Biological chemistry

Group leader

Manuel Ángel Fernández Rodríguez

mangel.fernandezr(ELIMINAR)@uah.es

Principal Investigator

  • David Sucunza Sáenz
  • Estibaliz Merino Marcos
  • Javier Carreras Pérez-Aradros
  • Patricia García García
  • José Luis Aceña Bonilla

Collaborating Staff

  • Alberto Domingo Galán
  • Javier García Marín
  • Marta Durán Martínez
  • Jaime Mateos Gil
  • Rafael Martín Romero Segura
  • Mercedes Zurro de la Fuente
  • Jose Antonio Garcia Garcia
  • Ángela Martín-Serrano Ortiz
Imagen equipo

Group leader

Manuel Ángel Fernández Rodríguez

mangel.fernandezr(ELIMINAR)@uah.es

Principal Investigator

  • David Sucunza Sáenz
  • Estibaliz Merino Marcos
  • Javier Carreras Pérez-Aradros
  • Patricia García García
  • José Luis Aceña Bonilla

Collaborating Staff

  • Alberto Domingo Galán
  • Javier García Marín
  • Marta Durán Martínez
  • Jaime Mateos Gil
  • Rafael Martín Romero Segura
  • Mercedes Zurro de la Fuente
  • Jose Antonio Garcia Garcia
  • Ángela Martín-Serrano Ortiz

Strategic objectives

The group's research activity is focused on the design, synthesis and evaluation of small molecules of biological interest or pharmacological activity. To this end, we collaborate with groups with expertise in validated and emerging targets in different therapeutic areas.  The active research lines are focused on the development of new inhibitors on several targets involved in renal disease, on the search for reagents for cell staining and bioimaging and on the development of synthetic methodology applicable to carbo- and heterocycles of biological interest.

Research lines

  • Medicinal chemistry strategies in kidney disease.
    • Development of new inhibitors on targets involved in kidney disease (calpains, PTP1B and NIK).
    • Vehiculation of PNAs and drugs to the renal environment.
    • Search for alternatives to the use of glucose in peritoneal dialysis solutions.
  • Design and study of new chromophores for multiphoton absorption with potential application in cell staining and bioimaging.
  • Development of synthetic methodology for carbo- and heterocycles of biological interest. Organocatalysis. Photocatalysis.
  • Synthesis, reactivity and applications of BN-arenes.

Location

Dpt. Organic and Inorganic Chemistry


Pharmacy Faculty
Alcala University

+34 91 885 4761

Link to UAH group

Keywords

cellular staining and bioimaging, chronic kidney disease, bioactive azaheterocycles and azaborinos, metal catalysis, PET reagents, peptides and PNAs