijo
Collaborating Staff
- Alicia de Felipe Mimbrera
- Mercedes Gómez-Calcerrada Iniesta
- Emma Martínez Alonso
- Ignacio Regidor Bailly-Bailliere
- María Consuelo Matute Lozano
- Rocío Vera Lechuga
- Antonio Cruz Culebras
- Sebastián García Madrona
- Marcel Roca Sanz
- Marta del Álamo de Pedro
- Lidia Cabañes Martínez
- Cristina Moreno López
Strategic objectives
- To advance the understanding of ischemic stroke.
- To develop pharmacological strategies with therapeutic potential to improve functional recovery after ischemic stroke.
- Treatment of strokes in the acute phase.
- To develop neurophysiological techniques for the prevention of nervous system damage in high-risk situations.
Research lines
Lines of clinical research:
- Secondary prevention in stroke.
- Reperfusion therapies in cerebral infarction. Use of neuroprotective drugs.
- Unusual causes of stroke. Carotid artery web.
- Recurrent cardioembolic stroke. New indications for left atrial appendage closure. Carotid filters.
- Factor XI inhibitors in non-cardioembolic stroke.
- Analysis of thrombi removed by mechanical thrombectomy.
- Evaluation and programming of deep brain stimulation systems and their effect on balance and gait in patients.
- Impact of neurophysiological monitoring for neuroprotection.
Lines of experimental research:
- Mechanisms of cell death and neuroprotection in cerebral ischemia.
- Identification of biomarkers sensitive to resistance and vulnerability in cerebral ischemia.
- Development of new neuroprotective drugs for cerebral ischemia.
- Study of non-excitatory amino acid transporters as novel molecular targets in cerebral ischemia-induced damage.
Location
Ramón y Cajal University Hospital
Stroke Unit, Neurology Department, 5th Floor, Right Wing
Neuroproteins and Ischemia Laboratory, Basement Level, Right Wing
Autonomous University of Madrid
Department of Pharmacology
Faculty of Medicine
Keywords
Stroke, neuroprotection, cerebral ischemia, experimental models, therapeutic targets, reperfusion treatments, drug testing, molecular mechanisms, neuronal death