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Translational Cancer Research

Our group has been focused for years on the identification, characterization and validation, through multidisciplinary approaches, of prognostic/predictive markers and potential therapeutic targets in tumors, in particular breast, gynecological carcinomas and sarcomas. An additional group goal is to gain insights into the molecular basis of chemo/radioresistance in cancer and to advance in the design of new, more effective and less toxic antitumor (nano)-therapies. Among our studies, we highlight those focused on analyzing the functional role in cancer of the chromosomal instability, cell cycle, mechanisms of cell death, intratumoral heterogeneity and the immune response to tumors.

Search for publications

Only original articles, editorials, guidelines.

  • Zak K, Bobinski M, Moreno-Bueno G, Romano A, Salumets A, Kurzepa J.

    Bisphenol exposure and gynecological health: A narrative review of current evidence and knowledge gaps.

    Chemosphere . 410: 145027-145027.

    [doi:10.1016/j.chemosphere.2026.145027]

  • Zarzuela L, López-Cepero IG, Rattigan KM, Reina-Bando A, Martín-Montalvo J, Sierra-Párraga JM, Sánchez-Escabias E, Morillo-Huesca M, Oltra SS, Ceballos-Chávez M, Capilla-González V, Moreno-Bueno G, Murdoch PDS, Reyes JC, Helgason GV, Tomé M, Durán RV.

    FGFR1 drives metabolic adaptation associated with temozolomide resistance in glioblastoma.

    CANCER LETTERS . 652: 218565-218565.

    [doi:10.1016/j.canlet.2026.218565]

  • Sánchez Gómez R, Pérez-Míes B, Palacios J, Moreno Bueno G, Calvo I, Solorzano JL, Neria F, Fernandez-Abad M, González-Martínez S, García-Estevez L.

    Association of Body Mass Index with Tumor-Infiltrating Lymphocytes and Treatment Response in Early HER2-Positive Breast Cancer.

    International Journal of Womens Health . 18: 596039-596039.

    [doi:10.2147/IJWH.S596039]

  • Jiménez-Castaño R, Narwade N, Moreno-Bueno G, Sánchez-Laorden B, Galcerán J, Youssef KK, Nieto MA.

    A hormetic transcriptional program coregulates invasion, proliferation and dormancy to define metastatic potential.

    Nature Communications . 17(1): .

    [doi:10.1038/s41467-026-70242-4]

  • Jiménez-Suárez J, Cimas FJ, Paricio JJ, Belandia B, Berrouayel Y, Arconada-Luque E, Matilla-Almazán S, Soffientini C, Percio S, Redondo-García S, García-Flores N, Garnés-García C, Fernández-Aroca P, Martínez-Gómez JJ, Fernández-Aramburo A, Nam-Cha SH, Rovida E, Pandiella A, Esparís-Ogando A, Pasquali S, Rodríguez-Manzaneque JC, Del Peso L, Ruiz-Hidalgo MJ, Sánchez-Prieto R.

    VCAN Is Essential for ERK5-Driven Tumorigenesis in Soft Tissue Sarcoma.

    International Journal of Biological Sciences . 22(5): 2452-2468.

    [doi:10.7150/ijbs.121402]

  • Silva-Llanes I, Smith LA, Abdelkader-Guillén A, Jiménez-Villegas J, Sarrió D, Moreno-Bueno G, Lastres-Becker I.

    GASDERMIN D-mediated pyroptosis as a therapeutic target in TAU-dependent frontotemporal dementia mouse model.

    JOURNAL OF BIOMEDICAL SCIENCE . 33(1): 6-6. Number of citations: 6

    [doi:10.1186/s12929-025-01210-1]

  • Jiménez-Suárez J, Garnés-García C, Fernández-Aroca P, Aparicio-Canada J, Belandia B, Ruiz-Hidalgo MJ, Sánchez-Prieto R, Cimas FJ.

    Specific transcriptional signature dataset of extracellular signal-regulated kinase 5 in leiomyosarcoma derived cell lines

    BMC Research Notes . 18(1): 477-477.

    [doi:10.1186/s13104-025-07551-2]

  • García-Estévez L, González-Rodríguez M, Calvo I, Orta A, Gión M, Moreno-Bueno G, Pérez-García JM, Cortés J.

    Obesity, overweight and breast cancer: new clinical data and implications for practice.

    Frontiers in Oncology . 15: 1579876-1579876. Number of citations: 9

    [doi:10.3389/fonc.2025.1579876]

  • Rodriguez-Baena FJ, Marquez-Galera A, Ballesteros-Martinez P, Castillo A, Diaz E, Moreno-Bueno G, Lopez-Atalaya JP, Sanchez-Laorden B.

    Microglial reprogramming enhances antitumor immunity and immunotherapy response in melanoma brain metastases

    CANCER CELL . 43(3): . Number of citations: 44

    [doi:10.1016/j.ccell.2025.01.008]

  • Monfort-Vengut A, Sanz-Gómez N, Ballesteros-Sánchez S, Ortigosa B, Cambón A, Ramos M, Lorenzo ÁM, Escribano-Cebrián M, Rosa-Rosa JM, Martínez-López J, Sánchez-Prieto R, Sotillo R, de Cárcer G.

    Osmotic stress influences microtubule drug response via WNK1 kinase signaling

    DRUG RESISTANCE UPDATES . 79: 101203-101203. Number of citations: 2

    [doi:10.1016/j.drup.2025.101203]

  • Morillo-Huesca M, G López-Cepero I, Conesa-Bakkali R, Tomé M, Watts C, Huertas P, Moreno-Bueno G, Durán RV, Martínez-Fábregas J.

    Radiotherapy resistance driven by Asparagine endopeptidase through ATR pathway modulation in breast cancer

    JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH . 44(1): 74-74. Number of citations: 5

    [doi:10.1186/s13046-025-03334-6]

  • Casas-Arozamena C, Lande KT, Diaz E, Vilar A, Cueva J, Arias E, Sampayo V, Abalo A, González N, Colás E, Gil-Moreno A, Abal M, Moreno-Bueno G, Sørlie T, Lindemann K, Muinelo-Romay L.

    Longitudinal circulating tumor DNA profiling in patients with advanced endometrial cancer using an off-the-shelf targeted NGS panel.

    Molecular Oncology . : .

    [doi:10.1002/1878-0261.70246]

  • Buffa M, Leiva D, Garcia-Jareño A, Garcés-Flores M, Díaz E, Lucantoni F, Telechea M, Chen L, Lucendo E, Shalaby R, Lolicato F, Kulig W, Garcia-Saez AJ, Moreno-Bueno G, Sancho M, Orzáez M.

    Disruption of MCL1/BOK transmembrane interaction as a novel strategy to induce cell death in tumours.

    Cell Death & Disease . : .

    [doi:10.1038/s41419-026-09074-5]