Lipid metabolism
The Clinical and Applied Lipidomics for Metabolism Research Group investigates the role of lipids, particularly ceramides and cholesterol, in cardiometabolic, liver, and neurodegenerative diseases. Its activities integrate basic, translational, and clinical research, with a strong focus on the identification of biomarkers and the development of advanced lipidomics and metabolomics methodologies using mass spectrometry.
The group is supported by competitive national funding, has a strong international scientific publication record, and is currently developing a patent. In addition, it contributes to the Lipidomic and Proteomic Characterization Unit (UCA-CLP) and maintains strategic collaborations at both the national and international levels.
Group leader
Diego Gómez-Coronado Cáceres
oscar.pastor(ELIMINAR)@salud.madrid.org
Tlf.: +34 91 336 8950
Collaborating Staff
- Rebeca Busto Durán
- Diego Gómez-Coronado Cáceres
- María del Carmen Santiuste Puente
- Gema de la Peña Martín
- Tamara Villanueva Blanco
- Álvaro Hidalgo Llorente
Group leader
Diego Gómez-Coronado Cáceres
oscar.pastor(ELIMINAR)@salud.madrid.org
Tlf.: +34 91 336 8950
Collaborating Staff
- Rebeca Busto Durán
- Diego Gómez-Coronado Cáceres
- María del Carmen Santiuste Puente
- Gema de la Peña Martín
- Tamara Villanueva Blanco
- Álvaro Hidalgo Llorente
Strategic objectives
- To investigate lipid metabolism, with a particular focus on ceramides, in disease pathophysiology, aiming to elucidate their biological role, characterize the underlying mechanisms, identify biomarkers for disease monitoring, and develop therapeutic strategies with translational potential.
- To consolidate a core mass spectrometry facility integrating multiple analytical platforms (LC-MS, GC-MS, HPTLC, and LC-qTOF), enabling the measurement of lipids and other metabolites in a wide range of biological samples, including plasma, serum, cerebrospinal fluid, cellular extracts, and tissues. The facility will provide robust bioinformatic analysis and efficient turnaround times, thereby supporting and enhancing participation in national and international preclinical research projects.
Research lines
- Investigation of ceramide metabolism, its biological function and therapeutic modulation, with the goal of preventing or reversing the progression of cardiometabolic diseases.
- Identification of biomarkers and development, standardization, and implementation of lipidomics and metabolomics methodologies based on mass spectrometry for translation into human health applications.
- Elucidation of the role of ceramides, cholesterol, and other lipid species in human nutrition and metabolic health
Location
Ramón y Cajal University Hospital
Biochemistry Laboratory-Research
Level -1, Right Side