Visual Neurophisiology
Group leader
Pedro de la Villa Polo
Tlf.: +34 91 885 45 23
Principal Investigator
- Roman Blanco Velasco
- Alicia Mansilla Aparicio
Collaborating Staff
- Francisco Germain Martinez
- Consuelo Pérez Rico
- Cristina Alcácer Fernández-Coronado
- Mateo Pazo González
- Lorena Aguado García
- María José Casarejos Fernández
- Cecilia Fernández Vaquero
Principal Investigator
- Roman Blanco Velasco
- Alicia Mansilla Aparicio
Collaborating Staff
- Francisco Germain Martinez
- Consuelo Pérez Rico
- Cristina Alcácer Fernández-Coronado
- Mateo Pazo González
- Lorena Aguado García
- María José Casarejos Fernández
- Cecilia Fernández Vaquero
Strategic objectives
- Development of a therapeutic strategy based on optopharmacology.
- Evaluation of the therapeutic effect of pharmacological, neuroprotective, and neuromodulatory agents incorporated into PLGA particles.
- Development of neuroprotective agents for retinal neurodegeneration.
Research lines
- Evaluation of the presence of light responses in blind mice injected with photoswitches, using electrophysiological recording techniques and visual behavior evaluation techniques.
- Preparation and characterization of PLGA particles loaded with therapeutic agents for their application in models of retinal cell degeneration, with molecular release study, injection of PLGA particles and functional effectiveness studies.
- Experimental models of glaucoma and mechanisms of neuroprotection of retinal ganglion cells.
- Protective role of physical exercise in neurodegenerative diseases.
- Development of synaptic modulators for the treatment of neurodegenerative and neurodevelopmental diseases.
Location
University of Alcalá
Visual Neurophysiology Lab
Department of Systems Biology
Faculty of Medicine
Keywords
Retina, synapse, calcium sensors, electroretinography, multifocal electroretinography (mfERG), retinitis pigmentosa, experimental models, multifocal visual evoked potentials (mfVEP)