Cancer stem cells and fibroinflammatory microenvironment

Group leader

Bruno Sainz Anding

bruno.sainz(ELIMINAR)@uam.es

Tlf.: + 34 91 497 54 20

Collaborators

  • Sonia Alcalá Sánchez
  • Laura Martín Hijano
  • Sandra Valle Rodríguez
  • Patricia Sánchez Tomero
  • Alfonso Cordero Barreal
  • Diego Navarro Vera
  • Laura Ruiz Cañas
  • María Isabel Sánchez Pérez
  • Adrian Palencia Campos
Imagen equipo

Group leader

Bruno Sainz Anding

bruno.sainz(ELIMINAR)@uam.es

Tlf.: + 34 91 497 54 20

Collaborators

  • Sonia Alcalá Sánchez
  • Laura Martín Hijano
  • Sandra Valle Rodríguez
  • Patricia Sánchez Tomero
  • Alfonso Cordero Barreal
  • Diego Navarro Vera
  • Laura Ruiz Cañas
  • María Isabel Sánchez Pérez
  • Adrian Palencia Campos

Strategic objectives

  • Actively participate in national and international networks and projects in the cancer field, with a focus on the biology of cancer stem cells and the tumour microenvironment.
  • Develop new technologies and systems for personalised medicine focused on the identification of drugs that eliminate cancer stem cells.
  • Reinforce alliances and collaborations between the business, academic and public health sectors.
  • Drive scientific and technological excellence at European level by constituting a fundamental frame of reference in cancer-based studies.

Research lines

  • Identification and characterisation of new biomarkers for the detection of CSCs in different solid tumours.
  • Identification of key proteins to develop and/or maintain the phenotype of CSCs, which includes characteristics such as pluripotency, epithelium-mesenchymal transition (EMT), oxidative phosphorylation  or chemoresistance.
  • Characterisation of the cell niche and the tumour microenvironment that surrounds the CSCs and the communication between both.
  • Development of the liquid biopsy for the isolation of blood cancer stem cells for their characterisation and validation as an early cancer detection marker.
  • Development of a platform to evaluate the chemosensitivity of cancer stem cells to drugs for application in personalised medicine.

Location

 Faculty of Medicine


 Laboratory B33/B35
 Madrid Autonomous University
 +34 91 497 54 20

 Link to UAM group

Keywords

cancer stem cells, tumour microenvironment, tumour associated macrophages, ductal pancreatic adenocarcinoma, chemoresistance, mitochondrial respiration, oncolytic viruses