Reprogramming of Eukaryotic and Prokaryotic Microbial Systems and Processes

Imagen equipo

Group leader

César Nombela Cano

cnombela(ELIMINAR)@uimp.es; cnombela@ucm.es

Tlf.: +34 91 394 17 44

Principal Investigators

  • Javier Arroyo Nombela
  • Concepción Gil García
  • María Molina Martín
  • Jesús Pla Alonso

Collaborators

  • Rebeca Alonso Monge
  • Antonio Daniel Prieto Prieto
  • Sonia Díez Muñiz
  • Teresa Fernández-Acero Bascones
  • Raúl García Sánchez
  • Víctor Jiménez Cid
  • Humberto Martín Brieva
  • Victoria Mascaraque Martin
  • Gloria Molero Marín-Portugués
  • Lucía Monteoliva Díaz
  • Aida Pitarch Velasco
  • Mª Isabel Rodríguez Escudero
  • José Manuel Rodríguez Peña
  • Elvira Román González
  • Ana Belén Sanz Santamaría
  • Gema González Rubio
  • Elena Jiménez Gutiérrez
  • Julia María Coronas Serna
  • Angela Sellers Moya
  • Susana Hidalgo Vico
  • Carmen García Durán
  • Lucía Sastre Vergara
  • Noelia Blázquez Díaz
  • Raquel Martínez López
  • Elba del Val Oriza
  • Marta Valentí Sanguino
  • Ana Borrajo López
Imagen equipo

Group leader

César Nombela Cano

cnombela(ELIMINAR)@uimp.es; cnombela@ucm.es

Tlf.: +34 91 394 17 44

Principal Investigators

  • Javier Arroyo Nombela
  • Concepción Gil García
  • María Molina Martín
  • Jesús Pla Alonso

Collaborators

  • Rebeca Alonso Monge
  • Antonio Daniel Prieto Prieto
  • Sonia Díez Muñiz
  • Teresa Fernández-Acero Bascones
  • Raúl García Sánchez
  • Víctor Jiménez Cid
  • Humberto Martín Brieva
  • Victoria Mascaraque Martin
  • Gloria Molero Marín-Portugués
  • Lucía Monteoliva Díaz
  • Aida Pitarch Velasco
  • Mª Isabel Rodríguez Escudero
  • José Manuel Rodríguez Peña
  • Elvira Román González
  • Ana Belén Sanz Santamaría
  • Gema González Rubio
  • Elena Jiménez Gutiérrez
  • Julia María Coronas Serna
  • Angela Sellers Moya
  • Susana Hidalgo Vico
  • Carmen García Durán
  • Lucía Sastre Vergara
  • Noelia Blázquez Díaz
  • Raquel Martínez López
  • Elba del Val Oriza
  • Marta Valentí Sanguino
  • Ana Borrajo López

STRATEGIC OBJECTIVES

  • Identification of effector proteins of the cell integrity route of the yeast Saccharomyces cerevisiae, as potential therapeutic targets for drugs that block the mechanisms of adaptation in situations of stress that compromise cell integrity.
  • Reconfiguration of the cell integrity route through the spatial redistribution of its components or of human heterological proteins that activate this route. Interference in cell signalling caused by bacterial virulence effectors.
  • Study of the involvement of the signal transduction routes in the pathogenesis and  modulation of the immune response of the host, as well as the genetic mechanisms that regulate the adaptation to the commensal state for the development of fungal probiotics.
  • Proteomic study on the microorganism-host interaction using the Candida albicans and human macrophages model and development of methods for diagnosis and prognosis of infectious diseases using protein microarrays, antibody microarrays and directed proteomic methods (SRM).

RESEARCH LINES

  • The cell integrity route in yeasts as a fundamental survival circuit: molecular mechanisms of activation, development and regulation of adaptation responses.
  • Signal transduction in Saccharomyces cerevisiae. Reprogramming of the cell integrity route through synthetic biology and bacterial virulence protein expression and human oncogenic protein expression.
  • Pathogenicity mechanisms adaptation to the commensal state of Candida albicans: the role of the microbiota and the immune response of the host.
  • Proteomic of microorganism-host interaction, gut microbiota and related human proteins.

Location

Department of Microbiology II
Pharmacy Faculty.
Madrid Complutense University
Plaza Ramón y Cajal s/n
+34 91 394 1744

Link to UCM group

Keywords

Yeasts, Saccharomyces, Candida, signal transduction, antifungals, fungal infections, commensalism, microbiota, bacterial virulence, oncogenic routes, proteomics, transcriptomics, functional genomics