Biological chemistry

Group leader

Juan José Vaquero López

juanjose.vaquero(ELIMINAR)@uah.es

Collaborators

  • Ramón Alajarín Ferrández
  • Ana María Cuadro Palacios
  • Alberto Domingo Galán
  • David Sucunza Sáenz
  • Manuel Ángel Fernández Rodríguez
  • Patricia García García
  • José Luis Aceña Bonilla
  • Javier García Marín
  • Ana Milián López
  • Ester Sans Panadés
  • Isabel Valencia Nieto
  • Jaime Tostado Sánchez
  • Javier Carreras Pérez-Aradros
  • Álvaro González Molina
  • Francisco Maqueda Zelaya
Imagen equipo

Group leader

Juan José Vaquero López

juanjose.vaquero(ELIMINAR)@uah.es

Collaborators

  • Ramón Alajarín Ferrández
  • Ana María Cuadro Palacios
  • Alberto Domingo Galán
  • David Sucunza Sáenz
  • Manuel Ángel Fernández Rodríguez
  • Patricia García García
  • José Luis Aceña Bonilla
  • Javier García Marín
  • Ana Milián López
  • Ester Sans Panadés
  • Isabel Valencia Nieto
  • Jaime Tostado Sánchez
  • Javier Carreras Pérez-Aradros
  • Álvaro González Molina
  • Francisco Maqueda Zelaya

Strategic objectives

The group's research activity is aimed at the design, synthesis and evaluation of small molecules of biological interest or pharmacological activity. For this aim, we collaborate with groups that are experts in validated and emerging targets in different therapeutic areas. The active lines of research focus on the development of new inhibitors of several targets, the search for reagents for cell staining and bioimaging and the development of synthetic methodology applicable to carbo- and heterocycles of biological interest and PET reagents.

Research lines

  • Development of new inhibitors of targets involved in kidney disease (calpains, PTP1B and NIK).
  • Identification of alternatives to glucose for use in solutions for peritoneal dialysis.
  • Design and study of new chromophores similar to green fluorescent protein (GFP) and for multiphoton absorption with potential application in cell staining and bioimaging.
  • Development of synthetic methodology for carbo- and heterocycles of biological interest:
    • Gold-catalyzed electrophilic cycloisomerization processes.
    • Molecular diversity and natural alkaloids from the reagent, TosMIC.
    • Synthesis of azaborines.
    • PET reagents.

Location

Dpt. Organic and Inorganic Chemistry


Pharmacy Faculty
Alcala University
0034 91 885 4761

Link to UAH group

Keywords

cell staining and bioimaging; chronic renal disease; bioactive azaheterocycles and azaborines; metal catalysis; PET reagents; peptides.